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    Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497931, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pik3r5provided by RGD
    Official Full Name
    phosphoinositide-3-kinase, regulatory subunit 5provided by RGD
    Primary source
    RGD:1563261
    See related
    EnsemblRapid:ENSRNOG00000023428 AllianceGenome:RGD:1563261
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563261
    Summary
    Enables 1-phosphatidylinositol-3-kinase regulator activity. Involved in phosphatidylinositol metabolic process. Part of phosphatidylinositol 3-kinase complex. Human ortholog(s) of this gene implicated in ataxia with oculomotor apraxia type 3 and colon cancer. Orthologous to human PIK3R5 (phosphoinositide-3-kinase regulatory subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 55.1), Thymus (RPKM 53.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pik3r5 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (53631469..53699550)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (53132585..53200663)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (55013686..55078986)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene syntaxin 8 Neighboring gene uncharacterized LOC134480811 Neighboring gene netrin 1 Neighboring gene phosphoinositide-3-kinase, regulatory subunit 5 like 1 Neighboring gene transfer RNA threonine (anticodon UGU) 2 Neighboring gene phosphoinositide-3-kinase, regulatory subunit 6 Neighboring gene major facilitator superfamily domain containing 6-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Chromatin immunoprecipitation microarrays for identification of genes silenced by histone H3 lysine 9 methylation. Kondo Y, et al. Proc Natl Acad Sci U S A, 2004 May 11. PMID 15123805, Free PMC Article
    2. Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase gamma. Voigt P, et al. J Biol Chem, 2005 Feb 11. PMID 15611065
    3. Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor. Kaplan-Albuquerque N, et al. J Biol Chem, 2003 Oct 10. PMID 12882977
    4. Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma. Brock C, et al. J Cell Biol, 2003 Jan 6. PMID 12507995, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol-3-kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-phosphatidylinositol-3-kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex, class IA ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class IB IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class IB ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphoinositide 3-kinase regulatory subunit 5
    Names
    phosphoinositide-3-kinase, regulatory subunit 5, p101

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191923.1 → NP_001178852.1  phosphoinositide 3-kinase regulatory subunit 5

      See identical proteins and their annotated locations for NP_001178852.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HFK4, D4A4I3
      Conserved Domains (1) summary
      pfam10486
      Location:6 → 872
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      53631469..53699550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246770.5 → XP_006246832.1  phosphoinositide 3-kinase regulatory subunit 5 isoform X1

      See identical proteins and their annotated locations for XP_006246832.1

      UniProtKB/TrEMBL
      A6HFK4, D4A4I3
      Related
      ENSRNOP00000030578.3, ENSRNOT00000032785.7
      Conserved Domains (1) summary
      pfam10486
      Location:6 → 872
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

    2. XM_017597454.3 → XP_017452943.1  phosphoinositide 3-kinase regulatory subunit 5 isoform X2

      UniProtKB/TrEMBL
      A6HFK4

    3. XM_039086573.2 → XP_038942501.1  phosphoinositide 3-kinase regulatory subunit 5 isoform X1

      UniProtKB/TrEMBL
      A6HFK4, D4A4I3
      Conserved Domains (1) summary
      pfam10486
      Location:6 → 872
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

    4. XM_063269619.1 → XP_063125689.1  phosphoinositide 3-kinase regulatory subunit 5 isoform X1

      UniProtKB/TrEMBL
      D4A4I3

    5. XM_063269618.1 → XP_063125688.1  phosphoinositide 3-kinase regulatory subunit 5 isoform X1

      UniProtKB/TrEMBL
      D4A4I3
    Nucleotide Protein Strain
    Heading Accession and Version

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