Showing Current items.

Prkn parkin RBR E3 ubiquitin protein ligase [ Rattus norvegicus (Norway rat) ]

Gene ID: 56816, updated on 17-Aug-2024

Summary

Go to the top of the page Help

Official Symbol: Prknprovided by RGD
Official Full Name: parkin RBR E3 ubiquitin protein ligaseprovided by RGD
Primary source: RGD:61797
See related: EnsemblRapid:ENSRNOG00000055547 AllianceGenome:RGD:61797
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Park; Park2
Summary: Enables protein kinase binding activity. Involved in several processes, including cellular response to amino acid stimulus; negative regulation of neuron death; and negative regulation of synaptic transmission. Acts upstream of or within negative regulation of neuron death. Located in several cellular components, including bounding membrane of organelle; membrane raft; and postsynaptic density. Colocalizes with mitochondrion. Used to study Parkinson's disease. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 2; and ovarian cancer. Orthologous to human PRKN (parkin RBR E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 59.2), Muscle (RPKM 59.2) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

Location:: 1q11

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (51236410..52430242, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (48688651..49882520, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (48880015..50069998, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deciphering the neuroprotective mechanisms of RACK1 in cerebral ischemia-reperfusion injury: Pioneering insights into mitochondrial autophagy and the PINK1/Parkin axis.
Title: Deciphering the neuroprotective mechanisms of RACK1 in cerebral ischemia-reperfusion injury: Pioneering insights into mitochondrial autophagy and the PINK1/Parkin axis.
Low Selenium and Low Protein Exacerbate Myocardial Damage in Keshan Disease by Affecting the PINK1/Parkin-mediated Mitochondrial Autophagy Pathway.
Title: Low Selenium and Low Protein Exacerbate Myocardial Damage in Keshan Disease by Affecting the PINK1/Parkin-mediated Mitochondrial Autophagy Pathway.
The Role of Parkin in Rat Pancreatic Beta Cells Fate.
Title: The Role of Parkin in Rat Pancreatic Beta Cells Fate.
Structure-based design and characterization of Parkin-activating mutations.
Title: Structure-based design and characterization of Parkin-activating mutations.
Hypoxic postconditioning restores mitophagy against transient global cerebral ischemia via Parkin-induced posttranslational modification of TBK1.
Title: Hypoxic postconditioning restores mitophagy against transient global cerebral ischemia via Parkin-induced posttranslational modification of TBK1.
Effect of Thyroxine on the Structural and Dynamic Features of Cardiac Mitochondria and Mitophagy in Rats.
Title: Effect of Thyroxine on the Structural and Dynamic Features of Cardiac Mitochondria and Mitophagy in Rats.
O-linked N-acetylglucosamine affects mitochondrial homeostasis by regulating Parkin-dependent mitophagy in hyperoxia-injured alveolar type II cells injury.
Title: O-linked N-acetylglucosamine affects mitochondrial homeostasis by regulating Parkin-dependent mitophagy in hyperoxia-injured alveolar type II cells injury.
The mitochondria-targeted antioxidant MitoQ ameliorates myocardial ischemia-reperfusion injury by enhancing PINK1/Parkin-mediated mitophagy in type 2 diabetic rats.
Title: The mitochondria-targeted antioxidant MitoQ ameliorates myocardial ischemia-reperfusion injury by enhancing PINK1/Parkin-mediated mitophagy in type 2 diabetic rats.
Parkin overexpression reduces inflammation-mediated cardiomyocyte apoptosis through activating Nrf2/ARE signaling pathway.
Title: Parkin overexpression reduces inflammation-mediated cardiomyocyte apoptosis through activating Nrf2/ARE signaling pathway.
Parkin-deficient rats are resistant to neurotoxicity of chronic high-dose methamphetamine.
Title: Parkin-deficient rats are resistant to neurotoxicity of chronic high-dose methamphetamine.

Submit: New GeneRIF Correction See all GeneRIFs (61)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

D1Rat17 (e-PCR)
- UniSTS:118537

d1rat228 (e-PCR)
- UniSTS:120330

D1Rat18 (e-PCR)
- UniSTS:118542

RH134081 (e-PCR)
- UniSTS:217363

D1Got61 (e-PCR)
- UniSTS:113712

AI171223 (e-PCR)
- UniSTS:250477

BE097220 (e-PCR)
- UniSTS:244620

BE120978 (e-PCR)
- UniSTS:247489

d1mit9 (e-PCR)
- UniSTS:120265

D1Mgh4 (e-PCR)
- UniSTS:118496

D1Rat143 (e-PCR), detects polymorphism
- UniSTS:227041

D1Rat19 (e-PCR), detects polymorphism
- UniSTS:227053

D1Rat191 (e-PCR), detects polymorphism
- UniSTS:227054

AU048432 (e-PCR)
- UniSTS:144882

BE107128 (e-PCR)
- UniSTS:246771

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables F-box domain binding	IEA Inferred from Electronic Annotation more info
enables F-box domain binding	ISO Inferred from Sequence Orthology more info
enables F-box domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables Hsp70 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables cullin family protein binding	IEA Inferred from Electronic Annotation more info
enables cullin family protein binding	ISO Inferred from Sequence Orthology more info
enables cullin family protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables phospholipase binding	IEA Inferred from Electronic Annotation more info
enables phospholipase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables tubulin binding	IEA Inferred from Electronic Annotation more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin conjugating enzyme binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-specific protease binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-specific protease binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adult locomotory behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adult locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in adult locomotory behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in aggresome assembly	IEA Inferred from Electronic Annotation more info
involved_in aggresome assembly	ISO Inferred from Sequence Orthology more info
involved_in aggresome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy of mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in autophagy of mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to L-glutamate	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to L-glutamine	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hydrogen sulfide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to manganese ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to toxic substance	IEA Inferred from Electronic Annotation more info
involved_in cellular response to toxic substance	ISO Inferred from Sequence Orthology more info
involved_in cellular response to toxic substance	ISS Inferred from Sequence or Structural Similarity more info
involved_in dopamine metabolic process	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within dopamine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dopamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in dopamine uptake involved in synaptic transmission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dopamine uptake involved in synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in free ubiquitin chain polymerization	IEA Inferred from Electronic Annotation more info
involved_in free ubiquitin chain polymerization	ISO Inferred from Sequence Orthology more info
involved_in learning	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within learning	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial fragmentation involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion localization	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion to lysosome vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion to lysosome vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in mitophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in mitophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitophagy	ISO Inferred from Sequence Orthology more info
involved_in mitophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation by host of viral genome replication	IEA Inferred from Electronic Annotation more info
involved_in negative regulation by host of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of actin filament bundle assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of exosomal secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of exosomal secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of intralumenal vesicle formation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intralumenal vesicle formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitochondrial fusion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of reactive oxygen species biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of release of cytochrome c from mitochondria	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of release of cytochrome c from mitochondria	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of spontaneous neurotransmitter secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of spontaneous neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in neuron cellular homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in norepinephrine metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within norepinephrine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	IEA Inferred from Electronic Annotation more info
involved_in parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ATP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of dendrite extension	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendrite extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial fusion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial fusion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitophagy	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitophagy in response to mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurotransmitter uptake	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neurotransmitter uptake	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein linear polyubiquitination	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein linear polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K11-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K11-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K11-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K48-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K6-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K6-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K6-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K63-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autoubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	IEA Inferred from Electronic Annotation more info
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to mitochondrion	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in protein localization to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in protein localization to mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein monoubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein monoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein monoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cellular response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of dopamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of dopamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle endocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation protein catabolic process at presynapse	IEA Inferred from Electronic Annotation more info
involved_in regulation protein catabolic process at presynapse	ISO Inferred from Sequence Orthology more info
involved_in response to corticosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to curcumin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in response to endoplasmic reticulum stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in response to muscle activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to unfolded protein	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in startle response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within startle response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synaptic transmission, dopaminergic	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
NOT part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in aggresome	IEA Inferred from Electronic Annotation more info
located_in aggresome	ISO Inferred from Sequence Orthology more info
located_in aggresome	ISS Inferred from Sequence or Structural Similarity more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in dopaminergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in dopaminergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in intracellular vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion-derived vesicle	IEA Inferred from Electronic Annotation more info
located_in mitochondrion-derived vesicle	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: E3 ubiquitin-protein ligase parkin

Names: Parkinson disease (autosomal recessive, juvenile) 2, parkin; parkin RBR E3 ubiquitin protein ligase 2; parkin variant SV5DEL; parkinson protein 2, E3 ubiquitin protein ligase

NP_064478.1

EC 2.3.2.31

XP_038944638.1

EC 2.3.2.31

XP_038944641.1

EC 2.3.2.31

XP_038944642.1

EC 2.3.2.31

XP_038944645.1

EC 2.3.2.31

XP_038944652.1

EC 2.3.2.31

XP_063128104.1

EC 2.3.2.31

XP_063128107.1

EC 2.3.2.31

XP_063128110.1

EC 2.3.2.31

XP_063128114.1

EC 2.3.2.31

XP_063128116.1

EC 2.3.2.31

XP_063128124.1

EC 2.3.2.31

XP_063128127.1

EC 2.3.2.31

XP_063128128.1

EC 2.3.2.31

XP_063128130.1

EC 2.3.2.31

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020093.1 → NP_064478.1 E3 ubiquitin-protein ligase parkin

See identical proteins and their annotated locations for NP_064478.1

Status: PROVISIONAL

Source sequence(s)

AB039878

UniProtKB/TrEMBL

A0A1S7IWU1

Related

ENSRNOP00000077507.2, ENSRNOT00000096213.2

Conserved Domains (4) summary

cd01798
Location:3 → 72

parkin_N; amino-terminal ubiquitin-like of parkin protein

smart00213
Location:1 → 72

UBQ; Ubiquitin homologues

smart00647
Location:313 → 375

IBR; In Between Ring fingers

pfam01485
Location:413 → 453

IBR; IBR domain, a half RING-finger domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

51236410..52430242 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272040.1 → XP_063128110.1 E3 ubiquitin-protein ligase parkin isoform X4

UniProtKB/TrEMBL

A0A8I6A5N7, D3JVU6
XM_063272046.1 → XP_063128116.1 E3 ubiquitin-protein ligase parkin isoform X8

UniProtKB/Swiss-Prot

Q8K5C3, Q8K5C4, Q8K5C5, Q8K5C6, Q8VHY6, Q9JK66, Q9JLL1, Q9JM64

UniProtKB/TrEMBL

A0A1S7IWU1, A6KJZ1

Related

ENSRNOP00000075137.3, ENSRNOT00000086127.3
XM_039088710.2 → XP_038944638.1 E3 ubiquitin-protein ligase parkin isoform X3

UniProtKB/TrEMBL

A0A8I6A5N7

Related

ENSRNOP00000070559.3, ENSRNOT00000089439.3

Conserved Domains (4) summary

cd01798
Location:3 → 76

Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins

pfam01485
Location:343 → 405

IBR; IBR domain, a half RING-finger domain

pfam17978
Location:258 → 348

zf-RING_14; RING/Ubox like zinc-binding domain

cd21382
Location:146 → 259

RING0_parkin; RING finger-like zinc-binding domain 0 of parkin
XM_039088724.2 → XP_038944652.1 E3 ubiquitin-protein ligase parkin isoform X10

UniProtKB/TrEMBL

S4X294

Related

ENSRNOP00000071167.2, ENSRNOT00000090521.3

Conserved Domains (3) summary

pfam01485
Location:148 → 210

IBR; IBR domain, a half RING-finger domain

pfam17978
Location:63 → 153

zf-RING_14; RING/Ubox like zinc-binding domain

cd21382
Location:6 → 64

RING0_parkin; RING finger-like zinc-binding domain 0 of parkin
XM_063272054.1 → XP_063128124.1 E3 ubiquitin-protein ligase parkin isoform X10

UniProtKB/TrEMBL

S4X294
XM_039088713.2 → XP_038944641.1 E3 ubiquitin-protein ligase parkin isoform X5

UniProtKB/TrEMBL

A0A8I6A5N7

Conserved Domains (4) summary

cd01798
Location:2 → 74

Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins

pfam01485
Location:341 → 403

IBR; IBR domain, a half RING-finger domain

pfam17978
Location:256 → 346

zf-RING_14; RING/Ubox like zinc-binding domain

cd21382
Location:144 → 257

RING0_parkin; RING finger-like zinc-binding domain 0 of parkin
XM_063272037.1 → XP_063128107.1 E3 ubiquitin-protein ligase parkin isoform X2

UniProtKB/TrEMBL

A0A8I6A5N7
XM_063272034.1 → XP_063128104.1 E3 ubiquitin-protein ligase parkin isoform X1

UniProtKB/TrEMBL

A0A8I6A5N7
XM_063272044.1 → XP_063128114.1 E3 ubiquitin-protein ligase parkin isoform X7

UniProtKB/Swiss-Prot

Q8K5C3, Q8K5C4, Q8K5C5, Q8K5C6, Q8VHY6, Q9JK66, Q9JLL1, Q9JM64

UniProtKB/TrEMBL

A0A1S7IWU1, A6KJZ1
XM_039088717.2 → XP_038944645.1 E3 ubiquitin-protein ligase parkin isoform X9

UniProtKB/TrEMBL

A0A8I6GIU4

Conserved Domains (4) summary

cd01798
Location:30 → 103

Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins

pfam01485
Location:312 → 374

IBR; IBR domain, a half RING-finger domain

pfam17978
Location:227 → 317

zf-RING_14; RING/Ubox like zinc-binding domain

cd21382
Location:173 → 228

RING0_parkin; RING finger-like zinc-binding domain 0 of parkin
XM_039088714.2 → XP_038944642.1 E3 ubiquitin-protein ligase parkin isoform X6

UniProtKB/Swiss-Prot

Q8K5C3, Q8K5C4, Q8K5C5, Q8K5C6, Q8VHY6, Q9JK66, Q9JLL1, Q9JM64

UniProtKB/TrEMBL

A6KJZ1

Related

ENSRNOP00000091214.2, ENSRNOT00000105555.2

Conserved Domains (4) summary

cd01798
Location:30 → 103

Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins

pfam01485
Location:340 → 402

IBR; IBR domain, a half RING-finger domain

pfam17978
Location:255 → 345

zf-RING_14; RING/Ubox like zinc-binding domain

cd21382
Location:173 → 256

RING0_parkin; RING finger-like zinc-binding domain 0 of parkin
XM_063272057.1 → XP_063128127.1 E3 ubiquitin-protein ligase parkin isoform X11

UniProtKB/TrEMBL

A6KJZ3, S4X294

Related

ENSRNOP00000072264.3, ENSRNOT00000083884.3
XM_063272060.1 → XP_063128130.1 E3 ubiquitin-protein ligase parkin isoform X13

UniProtKB/TrEMBL

A0A0G2JY87
XM_063272058.1 → XP_063128128.1 E3 ubiquitin-protein ligase parkin isoform X12