Cacna1i calcium voltage-gated channel subunit alpha1 I [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cacna1iprovided by RGD
Official Full Name: calcium voltage-gated channel subunit alpha1 Iprovided by RGD
Primary source: RGD:68944
See related: EnsemblRapid:ENSRNOG00000060407 AllianceGenome:RGD:68944
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables low voltage-gated calcium channel activity. Involved in calcium ion import and calcium ion transport into cytosol. Acts upstream of or within calcium ion transport and regulation of membrane potential. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in neuron projection. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human CACNA1I (calcium voltage-gated channel subunit alpha1 I). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 56.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (113716266..113827670)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (111835996..111947418)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (121521787..121619300)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel phospho-modulatory mechanism contributes to the calcium-dependent regulation of T-type Ca(2+) channels.
Title: A novel phospho-modulatory mechanism contributes to the calcium-dependent regulation of T-type Ca(2+) channels.
Cav3.3 overexpression aggravated DRG injury induced by ropivacaine hydrochloride and inhibition of Cav3.3 expression improved the cell damages. Cav3.3 can regulate CaMKIIgamma mRNA and protein expression.
Title: In vitro neurotoxicity by ropivacaine is reduced by silencing Cav3.3 T-type calcium subunits in neonatal rat sensory neurons.
Extracellular pressure increases [Ca(2+)]i via Cav3.3, driving a PKC-beta- IKK- IkB-NF-kB pathway that stimulates cancer cell proliferation
Title: Increased extracellular pressure stimulates tumor proliferation by a mechanosensitive calcium channel and PKC-β.
Results suggest that T-type Ca channels Cav3.1, Cav3.2 and Cav3.3 are potential therapeutic targets for the treatment of spinal nerve ligation-induced neuropathic pain.
Title: Upregulation of T-type Ca2+ channels in primary sensory neurons in spinal nerve injury.
Important link between pressure-mediated exacerbation of infarct size and T-type Ca2+ channel activity.
Title: Mechanisms underlying afterload-induced exacerbation of myocardial infarct size: role of T-type Ca2+ channel.
T-type alpha1H Ca2+ channels (Ca(v)3.2) in major pelvic ganglion neurons.
Title: Identification of T-type alpha1H Ca2+ channels (Ca(v)3.2) in major pelvic ganglion neurons.
T-type Ca2+ channels appear to be essential for the initiation of the spontaneous activity in mammalian bipolar cells.
Title: Spontaneous regenerative activity in mammalian retinal bipolar cells: roles of multiple subtypes of voltage-dependent Ca2+ channels.
alternative splicing produces channels with distinct properties
Title: Alternative splicing of the rat Ca(v)3.3 T-type calcium channel gene produces variants with distinct functional properties(1).

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables low voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables low voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium ion import	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion import	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transport into cytosol	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane depolarization during action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuronal action potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion-dependent exocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in sleep	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sleep	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated calcium channel complex	IC Inferred by Curator more info	PubMed
part_of voltage-gated calcium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated sodium channel complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: voltage-dependent T-type calcium channel subunit alpha-1I

Names: caVT.3; calcium channel, voltage-dependent, T type, alpha 1I subunit; calcium channel, voltage-dependent, alpha 1I subunit; hypothetical gene supported by NM_020084; low voltage-activated T-type calcium channel alpha-1 subunit (CACNA1I); voltage-dependent calcium channel; voltage-gated calcium channel subunit alpha Cav3.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020084.4 → NP_064469.4 voltage-dependent T-type calcium channel subunit alpha-1I

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I5ZQK3, A0A8I6APG9

Related

ENSRNOP00000080577.2, ENSRNOT00000092608.3

Conserved Domains (2) summary

PHA03307
Location:1840 → 2195

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:597 → 824

Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

113716266..113827670

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063264170.1 → XP_063120240.1 voltage-dependent T-type calcium channel subunit alpha-1I isoform X4
XM_063264168.1 → XP_063120238.1 voltage-dependent T-type calcium channel subunit alpha-1I isoform X2

UniProtKB/TrEMBL

A0A8I5ZQK3

Related

ENSRNOP00000095801.1, ENSRNOT00000084352.3
XM_063264167.1 → XP_063120237.1 voltage-dependent T-type calcium channel subunit alpha-1I isoform X1
XM_063264169.1 → XP_063120239.1 voltage-dependent T-type calcium channel subunit alpha-1I isoform X3

Related

ENSRNOP00000104426.1, ENSRNOT00000144089.1