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    Cdkn2c cyclin-dependent kinase inhibitor 2C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54238, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cdkn2cprovided by RGD
    Official Full Name
    cyclin-dependent kinase inhibitor 2Cprovided by RGD
    Primary source
    RGD:2325
    See related
    EnsemblRapid:ENSRNOG00000008956 AllianceGenome:RGD:2325
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    p18
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding activity. Involved in oligodendrocyte differentiation. Predicted to be located in cytoplasm and nucleus. Orthologous to human CDKN2C (cyclin dependent kinase inhibitor 2C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 174.6), Spleen (RPKM 105.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdkn2c in Genome Data Viewer
    Location:
    5q35
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (129639736..129645564, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (124411123..124416278, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (129347731..129352886, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene enolase 1, pseudogene 10 Neighboring gene uncharacterized LOC134479085 Neighboring gene Fas associated factor 1 Neighboring gene doublesex and mab-3 related transcription factor like family A2, opposite strand like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Posttranscriptional regulation of p18 and p27 Cdk inhibitor proteins and the timing of oligodendrocyte differentiation. Tokumoto YM, et al. Dev Biol, 2002 May 1. PMID 11969268
    2. p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers. Pei XH, et al. Cancer Res, 2007 Apr 1. PMID 17409423
    3. Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Guan KL, et al. Genes Dev, 1994 Dec 15. PMID 8001816
    4. Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade and clinical outcome. Korshunov A, et al. Arch Pathol Lab Med, 2002 Jan. PMID 11800646
    5. Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity. Schreiber M, et al. Oncogene, 1999 Mar 4. PMID 10208428

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. posttranscriptional regulation
      Title: Posttranscriptional regulation of p18 and p27 Cdk inhibitor proteins and the timing of oligodendrocyte differentiation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligodendrocyte differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 4 inhibitor C
    Names
    cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429663.1 → NP_001416592.1  cyclin-dependent kinase 4 inhibitor C

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6JYZ6, A6JYZ7, Q8R5G3, Q8R5G4

    2. NM_001429664.1 → NP_001416593.1  cyclin-dependent kinase 4 inhibitor C

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6JYZ6, A6JYZ7, Q8R5G3, Q8R5G4

    3. NM_131902.5 → NP_571977.1  cyclin-dependent kinase 4 inhibitor C

      See identical proteins and their annotated locations for NP_571977.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6JYZ6, A6JYZ7, Q8R5G3, Q8R5G4
      Related
      ENSRNOP00000012088.4, ENSRNOT00000012088.9
      Conserved Domains (4) summary
      cd00204
      Location:37 → 156
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:9 → 100
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:89 → 144
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:37 → 67
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      129639736..129645564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288321.1 → XP_063144391.1  cyclin-dependent kinase 4 inhibitor C isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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