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    Stradb STE20 related adaptor beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501146, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Stradbprovided by RGD
    Official Full Name
    STE20 related adaptor betaprovided by RGD
    Primary source
    RGD:1559449
    See related
    EnsemblRapid:ENSRNOG00000010728 AllianceGenome:RGD:1559449
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Als2cr2; RGD1559449
    Summary
    Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in activation of protein kinase activity and protein export from nucleus. Predicted to act upstream of or within JNK cascade; cell morphogenesis; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in aggresome; cytosol; and nucleus. Predicted to be part of serine/threonine protein kinase complex. Orthologous to human STRADB (STE20 related adaptor beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 287.0), Kidney (RPKM 204.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stradb in Genome Data Viewer
    Location:
    9q31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (67908277..67927224)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (60414182..60433084)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (65763437..65782513)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene flagellum associated containing coiled-coil domains 1 Neighboring gene uncharacterized LOC120094796 Neighboring gene trafficking kinesin protein 2 Neighboring gene transfer RNA valine (anticodon AAC) 15 Neighboring gene uncharacterized LOC120094795 Neighboring gene C2 calcium dependent domain containing 6 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in aggresome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in aggresome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of serine/threonine protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    STE20-related kinase adapter protein beta
    Names
    STE20-related kinase adaptor beta
    amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2
    polyploidy associated protein kinase PAPK-A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109307.2 → NP_001102777.2  STE20-related kinase adapter protein beta

      See identical proteins and their annotated locations for NP_001102777.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AK98, A6IP88, D3ZVH0
      Related
      ENSRNOP00000049160.2, ENSRNOT00000043558.4
      Conserved Domains (2) summary
      smart00220
      Location:58 → 369
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08226
      Location:59 → 386
      PK_STRAD_beta; Pseudokinase domain of STE20-related kinase adapter protein beta

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      67908277..67927224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084089.2 → XP_038940017.1  STE20-related kinase adapter protein beta isoform X1

      UniProtKB/TrEMBL
      A0A8I6AK98
      Conserved Domains (1) summary
      cl21453
      Location:59 → 357
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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