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    Mtbp MDM2 binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500870, updated on 2-Nov-2024

    Summary

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    Symbol
    Mtbpprovided by RGD
    Full Name
    MDM2 binding proteinprovided by RGD
    Primary source
    RGD:1565672
    See related
    EnsemblRapid:ENSRNOG00000004412 AllianceGenome:RGD:1565672
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565672
    Summary
    Predicted to be involved in protein localization to kinetochore and traversing start control point of mitotic cell cycle. Predicted to act upstream of or within negative regulation of cell population proliferation and negative regulation of mitotic nuclear division. Predicted to be located in chromatin. Predicted to be active in kinetochore. Orthologous to human MTBP (MDM2 binding protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 40.4), Thymus (RPKM 33.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mtbp in Genome Data Viewer
    Location:
    7q32
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (88862939..88945491)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (86973215..87055775)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (95309928..95392418)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene collagen type XIV alpha 1 chain Neighboring gene eukaryotic translation initiation factor 1, pseudogene 1 Neighboring gene mitochondrial ribosomal protein L13 Neighboring gene uncharacterized LOC120093658 Neighboring gene syntrophin, beta 1 Neighboring gene transfer RNA lysine (anticodon CUU) 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MTBP plays a crucial role in mitotic progression and chromosome segregation. Agarwal N, et al. Cell Death Differ, 2011 Jul. PMID 21274008, Free PMC Article
    2. A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2. Boyd MT, et al. J Biol Chem, 2000 Oct 13. PMID 10906133
    3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in traversing start control point of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within traversing start control point of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mdm2-binding protein
    Names
    Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein, 104kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130717.2 → NP_001124189.2  mdm2-binding protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6HRH7, D4AB60
      Related
      ENSRNOP00000005887.5, ENSRNOT00000005887.6
      Conserved Domains (3) summary
      pfam14918
      Location:1 → 270
      MTBP_N; MDM2-binding
      pfam14919
      Location:294 → 633
      MTBP_mid; MDM2-binding
      pfam14920
      Location:637 → 891
      MTBP_C; MDM2-binding

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      88862939..88945491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241656.5 → XP_006241718.1  mdm2-binding protein isoform X2

      See identical proteins and their annotated locations for XP_006241718.1

      UniProtKB/TrEMBL
      A6HRH7, D4AB60
      Related
      ENSRNOP00000100117.1, ENSRNOT00000141688.1
      Conserved Domains (3) summary
      pfam14918
      Location:1 → 270
      MTBP_N; MDM2-binding
      pfam14919
      Location:294 → 633
      MTBP_mid; MDM2-binding
      pfam14920
      Location:637 → 867
      MTBP_C; MDM2-binding

    2. XM_039079751.2 → XP_038935679.1  mdm2-binding protein isoform X3

      UniProtKB/TrEMBL
      A6HRH7, D4AB60
      Conserved Domains (3) summary
      pfam14918
      Location:1 → 270
      MTBP_N; MDM2-binding
      pfam14919
      Location:294 → 633
      MTBP_mid; MDM2-binding
      pfam14920
      Location:637 → 802
      MTBP_C; MDM2-binding

    3. XM_063264120.1 → XP_063120190.1  mdm2-binding protein isoform X1

    4. XM_039079754.2 → XP_038935682.2  mdm2-binding protein isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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