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    Tuba8 tubulin, alpha 8 [ Mus musculus (house mouse) ]

    Gene ID: 53857, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tuba8provided by MGI
    Official Full Name
    tubulin, alpha 8provided by MGI
    Primary source
    MGI:MGI:1858225
    See related
    Ensembl:ENSMUSG00000030137 AllianceGenome:MGI:1858225
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes a member of the tubulin family of cytoskeletal proteins that form the integral component of microtubules. This gene is preferentially expressed in heart, skeletal muscle and testis. The encoded protein may play a role in liver tumorigenesis in mice. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in testis adult (RPKM 94.0), heart adult (RPKM 37.0) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tuba8 in Genome Data Viewer
    Location:
    6 F1; 6 57.15 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (121187666..121209304)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (121210734..121226098)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 26 Neighboring gene predicted gene, 38651 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:121167996-121168280 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:121176131-121176438 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:121193284-121193537 Neighboring gene STARR-positive B cell enhancer ABC_E4859 Neighboring gene predicted gene, 44148 Neighboring gene ubiquitin specific peptidase 18 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:121222283-121222466 Neighboring gene solute carrier family 6 (neurotransmitter transporter, GABA), member 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TUBA8: A new tissue-specific isoform of alpha-tubulin that is highly conserved in human and mouse. Stanchi F, et al. Biochem Biophys Res Commun, 2000 Apr 21. PMID 10772959
    2. Mutation of the variant alpha-tubulin TUBA8 results in polymicrogyria with optic nerve hypoplasia. Abdollahi MR, et al. Am J Hum Genet, 2009 Nov. PMID 19896110, Free PMC Article
    3. Tubulin alpha 8 is expressed in hepatic stellate cells and is induced in transformed hepatocytes. Rein-Fischboeck L, et al. Mol Cell Biochem, 2017 Apr. PMID 28063004
    4. The role of Tuba1a in adult hippocampal neurogenesis and the formation of the dentate gyrus. Keays DA, et al. Dev Neurosci, 2010. PMID 21041996
    5. Alpha-syntrophin dependent expression of tubulin alpha 8 protein in hepatocytes. Rein-Fischboeck L, et al. J Physiol Biochem, 2018 Nov. PMID 30033487

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data (including data from studies conducted in knockout mice) suggest that Snta1 is involved in regulation of expression of Tuba8 in hepatocytes (but not in hepatic stellate cells); here, Snta1 protein levels are inversely related to Tuba8 protein expression in hepatocyte cell line. (Snta1 = syntrophin alpha-1; Tuba8 = tubulin alpha-8 chain)
      Title: Alpha-syntrophin dependent expression of tubulin alpha 8 protein in hepatocytes.
    2. Data provide evidence for a role of TUBA8 in hepatic fibrogenesis and malignancies making it a novel player in non-alcoholic steatohepatitis and hepatocellular carcinoma pathology.
      Title: Tubulin alpha 8 is expressed in hepatic stellate cells and is induced in transformed hepatocytes.
    3. TUBA8 can play a role in the regulation of cell growth, proliferation, and cell migration in a cell-specific manner in vitro.
      Title: Role of a novel CAR-induced gene, TUBA8, in hepatocellular carcinoma cell lines.
    4. Tuba8 is expressed at low levels in the developing mouse brain.
      Title: Tuba8 is expressed at low levels in the developing mouse and human brain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tubulin alpha-8 chain
    Names
    alpha tubulin 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017379.2 → NP_059075.1  tubulin alpha-8 chain

      See identical proteins and their annotated locations for NP_059075.1

      Status: REVIEWED

      Source sequence(s)
      AC153584, AJ245923, BC017631
      Consensus CDS
      CCDS39615.1
      UniProtKB/Swiss-Prot
      D4P911, Q9CV57, Q9JJZ2
      UniProtKB/TrEMBL
      A0A0A0MQA5
      Related
      ENSMUSP00000032233.8, ENSMUST00000032233.9
      Conserved Domains (1) summary
      PTZ00335
      Location:1 → 439
      PTZ00335; tubulin alpha chain; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      121187666..121209304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166283.1 → XP_036022176.1  tubulin alpha-8 chain isoform X1

      UniProtKB/TrEMBL
      Q99KA2
      Conserved Domains (1) summary
      PTZ00335
      Location:1 → 373
      PTZ00335; tubulin alpha chain; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJZ2.1 GenPept UniProtKB/Swiss-Prot:Q9JJZ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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