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    Ptges3 prostaglandin E synthase 3 [ Mus musculus (house mouse) ]

    Gene ID: 56351, updated on 1-Oct-2024

    Summary

    Official Symbol
    Ptges3provided by MGI
    Official Full Name
    prostaglandin E synthase 3provided by MGI
    Primary source
    MGI:MGI:1929282
    See related
    Ensembl:ENSMUSG00000071072 AllianceGenome:MGI:1929282
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p23; Tebp; Ptges; cPGES; sid3177; 5730442A20Rik
    Summary
    Enables DNA polymerase binding activity. Involved in positive regulation of telomerase activity; telomerase holoenzyme complex assembly; and telomere maintenance via telomerase. Acts upstream of or within several processes, including glucocorticoid receptor signaling pathway; glycogen biosynthetic process; and prostaglandin biosynthetic process. Predicted to be located in several cellular components, including actin filament; neuronal cell body; and perinuclear region of cytoplasm. Predicted to be part of chaperone complex and telomerase holoenzyme complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including liver and skin. Orthologous to human PTGES3 (prostaglandin E synthase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 32.9), adrenal adult (RPKM 31.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ptges3 in Genome Data Viewer
    Location:
    10 D3; 10 76.39 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127894851..127913123)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128058982..128077254)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9812 Neighboring gene DNA primase, p49 subunit Neighboring gene STARR-seq mESC enhancer starr_28254 Neighboring gene nascent polypeptide-associated complex alpha polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E5198 Neighboring gene STARR-positive B cell enhancer ABC_E10658 Neighboring gene predicted gene, 47438 Neighboring gene STARR-positive B cell enhancer ABC_E25 Neighboring gene small nucleolar RNA, C/D box 59A Neighboring gene ATP synthase F1 subunit beta Neighboring gene microRNA 677

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA polymerase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables DNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Hsp90 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables prostaglandin-E synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables prostaglandin-E synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables prostaglandin-E synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables telomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chaperone cofactor-dependent protein refolding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chaperone-mediated protein complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chaperone-mediated protein complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chaperone-mediated protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glycogen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung saccule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nuclear receptor-mediated glucocorticoid signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of telomere maintenance via telomerase IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in prostaglandin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in prostaglandin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within prostaglandin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prostaglandin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in prostaglandin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein stabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in telomerase holoenzyme complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in telomerase holoenzyme complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in telomerase holoenzyme complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomere maintenance via telomerase IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_positive_effect telomere maintenance via telomerase IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_positive_effect telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein folding chaperone complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein folding chaperone complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of telomerase holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of telomerase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    prostaglandin E synthase 3
    Names
    cytosolic prostaglandin E2 synthase
    hsp90 co-chaperone
    p23 cochaperone
    progesterone receptor complex p23
    prostaglandin E synthase 3 (cytosolic)
    sid 3177
    telomerase binding protein, p23
    NP_062740.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019766.4NP_062740.1  prostaglandin E synthase 3

      See identical proteins and their annotated locations for NP_062740.1

      Status: PROVISIONAL

      Source sequence(s)
      AC131120
      Consensus CDS
      CCDS36087.1
      UniProtKB/Swiss-Prot
      Q542V4, Q9D7V0, Q9R0Q7, Q9WV83
      UniProtKB/TrEMBL
      Q3TJG6
      Related
      ENSMUSP00000050292.8, ENSMUST00000052798.14
      Conserved Domains (1) summary
      cd00237
      Location:3109
      p23; p23 binds heat shock protein (Hsp)90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127894851..127913123
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)