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    MERTK MER proto-oncogene, tyrosine kinase [ Bos taurus (domestic cattle) ]

    Gene ID: 504429, updated on 4-Oct-2024

    Summary

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    Official Symbol
    MERTKprovided by VGNC
    Official Full Name
    MER proto-oncogene, tyrosine kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:31391
    See related
    BGD:BT21183; Ensembl:ENSBTAG00000005828
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See MERTK in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (380816..516486, complement)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132346533 Neighboring gene fibulin 7 Neighboring gene transmembrane protein 87B Neighboring gene small nucleolar RNA SNORA70 Neighboring gene U6 spliceosomal RNA Neighboring gene anaphase promoting complex subunit 1 Neighboring gene putative speedy protein E7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase Mer
    Names
    c-mer proto-oncogene tyrosine kinase
    NP_001178953.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192024.2 → NP_001178953.2  tyrosine-protein kinase Mer precursor

      Status: VALIDATED

      Source sequence(s)
      AAFC03011359, AAFC03011360, AAFC03041117, AAFC03041118, AAFC03041119, AAFC03041120
      UniProtKB/TrEMBL
      A0AAA9SAX2, F1N381
      Related
      ENSBTAP00000007664.5, ENSBTAT00000007664.5
      Conserved Domains (7) summary
      cd00096
      Location:110 → 190
      Ig; Immunoglobulin domain
      cd05749
      Location:199 → 279
      Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)
      smart00410
      Location:100 → 193
      IG_like; Immunoglobulin like
      cd00063
      Location:284 → 378
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:197 → 280
      I-set; Immunoglobulin I-set domain
      cd14204
      Location:579 → 862
      PTKc_Mer; Catalytic Domain of the Protein Tyrosine Kinase, Mer
      pfam07714
      Location:587 → 854
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      380816..516486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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