U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    SPINK1 serine peptidase inhibitor Kazal type 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 574092, updated on 4-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SPINK1provided by VGNC
    Official Full Name
    serine peptidase inhibitor Kazal type 1provided by VGNC
    Primary source
    VGNC:VGNC:35219
    See related
    BGD:BT12464; Ensembl:ENSBTAG00000015558
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SPINK1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (59050312..59057310, complement)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene janus kinase and microtubule interacting protein 2 Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene secretoglobin family 3A member 2 Neighboring gene chromosome 7 C5orf46 homolog

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The structure of the bovine pancreatic scretory trypsin inhibitor--Kazal's inhibitor. II. The order of the tryptic peptides. Greene LJ, et al. J Biol Chem, 1969 May 25. PMID 5769997
    2. The structure of the bovine pancreatic secretory trypsin inhibitor--Kazal's inhibitor. 3. Determination of the disulfide bonds and proteolysis by thermolysin. Guy O, et al. J Biol Chem, 1971 Dec 25. PMID 5135319
    3. Partially folded bovine pancreatic trypsin inhibitor analogues attain fully native structures when co-crystallized with S195A rat trypsin. Getun IV, et al. J Mol Biol, 2008 Jan 18. PMID 18054043
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Partially folded bovine pancreatic trypsin inhibitor analogues attain fully native structures when co-crystallized with S195A rat trypsin.
      Title: Partially folded bovine pancreatic trypsin inhibitor analogues attain fully native structures when co-crystallized with S195A rat trypsin.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    serine protease inhibitor Kazal-type 1
    Names
    pancreatic secretory trypsin inhibitor
    serine protease inhibitor, Kazal type 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025348.1 → NP_001020519.1  serine protease inhibitor Kazal-type 1 precursor

      See identical proteins and their annotated locations for NP_001020519.1

      Status: PROVISIONAL

      Source sequence(s)
      AY911325
      UniProtKB/Swiss-Prot
      P00996, Q56K02
      UniProtKB/TrEMBL
      A0AAA9T1G5
      Related
      ENSBTAP00000020673.4, ENSBTAT00000020673.6
      Conserved Domains (2) summary
      cd01327
      Location:35 → 79
      KAZAL_PSTI; Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the ...
      cl28910
      Location:1 → 58
      MFS; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      59050312..59057310 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00996.2 GenPept UniProtKB/Swiss-Prot:P00996

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials