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    Dgkb diacylglycerol kinase, beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54248, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Dgkbprovided by RGD
    Official Full Name
    diacylglycerol kinase, betaprovided by RGD
    Primary source
    RGD:2488
    See related
    EnsemblRapid:ENSRNOG00000030771 AllianceGenome:RGD:2488
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dagk; DGK-beta
    Summary
    Enables ATP-dependent diacylglycerol kinase activity. Involved in diacylglycerol metabolic process; lipid phosphorylation; and phosphatidic acid biosynthetic process. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Orthologous to human DGKB (diacylglycerol kinase beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 223.5), Heart (RPKM 36.9) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dgkb in Genome Data Viewer
    Location:
    6q21
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (60368101..61124420)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (54640948..55397210)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (57516351..58277385)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351363 Neighboring gene ribosomal protein S25 like 2 Neighboring gene actin, gamma 1, pseudogene 1 Neighboring gene thyroid hormone receptor-associated protein 3 pseudogene Neighboring gene uncharacterized LOC134479368 Neighboring gene phosphatidylethanolamine binding protein 1, pseudogene 2 Neighboring gene ETS variant transcription factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differential regulation of diacylglycerol kinase isozymes in cardiac hypertrophy. Yahagi H, et al. Biochem Biophys Res Commun, 2005 Jun 24. PMID 15896305
    2. Diacylglycerol kinase beta accumulates on the perisynaptic site of medium spiny neurons in the striatum. Hozumi Y, et al. Eur J Neurosci, 2008 Dec. PMID 19087171
    3. Diacylglycerol kinase beta promotes dendritic outgrowth and spine maturation in developing hippocampal neurons. Hozumi Y, et al. BMC Neurosci, 2009 Aug 19. PMID 19691842, Free PMC Article
    4. Molecular cloning and expression of a 90-kDa diacylglycerol kinase that predominantly localizes in neurons. Goto K, et al. Proc Natl Acad Sci U S A, 1993 Aug 15. PMID 7689223, Free PMC Article
    5. Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties. Caricasole A, et al. J Biol Chem, 2002 Feb 15. PMID 11719522

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study demonistrated that dgkb distribuate in rat cerebellum.
      Title: Differential distribution of phospholipase C beta isoforms and diaglycerol kinase-beta in rodents cerebella corroborates the division of unipolar brush cells into two major subtypes.
    2. The DGKbeta localize in the outer plexiform layer, within which photoreceptor cells make contact with bipolar and horizontal cells.
      Title: Distinct expression and localization of diacylglycerol kinase isozymes in rat retina.
    3. functional roles of DGK in the pituitary intermediate lobe
      Title: Signaling cascade of diacylglycerol kinase β in the pituitary intermediate lobe: dopamine D2 receptor/phospholipase Cβ4/diacylglycerol kinase β/protein kinase Cα.
    4. In the hippocampus, DGKbeta is expressed in both projection neurons and interneurons and is accumulated at the perisynapse of dendritic spines in asymmetrical synapses. It may be involved in dendrite outgrowth and spinogenesis.
      Title: Diacylglycerol kinase beta promotes dendritic outgrowth and spine maturation in developing hippocampal neurons.
    5. Data suggest that abundant diacylglycerol kinase beta is present perisynaptically in medium spiny neurons so that it can effectively produce phosphatidic acid upon activation of Gq-coupled receptors and modulate striatal output neurons.
      Title: Diacylglycerol kinase beta accumulates on the perisynaptic site of medium spiny neurons in the striatum.
    6. These results suggest that DGKepsilon and DGKzeta play distinct roles in the development of pressure overloaded cardiac hypertrophy and that the two isozymes are differentially regulated.
      Title: Differential regulation of diacylglycerol kinase isozymes in cardiac hypertrophy.
    7. In most brain regions, DGKbeta showed sustained expression throughout the postnatal developmental periods. And In the hippocampal pyramidal cell, DGKbeta localized along the membrane structure.
      Title: Immunocytochemical localization of a neuron-specific diacylglycerol kinase beta and gamma in the developing rat brain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in diacylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in diacylglycerol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycerolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipid phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidic acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynapse organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extrinsic component of postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    diacylglycerol kinase beta
    Names
    90 kDa diacylglycerol kinase
    DAG kinase beta
    Diacylglycerol kinase 90kDa
    diacylglycerol kinase beta, 90kDa
    diglyceride kinase beta
    NP_062177.2
    XP_008762871.2
    XP_017449817.1
    XP_017449818.1
    XP_017449819.1
    XP_063118430.1
    XP_063118431.1
    XP_063118432.1
    XP_063118433.1
    XP_063118434.1
    XP_063118435.1
    XP_063118436.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019304.2 → NP_062177.2  diacylglycerol kinase beta

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P49621
      UniProtKB/TrEMBL
      A6HBB8, F1LP01
      Related
      ENSRNOP00000058842.2, ENSRNOT00000063874.5
      Conserved Domains (6) summary
      smart00045
      Location:580 → 760
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:438 → 559
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:152 → 221
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:6 → 148
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20845
      Location:237 → 302
      C1_DGKbeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins
      cd20891
      Location:307 → 365
      C1_DGKbeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      60368101..61124420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262362.1 → XP_063118432.1  diacylglycerol kinase beta isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZWT2

    2. XM_017594328.3 → XP_017449817.1  diacylglycerol kinase beta isoform X1

      UniProtKB/Swiss-Prot
      P49621
      Conserved Domains (6) summary
      smart00045
      Location:581 → 761
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:439 → 560
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:152 → 221
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:6 → 148
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20845
      Location:237 → 302
      C1_DGKbeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins
      cd20891
      Location:307 → 365
      C1_DGKbeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins

    3. XM_063262364.1 → XP_063118434.1  diacylglycerol kinase beta isoform X5

    4. XM_017594330.3 → XP_017449819.1  diacylglycerol kinase beta isoform X3

      UniProtKB/Swiss-Prot
      P49621

    5. XM_063262366.1 → XP_063118436.1  diacylglycerol kinase beta isoform X6

    6. XM_063262360.1 → XP_063118430.1  diacylglycerol kinase beta isoform X2

      UniProtKB/TrEMBL
      A6HBB8, F1LP01

    7. XM_017594329.3 → XP_017449818.1  diacylglycerol kinase beta isoform X3

      UniProtKB/Swiss-Prot
      P49621
      Related
      ENSRNOP00000082015.2, ENSRNOT00000111621.2

    8. XM_008764649.4 → XP_008762871.2  diacylglycerol kinase beta isoform X1

      UniProtKB/Swiss-Prot
      P49621
      Conserved Domains (6) summary
      smart00045
      Location:581 → 761
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:439 → 560
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:152 → 221
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:6 → 148
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20845
      Location:237 → 302
      C1_DGKbeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins
      cd20891
      Location:307 → 365
      C1_DGKbeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins

    9. XM_063262363.1 → XP_063118433.1  diacylglycerol kinase beta isoform X5

    10. XM_063262361.1 → XP_063118431.1  diacylglycerol kinase beta isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZWT2
      Related
      ENSRNOP00000106123.1, ENSRNOT00000134799.1

    11. XM_063262365.1 → XP_063118435.1  diacylglycerol kinase beta isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49621.1 GenPept UniProtKB/Swiss-Prot:P49621

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