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    KIF27 kinesin family member 27 [ Homo sapiens (human) ]

    Gene ID: 55582, updated on 2-Nov-2024

    Summary

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    Official Symbol
    KIF27provided by HGNC
    Official Full Name
    kinesin family member 27provided by HGNC
    Primary source
    HGNC:HGNC:18632
    See related
    Ensembl:ENSG00000165115 MIM:611253; AllianceGenome:HGNC:18632
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene is a member of the KIF27 (kinesin 4) sub-family of the mammalian kinesin family. The gene is an ortholog of the Drosophila Cos2 gene, which plays an important role in the Hedgehog signaling pathway. The encoded protein contains an N-terminal motor domain which includes nucleotide-binding and microtubule-interacting regions, a stalk domain containing a predicted coiled coil motif and a C-terminal tail domain. Alternatively spliced transcript variants have been observed for this gene. Pseudogenes associated with this gene are located on chromosome 9. [provided by RefSeq, Dec 2012]
    Expression
    Broad expression in testis (RPKM 7.5), thyroid (RPKM 3.1) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KIF27 in Genome Data Viewer
    Location:
    9q21.32
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (83834099..83921432, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (95983785..96071752, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (86449014..86536347, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902191 Neighboring gene G kinase anchoring protein 1 Neighboring gene MPRA-validated peak7279 silencer Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:86419564-86420465 Neighboring gene MPRA-validated peak7280 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19978 Neighboring gene uncharacterized LOC101927552 Neighboring gene uncharacterized LOC124900638 Neighboring gene serine/arginine repetitive matrix protein 1-like Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:86535879-86536628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:86537243-86537747 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:86577603-86578233 Neighboring gene Q-nucleotide N-glycosylase 1 Neighboring gene heterogeneous nuclear ribonucleoprotein K Neighboring gene microRNA 7-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Kinesins and protein kinases: key players in the regulation of microtubule dynamics and organization. Daire V, et al. Arch Biochem Biophys, 2011 Jun 15. PMID 21345331
    2. Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemia. Sweetser DA, et al. Genes Chromosomes Cancer, 2005 Nov. PMID 16015647
    3. Structural insights into human Kif7, a kinesin involved in Hedgehog signalling. Klejnot M, et al. Acta Crystallogr D Biol Crystallogr, 2012 Feb. PMID 22281744, Free PMC Article
    4. Characterization of KIF7 gene in silico. Katoh Y, et al. Int J Oncol, 2004 Dec. PMID 15547730
    5. KIF27 is one of orthologs for Drosophila Costal-2. Katoh Y, et al. Int J Oncol, 2004 Dec. PMID 15547729

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • RP11-575L7.3, DKFZp434D0917

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in epithelial cilium movement involved in extracellular fluid movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of localization in cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ventricular system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271927.3 → NP_001258856.1  kinesin-like protein KIF27 isoform B

      See identical proteins and their annotated locations for NP_001258856.1

      Status: REVIEWED

      Source sequence(s)
      AL354733, AY237537, DC376766
      Consensus CDS
      CCDS65071.1
      UniProtKB/Swiss-Prot
      Q86VH2
      Related
      ENSP00000401688.1, ENST00000413982.5
      Conserved Domains (2) summary
      smart00129
      Location:5 → 348
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

    2. NM_001271928.3 → NP_001258857.1  kinesin-like protein KIF27 isoform C

      See identical proteins and their annotated locations for NP_001258857.1

      Status: REVIEWED

      Source sequence(s)
      AL354733, AY237538, DC376766
      Consensus CDS
      CCDS65072.1
      UniProtKB/Swiss-Prot
      Q86VH2
      Related
      ENSP00000333928.2, ENST00000334204.6
      Conserved Domains (5) summary
      smart00129
      Location:5 → 348
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1340
      Location:817 → 1100
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam13863
      Location:800 → 886
      DUF4200; Domain of unknown function (DUF4200)
      cl12013
      Location:713 → 859
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. NM_001354069.2 → NP_001340998.1  kinesin-like protein KIF27 isoform D

      Status: REVIEWED

      Source sequence(s)
      AL354733
      Conserved Domains (2) summary
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      cl25732
      Location:721 → 1098
      SMC_N; RecF/RecN/SMC N terminal domain

    4. NM_001354070.2 → NP_001340999.1  kinesin-like protein KIF27 isoform E

      Status: REVIEWED

      Source sequence(s)
      AL354733
      Conserved Domains (1) summary
      cl25732
      Location:241 → 603
      SMC_N; RecF/RecN/SMC N terminal domain

    5. NM_001354071.2 → NP_001341000.1  kinesin-like protein KIF27 isoform F

      Status: REVIEWED

      Source sequence(s)
      AL354733
      Conserved Domains (1) summary
      cl25732
      Location:241 → 550
      SMC_N; RecF/RecN/SMC N terminal domain

    6. NM_017576.4 → NP_060046.1  kinesin-like protein KIF27 isoform A

      See identical proteins and their annotated locations for NP_060046.1

      Status: REVIEWED

      Source sequence(s)
      AL354733, AY237536, DC376766
      Consensus CDS
      CCDS6665.1
      UniProtKB/Swiss-Prot
      B2RTR8, Q5T6W0, Q86VH0, Q86VH1, Q86VH2, Q9UF54
      Related
      ENSP00000297814.2, ENST00000297814.7
      Conserved Domains (3) summary
      smart00129
      Location:5 → 348
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam13863
      Location:800 → 884
      DUF4200; Domain of unknown function (DUF4200)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      83834099..83921432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011518848.4 → XP_011517150.1  kinesin-like protein KIF27 isoform X1

      See identical proteins and their annotated locations for XP_011517150.1

      Conserved Domains (4) summary
      smart00129
      Location:5 → 348
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1340
      Location:820 → 1077
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam13863
      Location:826 → 910
      DUF4200; Domain of unknown function (DUF4200)

    2. XM_047423578.1 → XP_047279534.1  kinesin-like protein KIF27 isoform X9

    3. XM_047423577.1 → XP_047279533.1  kinesin-like protein KIF27 isoform X6

    4. XM_047423576.1 → XP_047279532.1  kinesin-like protein KIF27 isoform X5

    5. XM_017014904.2 → XP_016870393.1  kinesin-like protein KIF27 isoform X2

      UniProtKB/Swiss-Prot
      B2RTR8, Q5T6W0, Q86VH0, Q86VH1, Q86VH2, Q9UF54
      Conserved Domains (3) summary
      smart00129
      Location:5 → 348
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam13863
      Location:800 → 884
      DUF4200; Domain of unknown function (DUF4200)

    6. XM_011518849.3 → XP_011517151.1  kinesin-like protein KIF27 isoform X1

      See identical proteins and their annotated locations for XP_011517151.1

      Conserved Domains (4) summary
      smart00129
      Location:5 → 348
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1340
      Location:820 → 1077
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam13863
      Location:826 → 910
      DUF4200; Domain of unknown function (DUF4200)

    7. XM_047423574.1 → XP_047279530.1  kinesin-like protein KIF27 isoform X2

      UniProtKB/Swiss-Prot
      B2RTR8, Q5T6W0, Q86VH0, Q86VH1, Q86VH2, Q9UF54

    8. XM_017014900.2 → XP_016870389.1  kinesin-like protein KIF27 isoform X1

      Conserved Domains (4) summary
      smart00129
      Location:5 → 348
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1340
      Location:820 → 1077
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam13863
      Location:826 → 910
      DUF4200; Domain of unknown function (DUF4200)

    9. XM_047423571.1 → XP_047279527.1  kinesin-like protein KIF27 isoform X1

    10. XM_047423575.1 → XP_047279531.1  kinesin-like protein KIF27 isoform X2

      UniProtKB/Swiss-Prot
      B2RTR8, Q5T6W0, Q86VH0, Q86VH1, Q86VH2, Q9UF54

    11. XM_011518850.3 → XP_011517152.1  kinesin-like protein KIF27 isoform X1

      See identical proteins and their annotated locations for XP_011517152.1

      Conserved Domains (4) summary
      smart00129
      Location:5 → 348
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1340
      Location:820 → 1077
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam13863
      Location:826 → 910
      DUF4200; Domain of unknown function (DUF4200)

    12. XM_047423573.1 → XP_047279529.1  kinesin-like protein KIF27 isoform X2

      UniProtKB/Swiss-Prot
      B2RTR8, Q5T6W0, Q86VH0, Q86VH1, Q86VH2, Q9UF54

    13. XM_017014902.2 → XP_016870391.1  kinesin-like protein KIF27 isoform X1

      Conserved Domains (4) summary
      smart00129
      Location:5 → 348
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1340
      Location:820 → 1077
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam13863
      Location:826 → 910
      DUF4200; Domain of unknown function (DUF4200)

    14. XM_047423572.1 → XP_047279528.1  kinesin-like protein KIF27 isoform X2

      UniProtKB/Swiss-Prot
      B2RTR8, Q5T6W0, Q86VH0, Q86VH1, Q86VH2, Q9UF54

    15. XM_017014903.2 → XP_016870392.1  kinesin-like protein KIF27 isoform X2

      UniProtKB/Swiss-Prot
      B2RTR8, Q5T6W0, Q86VH0, Q86VH1, Q86VH2, Q9UF54
      Conserved Domains (3) summary
      smart00129
      Location:5 → 348
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam13863
      Location:800 → 884
      DUF4200; Domain of unknown function (DUF4200)

    16. XM_017014905.2 → XP_016870394.1  kinesin-like protein KIF27 isoform X3

      Conserved Domains (3) summary
      smart00129
      Location:5 → 348
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1340
      Location:874 → 1157
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

    17. XM_011518854.3 → XP_011517156.1  kinesin-like protein KIF27 isoform X7

      Conserved Domains (5) summary
      smart00129
      Location:5 → 348
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1842
      Location:779 → 997
      PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam13863
      Location:826 → 910
      DUF4200; Domain of unknown function (DUF4200)
      cl12013
      Location:739 → 885
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    18. XM_017014906.2 → XP_016870395.1  kinesin-like protein KIF27 isoform X4

      Conserved Domains (3) summary
      smart00129
      Location:5 → 348
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam13863
      Location:826 → 910
      DUF4200; Domain of unknown function (DUF4200)

    19. XM_047423570.1 → XP_047279526.1  kinesin-like protein KIF27 isoform X1

    20. XM_017014901.3 → XP_016870390.1  kinesin-like protein KIF27 isoform X1

      Conserved Domains (4) summary
      smart00129
      Location:5 → 348
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1340
      Location:820 → 1077
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam13863
      Location:826 → 910
      DUF4200; Domain of unknown function (DUF4200)

    21. XM_017014909.2 → XP_016870398.1  kinesin-like protein KIF27 isoform X8

    22. XM_047423579.1 → XP_047279535.1  kinesin-like protein KIF27 isoform X12

    23. XM_011518857.3 → XP_011517159.1  kinesin-like protein KIF27 isoform X11

      Conserved Domains (2) summary
      COG1196
      Location:389 → 751
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:604 → 912
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    24. XM_047423582.1 → XP_047279538.1  kinesin-like protein KIF27 isoform X15

    25. XM_011518856.3 → XP_011517158.1  kinesin-like protein KIF27 isoform X10

      Conserved Domains (4) summary
      smart00129
      Location:5 → 348
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1340
      Location:820 → 1077
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam13863
      Location:826 → 910
      DUF4200; Domain of unknown function (DUF4200)

    26. XM_047423580.1 → XP_047279536.1  kinesin-like protein KIF27 isoform X13

    27. XM_017014914.3 → XP_016870403.1  kinesin-like protein KIF27 isoform X14

    RNA

    1. XR_007061328.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      95983785..96071752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363253.1 → XP_054219228.1  kinesin-like protein KIF27 isoform X2

      UniProtKB/Swiss-Prot
      B2RTR8, Q5T6W0, Q86VH0, Q86VH1, Q86VH2, Q9UF54

    2. XM_054363251.1 → XP_054219226.1  kinesin-like protein KIF27 isoform X2

      UniProtKB/Swiss-Prot
      B2RTR8, Q5T6W0, Q86VH0, Q86VH1, Q86VH2, Q9UF54

    3. XM_054363256.1 → XP_054219231.1  kinesin-like protein KIF27 isoform X3

    4. XM_054363260.1 → XP_054219235.1  kinesin-like protein KIF27 isoform X7

    5. XM_054363257.1 → XP_054219232.1  kinesin-like protein KIF27 isoform X4

    6. XM_054363244.1 → XP_054219219.1  kinesin-like protein KIF27 isoform X1

    7. XM_054363262.1 → XP_054219237.1  kinesin-like protein KIF27 isoform X9

    8. XM_054363259.1 → XP_054219234.1  kinesin-like protein KIF27 isoform X6

    9. XM_054363258.1 → XP_054219233.1  kinesin-like protein KIF27 isoform X5

    10. XM_054363250.1 → XP_054219225.1  kinesin-like protein KIF27 isoform X2

      UniProtKB/Swiss-Prot
      B2RTR8, Q5T6W0, Q86VH0, Q86VH1, Q86VH2, Q9UF54

    11. XM_054363243.1 → XP_054219218.1  kinesin-like protein KIF27 isoform X1

    12. XM_054363254.1 → XP_054219229.1  kinesin-like protein KIF27 isoform X2

      UniProtKB/Swiss-Prot
      B2RTR8, Q5T6W0, Q86VH0, Q86VH1, Q86VH2, Q9UF54

    13. XM_054363247.1 → XP_054219222.1  kinesin-like protein KIF27 isoform X1

    14. XM_054363246.1 → XP_054219221.1  kinesin-like protein KIF27 isoform X1

    15. XM_054363248.1 → XP_054219223.1  kinesin-like protein KIF27 isoform X1

    16. XM_054363255.1 → XP_054219230.1  kinesin-like protein KIF27 isoform X2

      UniProtKB/Swiss-Prot
      B2RTR8, Q5T6W0, Q86VH0, Q86VH1, Q86VH2, Q9UF54

    17. XM_054363245.1 → XP_054219220.1  kinesin-like protein KIF27 isoform X1

    18. XM_054363252.1 → XP_054219227.1  kinesin-like protein KIF27 isoform X2

      UniProtKB/Swiss-Prot
      B2RTR8, Q5T6W0, Q86VH0, Q86VH1, Q86VH2, Q9UF54

    19. XM_054363249.1 → XP_054219224.1  kinesin-like protein KIF27 isoform X1

    20. XM_054363261.1 → XP_054219236.1  kinesin-like protein KIF27 isoform X8

    21. XM_054363265.1 → XP_054219240.1  kinesin-like protein KIF27 isoform X12

    22. XM_054363264.1 → XP_054219239.1  kinesin-like protein KIF27 isoform X11

    23. XM_054363268.1 → XP_054219243.1  kinesin-like protein KIF27 isoform X15

    24. XM_054363263.1 → XP_054219238.1  kinesin-like protein KIF27 isoform X10

    25. XM_054363266.1 → XP_054219241.1  kinesin-like protein KIF27 isoform X13

    26. XM_054363267.1 → XP_054219242.1  kinesin-like protein KIF27 isoform X14

    RNA

    1. XR_008488046.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86VH2.1 GenPept UniProtKB/Swiss-Prot:Q86VH2

    Gene LinkOut

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