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    SLC6A3 solute carrier family 6 member 3 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574143, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SLC6A3provided by VGNC
    Official Full Name
    solute carrier family 6 member 3provided by VGNC
    Primary source
    VGNC:VGNC:77619
    Locus tag
    EGK_06774
    See related
    Ensembl:ENSMMUG00000005198
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    DAT
    Orthologs
    human mouse all
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    Genomic context

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    See SLC6A3 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 6 NC_041759.1 (1339149..1388879, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 6 NC_027898.1 (1285277..1335123, complement)

    Chromosome 6 - NC_041759.1Genomic Context describing neighboring genes Neighboring gene CLPTM1 like Neighboring gene uncharacterized LOC100424869 Neighboring gene lysophosphatidylcholine acyltransferase 1 Neighboring gene uncharacterized LOC114678732

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dopamine transporter gene susceptibility to methylation is associated with impulsivity in nonhuman primates. Rajala AZ, et al. J Neurophysiol, 2014 Nov 1. PMID 25122707, Free PMC Article
    2. Age-related changes in dopamine transporters and accumulation of 3-nitrotyrosine in rhesus monkey midbrain dopamine neurons: relevance in selective neuronal vulnerability to degeneration. Kanaan NM, et al. Eur J Neurosci, 2008 Jun. PMID 18598263, Free PMC Article
    3. Effects of in utero cocaine exposure on the expression of mRNAS encoding the dopamine transporter and the D1, D2 and D5 dopamine receptor subtypes in fetal rhesus monkey. Choi WS, et al. Brain Res Dev Brain Res, 1996 Oct 23. PMID 8922687
    4. Molecular cloning and expression of the rhesus macaque D1 dopamine receptor gene. Machida CA, et al. Mol Pharmacol, 1992 Apr. PMID 1533268
    5. Sequence variation in the primate dopamine transporter gene and its relationship to social dominance. Miller-Butterworth CM, et al. Mol Biol Evol, 2008 Jan. PMID 17934207

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNA of the impulsive but not the calm subjects was methylated at one DAT SNP.
      Title: Dopamine transporter gene susceptibility to methylation is associated with impulsivity in nonhuman primates.
    2. nitrative damage accumulates in midbrain neurons with age; The capacity of a dopamine neuron to accumulate more cytosolic DA, as inferred from DA transporter expression, is related to accumulation of nitrative damage
      Title: Age-related changes in dopamine transporters and accumulation of 3-nitrotyrosine in rhesus monkey midbrain dopamine neurons: relevance in selective neuronal vulnerability to degeneration.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables dopamine:sodium symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables norepinephrine:sodium symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dopamine uptake involved in synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in norepinephrine transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuronal cell body membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sodium-dependent dopamine transporter
    Names
    solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032826.1 → NP_001027998.1  sodium-dependent dopamine transporter

      See identical proteins and their annotated locations for NP_001027998.1

      Status: PROVISIONAL

      Source sequence(s)
      AF286446
      UniProtKB/TrEMBL
      A0A5F7ZKX1, Q7JHP8
      Conserved Domains (1) summary
      cd11514
      Location:60 → 614
      SLC6sbd_DAT1; Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041759.1 Reference Mmul_10 Primary Assembly

      Range
      1339149..1388879 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015139698.2 → XP_014995184.1  sodium-dependent dopamine transporter isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZKX1, A0A8J8XR80, F7CT33, G7NBG6, Q7JHP9
      Related
      ENSMMUP00000006879.4, ENSMMUT00000007320.4
      Conserved Domains (1) summary
      cd11514
      Location:60 → 614
      SLC6sbd_DAT1; Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Research Materials