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    Prkn parkin RBR E3 ubiquitin protein ligase [ Mus musculus (house mouse) ]

    Gene ID: 50873, updated on 2-Nov-2024

    Summary

    Official Symbol
    Prknprovided by MGI
    Official Full Name
    parkin RBR E3 ubiquitin protein ligaseprovided by MGI
    Primary source
    MGI:MGI:1355296
    See related
    Ensembl:ENSMUSG00000023826 AllianceGenome:MGI:1355296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Park2
    Summary
    Enables ubiquitin protein ligase activity. Involved in several processes, including negative regulation of intrinsic apoptotic signaling pathway; positive regulation of dendrite extension; and positive regulation of protein linear polyubiquitination. Acts upstream of or within several processes, including catecholamine metabolic process; chemical synaptic transmission; and startle response. Located in mitochondrion; neuron projection; and nucleus. Part of protein-containing complex. Is active in dopaminergic synapse. Is expressed in several structures, including face; nervous system; pancreas; sensory organ; and skeleton. Used to study Parkinson's disease 2. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 2; lung cancer; and ovarian cancer. Orthologous to human PRKN (parkin RBR E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 1.6), cortex adult (RPKM 1.5) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Prkn in Genome Data Viewer
    Location:
    17 A1; 17 7.8 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (11059227..12282257)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (10840359..12063370)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene PARK2 co-regulated Neighboring gene STARR-seq mESC enhancer starr_41822 Neighboring gene STARR-seq mESC enhancer starr_41823 Neighboring gene STARR-seq mESC enhancer starr_41825 Neighboring gene predicted gene 16168 Neighboring gene STARR-seq mESC enhancer starr_41826 Neighboring gene STARR-seq mESC enhancer starr_41827 Neighboring gene predicted gene 16169 Neighboring gene uncharacterized protein C3orf18 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_41829 Neighboring gene STARR-seq mESC enhancer starr_41830 Neighboring gene predicted gene, 41526 Neighboring gene STARR-seq mESC enhancer starr_41831 Neighboring gene STARR-seq mESC enhancer starr_41832 Neighboring gene STARR-seq mESC enhancer starr_41833 Neighboring gene STARR-seq mESC enhancer starr_41834 Neighboring gene STARR-seq mESC enhancer starr_41835 Neighboring gene STARR-seq mESC enhancer starr_41837 Neighboring gene STARR-seq mESC enhancer starr_41838 Neighboring gene predicted gene, 41525 Neighboring gene STARR-seq mESC enhancer starr_41839 Neighboring gene DNA segment, Chr 17, ERATO Doi 648, expressed Neighboring gene STARR-seq mESC enhancer starr_41840 Neighboring gene STARR-seq mESC enhancer starr_41841 Neighboring gene predicted gene, 46604 Neighboring gene STARR-seq mESC enhancer starr_41845 Neighboring gene STARR-positive B cell enhancer ABC_E4192 Neighboring gene STARR-seq mESC enhancer starr_41846 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:12311592-12311701 Neighboring gene STARR-seq mESC enhancer starr_41847 Neighboring gene STARR-seq mESC enhancer starr_41848 Neighboring gene VISTA enhancer mm156 Neighboring gene STARR-positive B cell enhancer mm9_chr17:12398581-12398882 Neighboring gene teratocarcinoma-derived growth factor, pseudogene 2 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 4 Neighboring gene mitogen-activated protein kinase kinase kinase 4 Neighboring gene predicted gene, 46605

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC130518

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables F-box domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables F-box domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables PDZ domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cullin family protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin conjugating enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-specific protease binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-specific protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in aggresome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in aggresome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagy of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagy of mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to L-glutamate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hydrogen sulfide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to toxic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
     
    NOT acts_upstream_of_or_within dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dopamine uptake involved in synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in free ubiquitin chain polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in free ubiquitin chain polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    NOT acts_upstream_of_or_within learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial fission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrial fragmentation involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrion localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrion to lysosome vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrion to lysosome vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within mitophagy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in mitophagy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation by host of viral genome replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation by host of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of actin filament bundle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of exosomal secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of exosomal secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glucokinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of glucokinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of intralumenal vesicle formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of intralumenal vesicle formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mitochondrial fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of primary amine oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of primary amine oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of release of cytochrome c from mitochondria IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of spontaneous neurotransmitter secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of spontaneous neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron cellular homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within norepinephrine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ATP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendrite extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial fission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mitochondrial fusion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neurotransmitter uptake IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neurotransmitter uptake ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein linear polyubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein linear polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of type 2 mitophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K11-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K48-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K6-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K6-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein monoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein stabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cellular response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of dopamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of dopamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitochondrial membrane potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synaptic vesicle endocytosis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in regulation of synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation protein catabolic process at presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation protein catabolic process at presynapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in regulation protein catabolic process at presynapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within startle response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within synaptic transmission, dopaminergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in type 2 mitophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in type 2 mitophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in aggresome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in aggresome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in dopaminergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dopaminergic synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in dopaminergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion-derived vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with mitochondrion-derived vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase parkin
    Names
    Parkinson disease (autosomal recessive, juvenile) 2, parkin
    parkin protein
    NP_001304655.1
    NP_001390399.1
    NP_057903.1
    XP_006523400.1
    XP_006523402.1
    XP_017173061.1
    XP_017173062.1
    XP_017173065.1
    XP_030105754.1
    XP_036016575.1
    XP_036016576.1
    XP_036016577.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317726.2NP_001304655.1  E3 ubiquitin-protein ligase parkin isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) is shorter, and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC091254, AC091484, AC091777, AC093450, AC105305
      UniProtKB/TrEMBL
      A0A1W2P7W2
      Related
      ENSMUST00000186167.2
      Conserved Domains (2) summary
      cd01798
      Location:372
      parkin_N; amino-terminal ubiquitin-like of parkin protein
      smart00213
      Location:172
      UBQ; Ubiquitin homologues
    2. NM_001403470.1NP_001390399.1  E3 ubiquitin-protein ligase parkin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC091254, AC091484, AC091777, AC093450, AC105305, AC122259, AC163687, CT009575
    3. NM_016694.5NP_057903.1  E3 ubiquitin-protein ligase parkin isoform 1

      See identical proteins and their annotated locations for NP_057903.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC091254, AC091484, AC091777, AC093450, AC105305, AC122259, AC163687, CT009575
      Consensus CDS
      CCDS79506.1
      UniProtKB/Swiss-Prot
      Q2KHJ9, Q9ES22, Q9ES23, Q9WVS6
      Related
      ENSMUSP00000140587.2, ENSMUST00000191124.7
      Conserved Domains (4) summary
      cd01798
      Location:372
      parkin_N; amino-terminal ubiquitin-like of parkin protein
      smart00213
      Location:172
      UBQ; Ubiquitin homologues
      smart00647
      Location:313374
      IBR; In Between Ring fingers
      pfam01485
      Location:412452
      IBR; IBR domain, a half RING-finger domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      11059227..12282257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249894.2XP_030105754.1  E3 ubiquitin-protein ligase parkin isoform X8

      UniProtKB/TrEMBL
      A0A1W2P7W2
      Conserved Domains (3) summary
      cd01798
      Location:376
      Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
      pfam17976
      Location:144216
      zf-RING_12; RING/Ubox like zinc-binding domain
      pfam17978
      Location:227244
      zf-RING_14; RING/Ubox like zinc-binding domain
    2. XM_036160683.1XP_036016576.1  E3 ubiquitin-protein ligase parkin isoform X7

      Conserved Domains (2) summary
      cd01798
      Location:376
      Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
      cd21382
      Location:146206
      RING0_parkin; RING finger-like zinc-binding domain 0 of parkin
    3. XM_017317572.3XP_017173061.1  E3 ubiquitin-protein ligase parkin isoform X3

      Conserved Domains (4) summary
      smart00647
      Location:314375
      IBR; In Between Ring fingers
      cd01798
      Location:376
      Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
      pfam17976
      Location:145217
      zf-RING_12; RING/Ubox like zinc-binding domain
      pfam17978
      Location:228318
      zf-RING_14; RING/Ubox like zinc-binding domain
    4. XM_036160684.1XP_036016577.1  E3 ubiquitin-protein ligase parkin isoform X10

      UniProtKB/TrEMBL
      A0A1W2P7W2
      Related
      ENSMUSP00000156589.2, ENSMUST00000233294.2
      Conserved Domains (3) summary
      cd01798
      Location:376
      Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
      pfam17978
      Location:228246
      zf-RING_14; RING/Ubox like zinc-binding domain
      cd21382
      Location:146229
      RING0_parkin; RING finger-like zinc-binding domain 0 of parkin
    5. XM_017317576.3XP_017173065.1  E3 ubiquitin-protein ligase parkin isoform X9

      UniProtKB/TrEMBL
      B8YP90
      Conserved Domains (2) summary
      cd01798
      Location:376
      Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
      pfam17976
      Location:145206
      zf-RING_12; RING/Ubox like zinc-binding domain
    6. XM_006523339.4XP_006523402.1  E3 ubiquitin-protein ligase parkin isoform X6

      UniProtKB/TrEMBL
      A0A3B2W489
      Related
      ENSMUSP00000156810.2, ENSMUST00000233706.2
      Conserved Domains (3) summary
      pfam01485
      Location:123184
      IBR; IBR domain, a half RING-finger domain
      pfam17976
      Location:126
      zf-RING_12; RING/Ubox like zinc-binding domain
      pfam17978
      Location:37127
      zf-RING_14; RING/Ubox like zinc-binding domain
    7. XM_036160682.1XP_036016575.1  E3 ubiquitin-protein ligase parkin isoform X2

      Conserved Domains (5) summary
      smart00647
      Location:291352
      IBR; In Between Ring fingers
      pfam01485
      Location:390430
      IBR; IBR domain, a half RING-finger domain
      pfam17978
      Location:205295
      zf-RING_14; RING/Ubox like zinc-binding domain
      cd21382
      Location:123206
      RING0_parkin; RING finger-like zinc-binding domain 0 of parkin
      cl28922
      Location:3453
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    8. XM_006523337.4XP_006523400.1  E3 ubiquitin-protein ligase parkin isoform X4

      Conserved Domains (4) summary
      smart00647
      Location:183244
      IBR; In Between Ring fingers
      pfam01485
      Location:282322
      IBR; IBR domain, a half RING-finger domain
      pfam17976
      Location:1486
      zf-RING_12; RING/Ubox like zinc-binding domain
      pfam17978
      Location:97187
      zf-RING_14; RING/Ubox like zinc-binding domain
    9. XM_017317573.2XP_017173062.1  E3 ubiquitin-protein ligase parkin isoform X5

      Conserved Domains (4) summary
      smart00647
      Location:182243
      IBR; In Between Ring fingers
      pfam01485
      Location:281321
      IBR; IBR domain, a half RING-finger domain
      pfam17976
      Location:1385
      zf-RING_12; RING/Ubox like zinc-binding domain
      pfam17978
      Location:96186
      zf-RING_14; RING/Ubox like zinc-binding domain

    RNA

    1. XR_004939549.1 RNA Sequence

    2. XR_004939550.1 RNA Sequence