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    FAN1 FANCD2 and FANCI associated nuclease 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 508171, updated on 4-Oct-2024

    Summary

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    Official Symbol
    FAN1provided by VGNC
    Official Full Name
    FANCD2 and FANCI associated nuclease 1provided by VGNC
    Primary source
    VGNC:VGNC:28851
    See related
    Ensembl:ENSBTAG00000009855
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    MTMR15
    Orthologs
    human mouse all
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    Genomic context

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    See FAN1 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (27412429..27435334)

    Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene methylmalonyl-CoA epimerase Neighboring gene M-phase phosphoprotein 10 Neighboring gene myotubularin related protein 10 Neighboring gene uncharacterized LOC101902644

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A second generation radiation hybrid map to aid the assembly of the bovine genome sequence. Jann OC, et al. BMC Genomics, 2006 Nov 6. PMID 17087818, Free PMC Article
    2. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684
    3. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 5'-3' exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables 5'-flap endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables flap-structured DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in interstrand cross-link repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fanconi-associated nuclease 1
    Names
    FANCD2/FANCI-associated nuclease 1
    myotubularin related protein 15
    NP_001158142.1
    XP_005221927.1
    XP_005221928.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164670.1 → NP_001158142.1  fanconi-associated nuclease 1

      See identical proteins and their annotated locations for NP_001158142.1

      Status: VALIDATED

      Source sequence(s)
      BE480124, CK769657, CK831352, CO896626, CR382935, DV878134, DY466443, EW680984
      UniProtKB/TrEMBL
      A0A3Q1MGR3
      Related
      ENSBTAP00000062609.2, ENSBTAT00000086891.2
      Conserved Domains (2) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
      pfam08774
      Location:900 → 1014
      VRR_NUC; VRR-NUC domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      27412429..27435334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005221870.5 → XP_005221927.1  fanconi-associated nuclease 1 isoform X1

      See identical proteins and their annotated locations for XP_005221927.1

      UniProtKB/TrEMBL
      A0A3Q1MGR3
      Related
      ENSBTAP00000068227.2, ENSBTAT00000080475.2
      Conserved Domains (2) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
      pfam08774
      Location:900 → 1014
      VRR_NUC; VRR-NUC domain

    2. XM_005221871.5 → XP_005221928.1  fanconi-associated nuclease 1 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MGR3, F1MZ88
      Related
      ENSBTAP00000035073.4, ENSBTAT00000035195.5
      Conserved Domains (1) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
    Nucleotide Protein Strain
    Heading Accession and Version

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