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    Cnr2 cannabinoid receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 57302, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Cnr2provided by RGD
    Official Full Name
    cannabinoid receptor 2provided by RGD
    Primary source
    RGD:619713
    See related
    EnsemblRapid:ENSRNOG00000009260 AllianceGenome:RGD:619713
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CB2; CB-2; CB2C; rCB2; CNR2C
    Summary
    Enables cannabinoid receptor activity. Involved in several processes, including negative regulation of GABAergic synaptic transmission; negative regulation of mast cell activation; and negative regulation of nitric-oxide synthase activity. Located in dendrite and neuronal cell body. Is extrinsic component of cytoplasmic side of plasma membrane. Used to study Huntington's disease; arthritis; and sciatic neuropathy. Biomarker of pancreatitis. Orthologous to human CNR2 (cannabinoid receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 203.0), Lung (RPKM 25.2) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cnr2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (153408968..153435092)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (148125222..148151548)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (154242010..154268126)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene serine and arginine rich splicing factor 10 Neighboring gene proline-rich nuclear receptor coactivator 2 Neighboring gene alpha-L-fucosidase 1 Neighboring gene 3-hydroxy-3-methylglutaryl-CoA lyase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. [Activation of cannabinoid receptor 2 alleviates acute lung injury in rats with lipopolysaccharide-induced sepsis]. Kang H, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2022 Sep 20. PMID 36210711, Free PMC Article
    2. CB2 receptors modulate seizure-induced expression of pro-inflammatory cytokines in the hippocampus but not neocortex. Karan AA, et al. Mol Neurobiol, 2021 Aug. PMID 33907944
    3. CB2 Receptors and Neuron-Glia Interactions Modulate Neurotoxicity Generated by MAGL Inhibition. Rojo-Bustamante E, et al. Biomolecules, 2020 Aug 18. PMID 32824740, Free PMC Article
    4. CB2R induces a protective response against epileptic seizures through ERK and p38 signaling pathways. Cao Q, et al. Int J Neurosci, 2021 Aug. PMID 32715907
    5. Cannabinoid CB(2) receptors mediate the anxiolytic-like effects of monoacylglycerol lipase inhibition in a rat model of predator-induced fear. Ivy D, et al. Neuropsychopharmacology, 2020 Jul. PMID 32375160, Free PMC Article

    See all (106) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of a novel fatty acid binding protein-5-CB2 receptor-dependent mechanism regulating anxiety behaviors in the prefrontal cortex.
      Title: Identification of a novel fatty acid binding protein-5-CB2 receptor-dependent mechanism regulating anxiety behaviors in the prefrontal cortex.
    2. [Activation of cannabinoid receptor 2 alleviates acute lung injury in rats with lipopolysaccharide-induced sepsis].
      Title: [Activation of cannabinoid receptor 2 alleviates acute lung injury in rats with lipopolysaccharide-induced sepsis].
    3. CB2 receptors modulate seizure-induced expression of pro-inflammatory cytokines in the hippocampus but not neocortex.
      Title: CB2 receptors modulate seizure-induced expression of pro-inflammatory cytokines in the hippocampus but not neocortex.
    4. CB2R induces a protective response against epileptic seizures through ERK and p38 signaling pathways.
      Title: CB2R induces a protective response against epileptic seizures through ERK and p38 signaling pathways.
    5. Altered cannabinoid receptor expression in pancreatic islets in experimental model of uraemia.
      Title: Altered cannabinoid receptor expression in pancreatic islets in experimental model of uraemia.
    6. Cannabinoid CB2 receptors mediate the anxiolytic-like effects of monoacylglycerol lipase inhibition in a rat model of predator-induced fear.
      Title: Cannabinoid CB(2) receptors mediate the anxiolytic-like effects of monoacylglycerol lipase inhibition in a rat model of predator-induced fear.
    7. CB2 Receptors and Neuron-Glia Interactions Modulate Neurotoxicity Generated by MAGL Inhibition.
      Title: CB2 Receptors and Neuron-Glia Interactions Modulate Neurotoxicity Generated by MAGL Inhibition.
    8. Cannabinoid Receptors Overexpression in a Rat Model of Irritable Bowel Syndrome (IBS) after Treatment with a Ketogenic Diet.
      Title: Cannabinoid Receptors Overexpression in a Rat Model of Irritable Bowel Syndrome (IBS) after Treatment with a Ketogenic Diet.
    9. JWH133 inhibits MPP(+)-induced inflammatory response and iron influx in astrocytes.
      Title: JWH133 inhibits MPP(+)-induced inflammatory response and iron influx in astrocytes.
    10. Antinociceptive effects of treadmill exercise in a rat model of Parkinson's disease: The role of cannabinoid and opioid receptors.
      Title: Antinociceptive effects of treadmill exercise in a rat model of Parkinson's disease: The role of cannabinoid and opioid receptors.
    Submit: New GeneRIF Correction See all GeneRIFs (90)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cannabinoid receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cannabinoid receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cannabinoid signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within leukocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of action potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mast cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of synaptic transmission, GABAergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to amphetamine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extrinsic component of cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cannabinoid receptor 2
    Names
    CB2 receptor
    cannabinoid receptor 2 (macrophage)
    peripheral cannabinoid receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164142.4 → NP_001157614.1  cannabinoid receptor 2 isoform 1

      See identical proteins and their annotated locations for NP_001157614.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q9EP74, Q9QZN9
      UniProtKB/TrEMBL
      C6G964, C6G965
      Conserved Domains (1) summary
      cd15341
      Location:34 → 310
      7tmA_CB2; cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001164143.3 → NP_001157615.1  cannabinoid receptor 2 isoform 1

      See identical proteins and their annotated locations for NP_001157615.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q9EP74, Q9QZN9
      UniProtKB/TrEMBL
      C6G964, C6G965
      Related
      ENSRNOP00000066697.1, ENSRNOT00000074998.4
      Conserved Domains (1) summary
      cd15341
      Location:34 → 310
      7tmA_CB2; cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_001429701.1 → NP_001416630.1  cannabinoid receptor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q9EP74, Q9QZN9
      UniProtKB/TrEMBL
      C6G964, C6G965

    4. NM_020543.4 → NP_065418.3  cannabinoid receptor 2 isoform 2

      See identical proteins and their annotated locations for NP_065418.3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6IT74
      Related
      ENSRNOP00000012342.2, ENSRNOT00000012342.6
      Conserved Domains (1) summary
      cd15341
      Location:34 → 310
      7tmA_CB2; cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      153408968..153435092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288330.1 → XP_063144400.1  cannabinoid receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9EP74, Q9QZN9
      UniProtKB/TrEMBL
      C6G964, C6G965

    2. XM_063288329.1 → XP_063144399.1  cannabinoid receptor 2 isoform X1

      Related
      ENSRNOP00000078684.1, ENSRNOT00000114527.2

    3. XM_039110690.2 → XP_038966618.1  cannabinoid receptor 2 isoform X2

      UniProtKB/TrEMBL
      A6IT74
      Conserved Domains (1) summary
      cd15341
      Location:34 → 310
      7tmA_CB2; cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RNA

    1. XR_010066464.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZN9.3 GenPept UniProtKB/Swiss-Prot:Q9QZN9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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