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    Vamp4 vesicle-associated membrane protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 53330, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Vamp4provided by MGI
    Official Full Name
    vesicle-associated membrane protein 4provided by MGI
    Primary source
    MGI:MGI:1858730
    See related
    Ensembl:ENSMUSG00000026696 AllianceGenome:MGI:1858730
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vamp-4; D1Ertd147e
    Summary
    Acts upstream of or within Golgi to plasma membrane protein transport; cellular response to type II interferon; and regulation of Golgi to plasma membrane protein transport. Located in phagocytic vesicle and trans-Golgi network. Part of SNARE complex. Is active in presynaptic endosome membrane. Is expressed in cerebellum layer; gonad; and ventral tegmental area. Orthologous to human VAMP4 (vesicle associated membrane protein 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 8.9), cortex adult (RPKM 8.4) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vamp4 in Genome Data Viewer
    Location:
    1 H2.1; 1 70.29 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (162398084..162426651)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (162570515..162599082)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46247 Neighboring gene methyltransferase 13, eEF1A lysine and N-terminal methyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E5839 Neighboring gene STARR-positive B cell enhancer ABC_E7767 Neighboring gene STARR-positive B cell enhancer ABC_E10051 Neighboring gene eukaryotic translation initiation factor 4E family member 1B pseudogene Neighboring gene myocilin Neighboring gene myocilin opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes. Ivanova D, et al. Sci Adv, 2021 Apr. PMID 33931449, Free PMC Article
    2. VAMP4 regulates insulin levels by targeting secretory granules to lysosomes. Li M, et al. J Cell Biol, 2022 Oct 3. PMID 36053215, Free PMC Article
    3. Neurite outgrowth induced by NGF or L1CAM via activation of the TrkA receptor is sustained also by the exocytosis of enlargeosomes. Colombo F, et al. Proc Natl Acad Sci U S A, 2014 Nov 25. PMID 25385598, Free PMC Article
    4. Cholesterol accumulation increases insulin granule size and impairs membrane trafficking. Bogan JS, et al. Traffic, 2012 Nov. PMID 22889194, Free PMC Article
    5. VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission. Raingo J, et al. Nat Neurosci, 2012 Mar 11. PMID 22406549, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cholesterol modulates Vamp4 distribution in insulin granule membranes.
      Title: Cholesterol accumulation increases insulin granule size and impairs membrane trafficking.
    2. The cytoplasmic domain of this protein is responsible for its correct subcellular targeting, the N-terminal extension contains a dominant autonomous targeting signal for the trans-golgi network
      Title: The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their correct subcellular targeting: the N-terminal extenSion of VAMP4 contains a dominant autonomous targeting signal for the trans-Golgi network.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in Golgi ribbon formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within Golgi to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in SNARE complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SNARE complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to type II interferon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of Golgi to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle to endosome fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vesicle-associated membrane protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347125.1 → NP_001334054.1  vesicle-associated membrane protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC138218
      Consensus CDS
      CCDS83616.1
      UniProtKB/Swiss-Prot
      O70480, Q9D095
      Related
      ENSMUSP00000115133.2, ENSMUST00000150040.8
      Conserved Domains (1) summary
      cd15869
      Location:50 → 116
      R-SNARE_VAMP4; SNARE motif of VAMP4

    2. NM_001356526.1 → NP_001343455.1  vesicle-associated membrane protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC138218
      Consensus CDS
      CCDS15421.1
      UniProtKB/TrEMBL
      Q8BSN6
      Related
      ENSMUSP00000121977.2, ENSMUST00000132158.8
      Conserved Domains (1) summary
      cd15869
      Location:50 → 116
      R-SNARE_VAMP4; SNARE motif of VAMP4

    3. NM_001356527.1 → NP_001343456.1  vesicle-associated membrane protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC138218
      Consensus CDS
      CCDS83616.1
      UniProtKB/Swiss-Prot
      O70480, Q9D095
      Related
      ENSMUSP00000116376.2, ENSMUST00000135241.8
      Conserved Domains (1) summary
      cd15869
      Location:50 → 116
      R-SNARE_VAMP4; SNARE motif of VAMP4

    4. NM_016796.3 → NP_058076.2  vesicle-associated membrane protein 4 isoform 1

      See identical proteins and their annotated locations for NP_058076.2

      Status: VALIDATED

      Source sequence(s)
      AK031151
      Consensus CDS
      CCDS15421.1
      UniProtKB/TrEMBL
      Q8BSN6
      Related
      ENSMUSP00000051544.5, ENSMUST00000050010.11
      Conserved Domains (1) summary
      cd15869
      Location:50 → 116
      R-SNARE_VAMP4; SNARE motif of VAMP4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      162398084..162426651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70480.1 GenPept UniProtKB/Swiss-Prot:O70480

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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