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    Msr1 macrophage scavenger receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498638, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Msr1provided by RGD
    Official Full Name
    macrophage scavenger receptor 1provided by RGD
    Primary source
    RGD:1564316
    See related
    EnsemblRapid:ENSRNOG00000012779 AllianceGenome:RGD:1564316
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564316
    Summary
    Predicted to enable amyloid-beta binding activity; cargo receptor activity; and low-density lipoprotein particle binding activity. Involved in cellular response to organic cyclic compound. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in Barrett's esophagus; arteriosclerosis; and prostate cancer. Orthologous to human MSR1 (macrophage scavenger receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 155.1), Liver (RPKM 138.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Msr1 in Genome Data Viewer
    Location:
    16q12.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (59421250..59507070)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (52717775..52803602)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (56817714..56900025, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene igE-binding protein-like Neighboring gene ribosomal protein S3, pseudogene 5 Neighboring gene G protein subunit beta 1, pseudogene 2 Neighboring gene U4 spliceosomal RNA Neighboring gene zinc finger protein 148, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Adeno-associated virus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor reduces atherosclerotic lesion formation in LDL receptor knockout mice. Jalkanen J, et al. Mol Ther, 2003 Dec. PMID 14664792
    2. Perindopril attenuates renal tubulointerstitium injury by inhibiting scavenger receptor A over-expression in diabetic rats. Sun L, et al. J Endocrinol Invest, 2012 May. PMID 21765240
    3. Potential effects of microglial activation induced by ginsenoside Rg3 in rat primary culture: enhancement of type A Macrophage Scavenger Receptor expression. Joo SS, et al. Arch Pharm Res, 2005 Oct. PMID 16276974
    4. Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression. Bak SP, et al. Cancer Res, 2007 May 15. PMID 17510407
    5. Dietary glycotoxins affect scavenger receptor expression and the hormonal profile of female rats. Chatzigeorgiou A, et al. J Endocrinol, 2013 Sep. PMID 23823020

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Heptapeptide XD4 activates the class A scavenger receptor (SR-A) on the glia by increasing the binding of Abeta to SR-A, thereby promoting glial phagocytosis of Abeta oligomer in astrocytes.
      Title: Activated scavenger receptor A promotes glial internalization of aβ.
    2. The expression of RAGE and Msr1 was significantly down-regulated in the high-AGE diet-fed rats.
      Title: Dietary glycotoxins affect scavenger receptor expression and the hormonal profile of female rats.
    3. Scavenger receptor A over-expression is associated with diabetes.
      Title: Perindopril attenuates renal tubulointerstitium injury by inhibiting scavenger receptor A over-expression in diabetic rats.
    4. Hook3 interacts with a cytoplasmic domain of scavenger receptor A
      Title: The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables amyloid-beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cargo receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables low-density lipoprotein particle binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables low-density lipoprotein particle binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amyloid-beta clearance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amyloid-beta clearance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipoprotein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in plasma lipoprotein particle clearance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma lipoprotein particle clearance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cholesterol storage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cholesterol storage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of macrophage derived foam cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    macrophage scavenger receptor types I and II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191939.2 → NP_001178868.1  macrophage scavenger receptor types I and II isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      D3ZDS2
      Related
      ENSRNOP00000104015.1, ENSRNOT00000147935.1
      Conserved Domains (4) summary
      pfam01391
      Location:288 → 345
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:353 → 453
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:358 → 453
      SRCR; Scavenger receptor cysteine-rich domain
      pfam03523
      Location:121 → 169
      Macscav_rec; Macrophage scavenger receptor

    2. NM_001411777.1 → NP_001398706.1  macrophage scavenger receptor types I and II isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      Related
      ENSRNOP00000105453.1, ENSRNOT00000172903.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      59421250..59507070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094773.2 → XP_038950701.1  macrophage scavenger receptor types I and II isoform X1

      UniProtKB/TrEMBL
      D3ZDS2
      Related
      ENSRNOP00000017339.8, ENSRNOT00000017339.9
      Conserved Domains (4) summary
      smart00202
      Location:408 → 491
      SR; Scavenger receptor Cys-rich
      pfam01391
      Location:343 → 397
      Collagen; Collagen triple helix repeat (20 copies)
      pfam03523
      Location:176 → 224
      Macscav_rec; Macrophage scavenger receptor
      pfam07426
      Location:170 → 277
      Dynactin_p22; Dynactin subunit p22
    Nucleotide Protein Strain
    Heading Accession and Version

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