GRIN2B glutamate ionotropic receptor NMDA type subunit 2B [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: GRIN2Bprovided by VGNC
Official Full Name: glutamate ionotropic receptor NMDA type subunit 2Bprovided by VGNC
Primary source: VGNC:VGNC:41493
See related: Ensembl:ENSCAFG00845022981
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: GluN2B
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 27

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	27	NC_051831.1 (32702956..33191598)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	27	NC_006609.4 (13572169..13850223, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	27	NC_049248.1 (13302777..13581228, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	27	NC_049287.1 (32798882..33078120)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	27	NC_049768.1 (32748401..33027217)

Chromosome 27 - NC_051831.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

GRIN2B (e-PCR)
- UniSTS:264044

C27.671 (e-PCR)
- UniSTS:262827

D12S1627 (e-PCR), detects polymorphism
- UniSTS:61885

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables NMDA glutamate receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info	PubMed
involved_in long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of NMDA selective glutamate receptor complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: glutamate receptor ionotropic, NMDA 2B

Names: N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 2B; NMDAR2B; NR2B; glutamate [NMDA] receptor subunit epsilon-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008719.1 → NP_001008719.1 glutamate receptor ionotropic, NMDA 2B precursor

See identical proteins and their annotated locations for NP_001008719.1

Status: PROVISIONAL

Source sequence(s)

AB195992

UniProtKB/Swiss-Prot

Q5R1P3

UniProtKB/TrEMBL

A0A8I3PHQ5

Related

ENSCAFP00845031842.1, ENSCAFT00845040679.1

Conserved Domains (3) summary

cd13718
Location:403 → 803

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:33 → 388

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:840 → 1485

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051831.1 Reference ROS_Cfam_1.0

Range

32702956..33191598

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038437816.1 → XP_038293744.1 glutamate receptor ionotropic, NMDA 2B isoform X1

UniProtKB/TrEMBL

A0A8I3PHQ5

Conserved Domains (3) summary

cd13718
Location:439 → 839

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:41 → 424

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:876 → 1521

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_038437811.1 → XP_038293739.1 glutamate receptor ionotropic, NMDA 2B isoform X1

UniProtKB/TrEMBL

A0A8I3PHQ5

Conserved Domains (3) summary

cd13718
Location:439 → 839

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:41 → 424

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:876 → 1521

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_038437813.1 → XP_038293741.1 glutamate receptor ionotropic, NMDA 2B isoform X1

UniProtKB/TrEMBL

A0A8I3PHQ5

Conserved Domains (3) summary

cd13718
Location:439 → 839

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:41 → 424

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:876 → 1521

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_038437810.1 → XP_038293738.1 glutamate receptor ionotropic, NMDA 2B isoform X1

UniProtKB/TrEMBL

A0A8I3PHQ5

Conserved Domains (3) summary

cd13718
Location:439 → 839

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:41 → 424

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:876 → 1521

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_038437812.1 → XP_038293740.1 glutamate receptor ionotropic, NMDA 2B isoform X1

UniProtKB/TrEMBL

A0A8I3PHQ5

Conserved Domains (3) summary

cd13718
Location:439 → 839

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:41 → 424

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:876 → 1521

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_038437814.1 → XP_038293742.1 glutamate receptor ionotropic, NMDA 2B isoform X1

UniProtKB/TrEMBL

A0A8I3PHQ5

Conserved Domains (3) summary

cd13718
Location:439 → 839

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:41 → 424

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:876 → 1521

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_038437815.1 → XP_038293743.1 glutamate receptor ionotropic, NMDA 2B isoform X1

UniProtKB/TrEMBL

A0A8I3PHQ5

Conserved Domains (3) summary

cd13718
Location:439 → 839

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:41 → 424

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:876 → 1521

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_038437820.1 → XP_038293748.1 glutamate receptor ionotropic, NMDA 2B isoform X1

UniProtKB/TrEMBL

A0A8I3PHQ5

Conserved Domains (3) summary

cd13718
Location:439 → 839

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:41 → 424

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:876 → 1521

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_038437822.1 → XP_038293750.1 glutamate receptor ionotropic, NMDA 2B isoform X2

UniProtKB/TrEMBL

A0A8C0PUE4, A0A8I3PHQ5

Conserved Domains (3) summary

cd13718
Location:431 → 831

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:33 → 416

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:868 → 1513

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_038437823.1 → XP_038293751.1 glutamate receptor ionotropic, NMDA 2B isoform X3

UniProtKB/TrEMBL

A0A8I3PH93, A0A8I3PHQ5, A0A8P0TRH2

Related

ENSCAFP00845031759.1, ENSCAFT00845040573.1

Conserved Domains (3) summary

cd13718
Location:411 → 811

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:41 → 396

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:848 → 1493

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_038437818.1 → XP_038293746.1 glutamate receptor ionotropic, NMDA 2B isoform X1

UniProtKB/TrEMBL

A0A8I3PHQ5

Conserved Domains (3) summary

cd13718
Location:439 → 839

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:41 → 424

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:876 → 1521

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_038437819.1 → XP_038293747.1 glutamate receptor ionotropic, NMDA 2B isoform X1

UniProtKB/TrEMBL

A0A8I3PHQ5

Conserved Domains (3) summary

cd13718
Location:439 → 839

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:41 → 424

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:876 → 1521

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_038437821.1 → XP_038293749.1 glutamate receptor ionotropic, NMDA 2B isoform X1

UniProtKB/TrEMBL

A0A8I3PHQ5

Conserved Domains (3) summary

cd13718
Location:439 → 839

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:41 → 424

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:876 → 1521

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_038437817.1 → XP_038293745.1 glutamate receptor ionotropic, NMDA 2B isoform X1

UniProtKB/TrEMBL

A0A8I3PHQ5

Conserved Domains (3) summary

cd13718
Location:439 → 839

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:41 → 424

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:876 → 1521

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_038437824.1 → XP_038293752.1 glutamate receptor ionotropic, NMDA 2B isoform X4

UniProtKB/TrEMBL

A0A8C0Z584, A0A8I3PHQ5

Conserved Domains (3) summary

cd13718
Location:290 → 690

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam10565
Location:727 → 1372

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

cl10011
Location:1 → 275

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
XM_038437825.1 → XP_038293753.1 glutamate receptor ionotropic, NMDA 2B isoform X4

UniProtKB/TrEMBL

A0A8C0Z584, A0A8I3PHQ5

Conserved Domains (3) summary

cd13718
Location:290 → 690

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam10565
Location:727 → 1372

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

cl10011
Location:1 → 275

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily