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    capn1 calpain 1, (mu/I) large subunit [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 541455, updated on 4-Nov-2024

    Summary

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    Official Symbol
    capn1provided by Xenbase
    Official Full Name
    calpain 1, (mu/I) large subunitprovided by Xenbase
    Primary source
    Xenbase:XB-GENE-990196
    See related
    Ensembl:ENSXETG00000023299 AllianceGenome:Xenbase:XB-GENE-990196
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    canp; mucl; canpl1; mucanp
    Summary
    Predicted to enable calcium ion binding activity and calcium-dependent cysteine-type endopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 76. Orthologous to human CAPN1 (calpain 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See capn1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 4 NC_030680.2 (31619747..31652080)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 4 NC_030680.1 (35461646..35493537)

    Chromosome 4 - NC_030680.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC116410342 Neighboring gene serine/threonine-protein kinase AtPK2/AtPK19-like Neighboring gene solute carrier family 22 member 20 Neighboring gene polymerase (DNA directed), alpha 2, accessory subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calpain-1 catalytic subunit
    NP_001013632.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013614.1 → NP_001013632.1  calpain-1 catalytic subunit

      See identical proteins and their annotated locations for NP_001013632.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081353
      UniProtKB/TrEMBL
      A0A6I8S9K3, A0A6I8SX43, F6TJS4, F7EUN5, Q66IH0
      Related
      ENSXETP00000094973.2, ENSXETT00000072619.2
      Conserved Domains (3) summary
      cd16198
      Location:545 → 713
      EFh_PEF_CAPN1; Penta-EF hand, calcium binding motifs, found in mu-type calpain (CAPN1)
      pfam00648
      Location:56 → 352
      Peptidase_C2; Calpain family cysteine protease
      pfam01067
      Location:373 → 518
      Calpain_III; Calpain large subunit, domain III

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030680.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      31619747..31652080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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