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    Nrg3 neuregulin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498596, updated on 10-Oct-2024

    Summary

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    Symbol
    Nrg3provided by RGD
    Full Name
    neuregulin 3provided by RGD
    Primary source
    RGD:1559678
    See related
    EnsemblRapid:ENSRNOG00000063450 AllianceGenome:RGD:1559678
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559678
    Summary
    Predicted to enable chemorepellent activity. Predicted to be involved in modulation of chemical synaptic transmission. Predicted to act upstream of or within several processes, including intracellular signal transduction; mammary placode formation; and regulation of cell migration. Predicted to be integral component of membrane. Predicted to be active in glutamatergic synapse. Orthologous to human NRG3 (neuregulin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 66.6) and Brain (RPKM 50.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nrg3 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (14256540..15374107, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (14229270..15352505, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (15763031..16932208, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene elongin A, pseudogene 1 Neighboring gene elongin-A2-like 1 Neighboring gene uncharacterized LOC134482458 Neighboring gene uncharacterized LOC134482324 Neighboring gene uncharacterized LOC134482459 Neighboring gene uncharacterized LOC108348383 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase like 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Developmental expression of Neuregulin-3 in the rat central nervous system. Rahman A, et al. J Comp Neurol, 2019 Mar 1. PMID 30328115
    2. Neuregulin 3 Signaling Mediates Nicotine-Dependent Synaptic Plasticity in the Orbitofrontal Cortex and Cognition. Zhou L, et al. Neuropsychopharmacology, 2018 May. PMID 29114105, Free PMC Article
    3. The characterization of a mouse mutant that displays abnormal mammary gland development. Howard BA, et al. Mamm Genome, 2000 Mar. PMID 10723730
    4. Neuregulins and cancer. Montero JC, et al. Clin Cancer Res, 2008 Jun 1. PMID 18519747
    5. Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. Zhang D, et al. Proc Natl Acad Sci U S A, 1997 Sep 2. PMID 9275162, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chemorepellent activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERBB4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ERBB4-ERBB4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within chemorepulsion involved in interneuron migration from the subpallium to the cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mammary gland development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mammary placode formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within pattern specification process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pro-neuregulin-3, membrane-bound isoform

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433134.1 → NP_001420063.1  pro-neuregulin-3, membrane-bound isoform

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      14256540..15374107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275921.1 → XP_063131991.1  pro-neuregulin-3, membrane-bound isoform isoform X9

      Related
      ENSRNOP00000100753.1, ENSRNOT00000169124.1

    2. XM_039095029.2 → XP_038950957.1  pro-neuregulin-3, membrane-bound isoform isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y1H8
      Conserved Domains (1) summary
      PHA02887
      Location:285 → 338
      PHA02887; EGF-like protein; Provisional

    3. XM_039095033.2 → XP_038950961.1  pro-neuregulin-3, membrane-bound isoform isoform X8

      UniProtKB/TrEMBL
      A0A8I5Y1H8
      Conserved Domains (1) summary
      PHA02887
      Location:285 → 338
      PHA02887; EGF-like protein; Provisional

    4. XM_039095032.2 → XP_038950960.1  pro-neuregulin-3, membrane-bound isoform isoform X7

      Conserved Domains (1) summary
      PHA02887
      Location:285 → 338
      PHA02887; EGF-like protein; Provisional

    5. XM_039095028.2 → XP_038950956.1  pro-neuregulin-3, membrane-bound isoform isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y1H8
      Conserved Domains (1) summary
      PHA02887
      Location:285 → 338
      PHA02887; EGF-like protein; Provisional

    6. XM_039095031.2 → XP_038950959.1  pro-neuregulin-3, membrane-bound isoform isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y1H8
      Conserved Domains (1) summary
      PHA02887
      Location:285 → 338
      PHA02887; EGF-like protein; Provisional

    7. XM_039095027.2 → XP_038950955.1  pro-neuregulin-3, membrane-bound isoform isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y1H8
      Conserved Domains (1) summary
      PHA02887
      Location:285 → 338
      PHA02887; EGF-like protein; Provisional

    8. XM_039095030.2 → XP_038950958.1  pro-neuregulin-3, membrane-bound isoform isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y1H8, A0A8I5ZU04
      Related
      ENSRNOP00000080898.1, ENSRNOT00000111170.2
      Conserved Domains (1) summary
      PHA02887
      Location:285 → 338
      PHA02887; EGF-like protein; Provisional

    9. XM_017600398.3 → XP_017455887.2  pro-neuregulin-3, membrane-bound isoform isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y1H8
      Related
      ENSRNOP00000077709.2, ENSRNOT00000099299.2
      Conserved Domains (1) summary
      PHA02887
      Location:285 → 338
      PHA02887; EGF-like protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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