Mapkapk5 MAPK activated protein kinase 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mapkapk5provided by RGD
Official Full Name: MAPK activated protein kinase 5provided by RGD
Primary source: RGD:1564113
See related: EnsemblRapid:ENSRNOG00000001345 AllianceGenome:RGD:1564113
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including calmodulin binding activity; p53 binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including Ras protein signal transduction; regulation of gene expression; and stress-induced premature senescence. Predicted to act upstream of or within positive regulation of dendritic spine development. Predicted to be located in cytosol; nucleoplasm; and septin cytoskeleton. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPKAPK5 (MAPK activated protein kinase 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 227.4), Thymus (RPKM 164.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (40654220..40673740)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (34993520..35013059)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (40510378..40529332)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_4607-4608:966894545:1 (e-PCR)
- UniSTS:269407

RH139329 (e-PCR)
- UniSTS:221415

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium/calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables mitogen-activated protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TOR signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in stress-induced premature senescence	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in septin cytoskeleton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: MAP kinase-activated protein kinase 5

Names: mitogen-activated protein kinase-activated protein kinase 5

NP_001020932.2

EC 2.7.11.1

NP_001157515.1

EC 2.7.11.1

XP_038945629.1

EC 2.7.11.1

XP_038945631.1

EC 2.7.11.1

XP_038945632.1

EC 2.7.11.1

XP_063127655.1

EC 2.7.11.1

XP_063127656.1

EC 2.7.11.1

XP_063127657.1

EC 2.7.11.1

XP_063127658.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025761.2 → NP_001020932.2 MAP kinase-activated protein kinase 5 isoform 2

Status: VALIDATED

Source sequence(s)

AI715466, BC099161

UniProtKB/TrEMBL

Q4KLJ9

Conserved Domains (2) summary

smart00220
Location:1 → 203

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:1 → 203

PKc_like; Protein Kinases, catalytic domain
NM_001164043.1 → NP_001157515.1 MAP kinase-activated protein kinase 5 isoform 1

Status: VALIDATED

Source sequence(s)

AI715466, BC099161, FM032487

UniProtKB/TrEMBL

F1LN87

Related

ENSRNOP00000001817.6, ENSRNOT00000001817.9

Conserved Domains (2) summary

smart00220
Location:26 → 304

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14171
Location:15 → 304

STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

40654220..40673740

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089701.2 → XP_038945629.1 MAP kinase-activated protein kinase 5 isoform X5

UniProtKB/TrEMBL

F1LN87

Conserved Domains (1) summary

cd14171
Location:15 → 304

STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5
XM_063271588.1 → XP_063127658.1 MAP kinase-activated protein kinase 5 isoform X6
XM_063271585.1 → XP_063127655.1 MAP kinase-activated protein kinase 5 isoform X2
XM_039089703.2 → XP_038945631.1 MAP kinase-activated protein kinase 5 isoform X1

UniProtKB/TrEMBL

F7FFP2, Q4KLJ9

Related

ENSRNOP00000061902.3, ENSRNOT00000065314.4

Conserved Domains (1) summary

cl21453
Location:13 → 155

PKc_like; Protein Kinases, catalytic domain
XM_039089704.2 → XP_038945632.1 MAP kinase-activated protein kinase 5 isoform X3

Conserved Domains (1) summary

cl21453
Location:1 → 124

PKc_like; Protein Kinases, catalytic domain
XM_063271587.1 → XP_063127657.1 MAP kinase-activated protein kinase 5 isoform X4
XM_063271586.1 → XP_063127656.1 MAP kinase-activated protein kinase 5 isoform X3