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    Tmem117 transmembrane protein 117 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500921, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Tmem117provided by RGD
    Official Full Name
    transmembrane protein 117provided by RGD
    Primary source
    RGD:1562562
    See related
    EnsemblRapid:ENSRNOG00000006068 AllianceGenome:RGD:1562562
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562562
    Summary
    Predicted to be involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum and plasma membrane. Orthologous to human TMEM117 (transmembrane protein 117). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Muscle (RPKM 122.3), Kidney (RPKM 88.2) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem117 in Genome Data Viewer
    Location:
    7q35
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (127636862..128098944)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (125757591..126219692)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (135880294..136403012)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit B4, pseudogene 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene twinfilin actin-binding protein 1 Neighboring gene uncharacterized LOC120093715 Neighboring gene uncharacterized LOC102546578 Neighboring gene neural EGFL like 2 Neighboring gene uncharacterized LOC134479780 Neighboring gene uncharacterized LOC120093716

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel transmembrane protein defines the endoplasmic reticulum stress-induced cell death pathway. Tamaki T, et al. Biochem Biophys Res Commun, 2017 Apr 22. PMID 28285135
    2. Intrinsic Disorder in Transmembrane Proteins: Roles in Signaling and Topology Prediction. Bürgi J, et al. PLoS One, 2016. PMID 27391701, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 117

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271239.1 → NP_001258168.1  transmembrane protein 117

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      F1LWX9
      Related
      ENSRNOP00000008159.7, ENSRNOT00000008159.8
      Conserved Domains (1) summary
      pfam15113
      Location:4 → 403
      TMEM117; TMEM117 protein family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      127636862..128098944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079771.2 → XP_038935699.1  transmembrane protein 117 isoform X1

    2. XM_063264145.1 → XP_063120215.1  transmembrane protein 117 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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