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    hcrtr2 hypocretin (orexin) receptor 2 [ Danio rerio (zebrafish) ]

    Gene ID: 561260, updated on 2-Nov-2024

    Summary

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    Official Symbol
    hcrtr2provided by ZNC
    Official Full Name
    hypocretin (orexin) receptor 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070228-3
    See related
    Ensembl:ENSDARG00000023722 AllianceGenome:ZFIN:ZDB-GENE-070228-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hcrtr
    Summary
    Predicted to enable orexin receptor activity. Acts upstream of or within circadian behavior; melatonin metabolic process; and regulation of circadian sleep/wake cycle, sleep. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain and spinal cord. Orthologous to human HCRTR2 (hypocretin receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See hcrtr2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (2020215..2060671, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (1888924..1929380, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110440169 Neighboring gene 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1 Neighboring gene GDNF family receptor alpha like Neighboring gene family with sequence similarity 83 member B Neighboring gene uncharacterized LOC137487352

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Hierarchical Compression Reveals Sub-Second to Day-Long Structure in Larval Zebrafish Behavior. Ghosh M, et al. eNeuro, 2020 Jul/Aug. PMID 32241874, Free PMC Article
    2. Overlapping Distribution of Orexin and Endocannabinoid Receptors and Their Functional Interaction in the Brain of Adult Zebrafish. Imperatore R, et al. Front Neuroanat, 2018. PMID 30104964, Free PMC Article
    3. Exploratory bioinformatics study of lncRNAs in Alzheimer's disease mRNA sequences with application to drug development. Holden T, et al. Comput Math Methods Med, 2013. PMID 23662159, Free PMC Article
    4. Melatonin protects embryonic development and maintains sleep/wake behaviors from the deleterious effects of fluorene-9-bisphenol in zebrafish (Danio rerio). Mi P, et al. J Pineal Res, 2019 Jan. PMID 30269372
    5. Hypocretin/orexin overexpression induces an insomnia-like phenotype in zebrafish. Prober DA, et al. J Neurosci, 2006 Dec 20. PMID 17182791, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables orexin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables orexin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within circadian behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within circadian sleep/wake cycle process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within feeding behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within melatonin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of circadian sleep/wake cycle, sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    orexin receptor type 2
    Names
    hcrt receptor
    hypocretin orexin receptor
    hypocretin receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079868.1 → NP_001073337.1  orexin receptor type 2

      See identical proteins and their annotated locations for NP_001073337.1

      Status: PROVISIONAL

      Source sequence(s)
      EF122429
      UniProtKB/TrEMBL
      A0A8M1NC97, A1YQE3
      Related
      ENSDARP00000029101.7, ENSDART00000038434.8
      Conserved Domains (3) summary
      pfam00001
      Location:71 → 364
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam03827
      Location:390 → 424
      Orexin_rec2; Orexin receptor type 2
      cl21561
      Location:65 → 185
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      2020215..2060671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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