U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    VLDLR very low density lipoprotein receptor [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574284, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    VLDLRprovided by VGNC
    Official Full Name
    very low density lipoprotein receptorprovided by VGNC
    Primary source
    VGNC:VGNC:78774
    See related
    Ensembl:ENSMMUG00000015093
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See VLDLR in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 15 NC_041768.1 (81221283..81255845, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 15 NC_027907.1 (81867938..81904681, complement)

    Chromosome 15 - NC_041768.1Genomic Context describing neighboring genes Neighboring gene pumilio RNA binding family member 3 Neighboring gene uncharacterized LOC114672804 Neighboring gene potassium voltage-gated channel modifier subfamily V member 2 Neighboring gene uncharacterized LOC106993776 Neighboring gene bcl-2-like protein 12 pseudogene Neighboring gene uncharacterized LOC114672805 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Low-density lipoprotein receptor gene therapy using helper-dependent adenovirus produces long-term protection against atherosclerosis in a mouse model of familial hypercholesterolemia. Nomura S, et al. Gene Ther, 2004 Oct. PMID 15269711
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables apolipoprotein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    very low-density lipoprotein receptor

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032907.1 → NP_001028079.1  very low-density lipoprotein receptor precursor

      See identical proteins and their annotated locations for NP_001028079.1

      Status: VALIDATED

      Source sequence(s)
      AY466855
      UniProtKB/TrEMBL
      H9ERP6, Q6S4M1
      Related
      ENSMMUP00000019793.3, ENSMMUT00000021167.4
      Conserved Domains (8) summary
      smart00192
      Location:71 → 103
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:505 → 547
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:396 → 426
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:33 → 67
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam01456
      Location:751 → 813
      Mucin; Mucin-like glycoprotein
      pfam00057
      Location:237 → 273
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:568 → 608
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:360 → 394
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041768.1 Reference Mmul_10 Primary Assembly

      Range
      81221283..81255845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028834203.1 → XP_028690036.1  very low-density lipoprotein receptor isoform X3

      UniProtKB/TrEMBL
      F6WUJ6
      Related
      ENSMMUP00000019791.4, ENSMMUT00000021165.4
      Conserved Domains (7) summary
      smart00192
      Location:145 → 177
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:538 → 580
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:429 → 459
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:107 → 141
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:270 → 306
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:601 → 641
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:393 → 427
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. XM_015117783.2 → XP_014973269.1  very low-density lipoprotein receptor isoform X2

      UniProtKB/TrEMBL
      F6WNN2
      Conserved Domains (8) summary
      smart00192
      Location:145 → 177
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:538 → 580
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:429 → 459
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:107 → 141
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam01456
      Location:784 → 846
      Mucin; Mucin-like glycoprotein
      pfam00057
      Location:270 → 306
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:601 → 641
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:393 → 427
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    3. XM_015117782.2 → XP_014973268.1  very low-density lipoprotein receptor isoform X1

      UniProtKB/TrEMBL
      F6WNM1, F6WNN2
      Related
      ENSMMUP00000019794.4, ENSMMUT00000021168.4
      Conserved Domains (7) summary
      smart00192
      Location:145 → 177
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:579 → 621
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:470 → 500
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:107 → 141
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:311 → 347
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:642 → 682
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:434 → 468
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.