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    Mapkapk5 MAPK activated protein kinase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498183, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mapkapk5provided by RGD
    Official Full Name
    MAPK activated protein kinase 5provided by RGD
    Primary source
    RGD:1564113
    See related
    EnsemblRapid:ENSRNOG00000001345 AllianceGenome:RGD:1564113
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including calmodulin binding activity; p53 binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including Ras protein signal transduction; regulation of gene expression; and stress-induced premature senescence. Predicted to act upstream of or within positive regulation of dendritic spine development. Predicted to be located in cytosol; nucleoplasm; and septin cytoskeleton. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPKAPK5 (MAPK activated protein kinase 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 227.4), Thymus (RPKM 164.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mapkapk5 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (40654220..40673740)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (34993520..35013059)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (40510378..40529332)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA dehydrogenase family, member 10 Neighboring gene aldehyde dehydrogenase 2 family member Neighboring gene ADAM metallopeptidase domain 1a Neighboring gene transmembrane protein 116 Neighboring gene a disintegrin and metallopeptidase domain 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor. Kostenko S, et al. Cell Mol Life Sci, 2011 Jan. PMID 20640477, Free PMC Article
    2. The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis. Kress TR, et al. Mol Cell, 2011 Feb 18. PMID 21329882
    3. PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5. Kostenko S, et al. Cell Signal, 2009 May. PMID 19166925
    4. Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway. Seternes OM, et al. EMBO J, 2004 Dec 8. PMID 15577943, Free PMC Article
    5. Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5. Kant S, et al. J Biol Chem, 2006 Nov 17. PMID 16973613

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116327

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mitogen-activated protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of positive regulation of telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress-induced premature senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in septin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MAP kinase-activated protein kinase 5
    Names
    mitogen-activated protein kinase-activated protein kinase 5
    NP_001020932.2
    NP_001157515.1
    XP_038945629.1
    XP_038945631.1
    XP_038945632.1
    XP_063127655.1
    XP_063127656.1
    XP_063127657.1
    XP_063127658.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025761.2 → NP_001020932.2  MAP kinase-activated protein kinase 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI715466, BC099161
      UniProtKB/TrEMBL
      Q4KLJ9
      Conserved Domains (2) summary
      smart00220
      Location:1 → 203
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1 → 203
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001164043.1 → NP_001157515.1  MAP kinase-activated protein kinase 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AI715466, BC099161, FM032487
      UniProtKB/TrEMBL
      F1LN87
      Related
      ENSRNOP00000001817.6, ENSRNOT00000001817.9
      Conserved Domains (2) summary
      smart00220
      Location:26 → 304
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14171
      Location:15 → 304
      STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      40654220..40673740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089701.2 → XP_038945629.1  MAP kinase-activated protein kinase 5 isoform X5

      UniProtKB/TrEMBL
      F1LN87
      Conserved Domains (1) summary
      cd14171
      Location:15 → 304
      STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5

    2. XM_063271588.1 → XP_063127658.1  MAP kinase-activated protein kinase 5 isoform X6

    3. XM_063271585.1 → XP_063127655.1  MAP kinase-activated protein kinase 5 isoform X2

    4. XM_039089703.2 → XP_038945631.1  MAP kinase-activated protein kinase 5 isoform X1

      UniProtKB/TrEMBL
      F7FFP2, Q4KLJ9
      Related
      ENSRNOP00000061902.3, ENSRNOT00000065314.4
      Conserved Domains (1) summary
      cl21453
      Location:13 → 155
      PKc_like; Protein Kinases, catalytic domain

    5. XM_039089704.2 → XP_038945632.1  MAP kinase-activated protein kinase 5 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:1 → 124
      PKc_like; Protein Kinases, catalytic domain

    6. XM_063271587.1 → XP_063127657.1  MAP kinase-activated protein kinase 5 isoform X4

    7. XM_063271586.1 → XP_063127656.1  MAP kinase-activated protein kinase 5 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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