Gjd2 gap junction protein, delta 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gjd2provided by RGD
Official Full Name: gap junction protein, delta 2provided by RGD
Primary source: RGD:2694
See related: AllianceGenome:RGD:2694
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cx36; Cxns; Gja9
Summary: Predicted to enable gap junction channel activity. Involved in cell-cell signaling. Located in gap junction. Orthologous to human GJD2 (gap junction protein delta 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 33.4) and Adrenal (RPKM 3.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (121226372..121229367, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (100771450..100776134, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (105467480..105470475, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of the gap junction protein connexin36 in small intensely fluorescent (SIF) cells in cardiac parasympathetic ganglia of rodents.
Title: Expression of the gap junction protein connexin36 in small intensely fluorescent (SIF) cells in cardiac parasympathetic ganglia of rodents.
Tubulin-dependent transport of Cx36 potentiates synaptic strength by delivering channels to Gap-junction plaques, reinforcing the role of protein transport at chemical and electrical synapses to fine-tune communication between neurons.
Title: Tubulin-Dependent Transport of Connexin-36 Potentiates the Size and Strength of Electrical Synapses.
Cx36-mediated junctional communication plays a crucial role in autoregulatory control of oxytocin neuronal activity
Title: Role of Connexin 36 in Autoregulation of Oxytocin Neuronal Activity in Rat Supraoptic Nucleus.
our findings demonstrated that Cx36 play an important role in mechanical allodynia by coupling GABA cells
Title: Electrical Synapses are Involved in Orofacial Neuropathic Pain.
these results suggest that leonurine might have a protective effect on OGD-induced PC12 cells through targeting the Cx36/CaMKII pathway. Thus, leonurine appears to have potential as a preventive or therapeutic drug against ischemic-induced neuronal injury.
Title: Neuroprotective effects of leonurine against oxygen-glucose deprivation by targeting Cx36/CaMKII in PC12 cells.
the protein expression levels of hippocampal Cx36 and Cx43 during epileptogenesis in the pilocarpine model of epilepsy, were examined.
Title: Hippocampal Expression of Connexin36 and Connexin43 during Epileptogenesis in Pilocarpine Model of Epilepsy.
activation of neuronal nicotinic receptors is an early tool for protecting motoneurons from excitotoxicity and that this process is carried out via the combined decrease in Cx36 activity, overexpression of Hsp70 and fall in AIF translocation
Title: Nicotine protects rat hypoglossal motoneurons from excitotoxic death via downregulation of connexin 36.
Cx45-puncta in the cerebellar molecular layer were co-localized with Cx36-puncta and additionally occurred along Bergmann glial processes adjacent to Cx43-puncta. Expression of both Cx43 and Cx45 in Bergmann glia of rat may contribute to the complex properties of junctional coupling between these cells and perhaps to their reported coupling with Purkinje cells.
Title: Cx36, Cx43 and Cx45 in mouse and rat cerebellar cortex: species-specific expression, compensation in Cx36 null mice and co-localization in neurons vs. glia.
The results of the present study revealed that during memory consolidation in a passive avoidance paradigm, a rapid upregulation of Cx36 mRNA level occurs in the hippocampus, which declines to the control level by 24 h after training.
Title: Rapid upregulation of the hippocampal connexins 36 and 45 mRNA levels during memory consolidation.
Neuronal Cx36 plays a role in rhythmic firing in substantia gelatinosa of rat neonatal dorsal horn in vitro.
Title: The role of Cx36 and Cx43 in 4-aminopyridine-induced rhythmic activity in the spinal nociceptive dorsal horn: an electrophysiological study in vitro.

Submit: New GeneRIF Correction See all GeneRIFs (40)

General gene information

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Markers

BB391717 (e-PCR)
- UniSTS:207377

NoName (e-PCR)
- UniSTS:480800

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables gap junction channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cell-cell signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of connexin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in gap junction	IDA Inferred from Direct Assay more info	PubMed
located_in gap junction	TAS Traceable Author Statement more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: gap junction delta-2 protein

Names: connexin s; connexin-36; gap junction alpha-9 protein; gap junction membrane channel protein alpha 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.