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    Dgke diacylglycerol kinase epsilon [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497978, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Dgkeprovided by RGD
    Official Full Name
    diacylglycerol kinase epsilonprovided by RGD
    Primary source
    RGD:1560914
    See related
    EnsemblRapid:ENSRNOG00000002338 AllianceGenome:RGD:1560914
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP-dependent diacylglycerol kinase activity. Predicted to be involved in several processes, including glycerolipid metabolic process; lipid phosphorylation; and modulation of chemical synaptic transmission. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in glutamatergic synapse and membrane. Human ortholog(s) of this gene implicated in nephrotic syndrome type 7. Orthologous to human DGKE (diacylglycerol kinase epsilon). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Brain (RPKM 68.5), Heart (RPKM 58.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dgke in Genome Data Viewer
    Location:
    10q26
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (74348931..74374509, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (73853030..73877334, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (76375981..76408224, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene coilin Neighboring gene tripartite motif-containing 25 Neighboring gene uncharacterized LOC120095172 Neighboring gene similar to human chromosome 17 open reading frame 67 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene uncharacterized LOC134480709

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Diacylglycerol kinase ε localizes to subsurface cisterns of cerebellar Purkinje cells. Hozumi Y, et al. Cell Tissue Res, 2017 Jun. PMID 28191598
    2. Localization of diacylglycerol kinase epsilon on stress fibers in vascular smooth muscle cells. Nakano T, et al. Cell Tissue Res, 2009 Jul. PMID 19421779
    3. Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome. Lemaire M, et al. Nat Genet, 2013 May. PMID 23542698, Free PMC Article
    4. Substrate specificity of diacylglycerol kinase-epsilon and the phosphatidylinositol cycle. Shulga YV, et al. FEBS Lett, 2011 Dec 15. PMID 22108654, Free PMC Article
    5. Diacylglycerol kinase-epsilon restores cardiac dysfunction under chronic pressure overload: a new specific regulator of Galpha(q) signaling cascade. Niizeki T, et al. Am J Physiol Heart Circ Physiol, 2008 Jul. PMID 18487437

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings suggest that DGKepsilon plays an important role in neuronal and brain functions through its distinct neuronal expression and subcellular localization and also through coordinated arrangement with other molecules involving the phosphoinositide signaling pathway
      Title: Diacylglycerol kinase ε localizes to subsurface cisterns of cerebellar Purkinje cells.
    2. The DGKepsilon is evident in the outer limiting membrane.
      Title: Distinct expression and localization of diacylglycerol kinase isozymes in rat retina.
    3. Diacylglycerol kinase-epsilon restores cardiac dysfunction under chronic pressure overload: a new specific regulator of Galpha(q) signaling cascade.
      Title: Diacylglycerol kinase-epsilon restores cardiac dysfunction under chronic pressure overload: a new specific regulator of Galpha(q) signaling cascade.
    4. DGKepsilon interacts with actin stress fibers and is involved in their stability in vascular smooth muscle cells.
      Title: Localization of diacylglycerol kinase epsilon on stress fibers in vascular smooth muscle cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124991

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in diacylglycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycerolipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    diacylglycerol kinase epsilon
    Names
    diacylglycerol kinase, epsilon 64kDa
    NP_001381287.1
    NP_001381288.1
    XP_063125724.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394358.2 → NP_001381287.1  diacylglycerol kinase epsilon isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A096UWG9
      Related
      ENSRNOP00000003179.4, ENSRNOT00000003179.7
      Conserved Domains (4) summary
      smart00045
      Location:367 → 524
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:219 → 347
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd20801
      Location:55 → 108
      C1_DGKepsilon_typeIII_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type III diacylglycerol kinase, DAG kinase epsilon, and similar proteins
      cd20853
      Location:123 → 187
      C1_DGKepsilon_typeIII_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type III diacylglycerol kinase, DAG kinase epsilon, and similar proteins

    2. NM_001394359.2 → NP_001381288.1  diacylglycerol kinase epsilon isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      Related
      ENSRNOP00000100575.1, ENSRNOT00000142774.1
      Conserved Domains (4) summary
      smart00046
      Location:219 → 347
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd20801
      Location:55 → 108
      C1_DGKepsilon_typeIII_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type III diacylglycerol kinase, DAG kinase epsilon, and similar proteins
      cd20853
      Location:123 → 187
      C1_DGKepsilon_typeIII_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type III diacylglycerol kinase, DAG kinase epsilon, and similar proteins
      cl02440
      Location:367 → 500
      DAGK_acc; Diacylglycerol kinase accessory domain

    RNA

    1. NR_172101.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      74348931..74374509 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269654.1 → XP_063125724.1  diacylglycerol kinase epsilon isoform X1

      Related
      ENSRNOP00000104844.1, ENSRNOT00000165330.1

    RNA

    1. XR_005489925.2 RNA Sequence

    2. XR_005489926.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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