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    Stx6 syntaxin 6 [ Mus musculus (house mouse) ]

    Gene ID: 58244, updated on 2-Nov-2024

    Summary

    Official Symbol
    Stx6provided by MGI
    Official Full Name
    syntaxin 6provided by MGI
    Primary source
    MGI:MGI:1926235
    See related
    Ensembl:ENSMUSG00000026470 AllianceGenome:MGI:1926235
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310039E05Rik; 2410005I16Rik
    Summary
    Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in regulation of protein localization. Acts upstream of or within endosome organization. Located in phagocytic vesicle and trans-Golgi network membrane. Orthologous to human STX6 (syntaxin 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 26.2), whole brain E14.5 (RPKM 15.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Stx6 in Genome Data Viewer
    Location:
    1 G3; 1 66.46 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (155034374..155083405)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (155158628..155207567)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41981 Neighboring gene predicted gene, 30922 Neighboring gene STARR-positive B cell enhancer ABC_E2569 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:157001032-157001362 Neighboring gene STARR-positive B cell enhancer ABC_E500 Neighboring gene major histocompatibility complex, class I-related Neighboring gene high mobility group protein B3 pseudogene Neighboring gene cDNA sequence BC034090 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:157081058-157081259 Neighboring gene predicted gene, 31102 Neighboring gene STARR-positive B cell enhancer ABC_E7760 Neighboring gene xenotropic and polytropic retrovirus receptor 1 Neighboring gene predicted gene, 17974

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables syntaxin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi vesicle transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytic recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within endosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde transport, endosome to Golgi ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in synaptic vesicle to endosome fusion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic vesicle to endosome fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle fusion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SNARE complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagocytic vesicle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in recycling endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021433.3NP_067408.1  syntaxin-6

      See identical proteins and their annotated locations for NP_067408.1

      Status: VALIDATED

      Source sequence(s)
      BM899312, BQ749205, BU613686, CF737112, CJ088919, CN456515, CX220575
      Consensus CDS
      CCDS35741.1
      UniProtKB/Swiss-Prot
      Q9D3A1, Q9D729, Q9JKK1
      UniProtKB/TrEMBL
      Q3UA21
      Related
      ENSMUSP00000027743.8, ENSMUST00000027743.13
      Conserved Domains (2) summary
      cd15851
      Location:166231
      SNARE_Syntaxin6; SNARE motif of syntaxin 6
      pfam09177
      Location:13103
      Syntaxin-6_N; Syntaxin 6, N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      155034374..155083405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529766.5XP_006529829.1  syntaxin-6 isoform X1

      UniProtKB/TrEMBL
      Q3UA21
      Related
      ENSMUSP00000141976.2, ENSMUST00000193059.6
      Conserved Domains (2) summary
      cd15851
      Location:166231
      SNARE_Syntaxin6; SNARE motif of syntaxin 6
      pfam09177
      Location:13103
      Syntaxin-6_N; Syntaxin 6, N-terminal
    2. XM_036152546.1XP_036008439.1  syntaxin-6 isoform X3

      Conserved Domains (1) summary
      cd15851
      Location:65130
      SNARE_Syntaxin6; SNARE motif of syntaxin 6
    3. XM_017321868.3XP_017177357.1  syntaxin-6 isoform X2

      Conserved Domains (1) summary
      cd15851
      Location:65130
      SNARE_Syntaxin6; SNARE motif of syntaxin 6