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    ZNF74 zinc finger protein 74 [ Bos taurus (domestic cattle) ]

    Gene ID: 509706, updated on 4-Oct-2024

    Summary

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    Official Symbol
    ZNF74provided by VGNC
    Official Full Name
    zinc finger protein 74provided by VGNC
    Primary source
    VGNC:VGNC:58432
    See related
    BGD:BT20076; Ensembl:ENSBTAG00000016257
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human all
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    Genomic context

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    See ZNF74 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (72542303..72553493, complement)

    Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene kelch like family member 22 Neighboring gene scavenger receptor class F member 2 Neighboring gene protein FAM246C Neighboring gene DiGeorge syndrome critical region gene 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 74

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206752.1 → NP_001193681.1  zinc finger protein 74

      Status: VALIDATED

      Source sequence(s)
      CR850826, DN532902, DV929841, DY088041, EE387538, EH178156
      Related
      ENSBTAP00000059524.2, ENSBTAT00000078009.2
      Conserved Domains (5) summary
      smart00349
      Location:36 → 95
      KRAB; krueppel associated box
      COG5048
      Location:268 → 529
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:36 → 75
      KRAB; KRAB box
      pfam13465
      Location:445 → 470
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      72542303..72553493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005218215.5 → XP_005218272.1  zinc finger protein 74 isoform X3

      UniProtKB/TrEMBL
      F1MSE6
      Related
      ENSBTAP00000029408.5, ENSBTAT00000029408.6
      Conserved Domains (5) summary
      smart00349
      Location:36 → 95
      KRAB; krueppel associated box
      COG5048
      Location:268 → 529
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:36 → 75
      KRAB; KRAB box
      pfam13465
      Location:445 → 470
      zf-H2C2_2; Zinc-finger double domain

    2. XM_010814220.4 → XP_010812522.1  zinc finger protein 74 isoform X4

      See identical proteins and their annotated locations for XP_010812522.1

      Conserved Domains (3) summary
      COG5048
      Location:204 → 465
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:397 → 417
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 31
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    3. XM_059875949.1 → XP_059731932.1  zinc finger protein 74 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1NIH9

    4. XM_059875948.1 → XP_059731931.1  zinc finger protein 74 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1NIH9

    5. XM_059875947.1 → XP_059731930.1  zinc finger protein 74 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1NIH9

    6. XM_059875946.1 → XP_059731929.1  zinc finger protein 74 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1NIH9

    7. XM_010814215.4 → XP_010812517.1  zinc finger protein 74 isoform X1

      See identical proteins and their annotated locations for XP_010812517.1

      UniProtKB/TrEMBL
      A0A3Q1NIH9
      Conserved Domains (5) summary
      smart00349
      Location:79 → 138
      KRAB; krueppel associated box
      COG5048
      Location:311 → 572
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:504 → 524
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:79 → 118
      KRAB; KRAB box
      pfam13465
      Location:488 → 513
      zf-H2C2_2; Zinc-finger double domain

    8. XM_059875950.1 → XP_059731933.1  zinc finger protein 74 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LVY8

    9. XM_059875952.1 → XP_059731935.1  zinc finger protein 74 isoform X4

    10. XM_059875951.1 → XP_059731934.1  zinc finger protein 74 isoform X4

    11. XM_010814214.4 → XP_010812516.1  zinc finger protein 74 isoform X1

      See identical proteins and their annotated locations for XP_010812516.1

      UniProtKB/TrEMBL
      A0A3Q1NIH9
      Related
      ENSBTAP00000071832.2, ENSBTAT00000070389.2
      Conserved Domains (5) summary
      smart00349
      Location:79 → 138
      KRAB; krueppel associated box
      COG5048
      Location:311 → 572
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:504 → 524
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:79 → 118
      KRAB; KRAB box
      pfam13465
      Location:488 → 513
      zf-H2C2_2; Zinc-finger double domain

    12. XM_015475612.3 → XP_015331098.1  zinc finger protein 74 isoform X4

      Related
      ENSBTAP00000094297.1, ENSBTAT00000089810.1
      Conserved Domains (3) summary
      COG5048
      Location:204 → 465
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:397 → 417
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 31
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    Nucleotide Protein Strain
    Heading Accession and Version

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