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    def8 differentially expressed in FDCP 8 homolog [ Danio rerio (zebrafish) ]

    Gene ID: 492523, updated on 19-Jun-2024

    Summary

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    Official Symbol
    def8provided by ZNC
    Official Full Name
    differentially expressed in FDCP 8 homologprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041114-96
    See related
    Ensembl:ENSDARG00000068208 AllianceGenome:ZFIN:ZDB-GENE-041114-96
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:101815
    Summary
    Predicted to act upstream of or within intracellular signal transduction. Orthologous to human DEF8 (differentially expressed in FDCP 8 homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See def8 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (31280973..31459498)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (31302652..31481108)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene transcription factor 25 (basic helix-loop-helix) Neighboring gene melanocortin 1 receptor Neighboring gene uncharacterized LOC101886860 Neighboring gene uncharacterized LOC101884990 Neighboring gene uncharacterized LOC110438123

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    differentially expressed in FDCP 8 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328206.1 → NP_001315135.1  differentially expressed in FDCP 8 homolog

      Status: VALIDATED

      Source sequence(s)
      CABZ01036947, CABZ01036951, CABZ01036952, CR457484, CU570686, CU570893, LO018675
      UniProtKB/TrEMBL
      A0A0R4IHS8, A0A8M1P9P0
      Related
      ENSDARP00000132751.1, ENSDART00000170285.2
      Conserved Domains (2) summary
      pfam13901
      Location:228 → 401
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl00040
      Location:133 → 183
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      31280973..31459498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009293651.2 → XP_009291926.1  differentially expressed in FDCP 8 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8M3AJN0
      Conserved Domains (2) summary
      cd00029
      Location:133 → 183
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam13901
      Location:228 → 301
      zf-RING_9; Putative zinc-RING and/or ribbon

    2. XM_021467639.1 → XP_021323314.1  differentially expressed in FDCP 8 homolog isoform X2

      UniProtKB/TrEMBL
      A0A8M9PFE2
      Related
      ENSDARP00000131683.1, ENSDART00000159720.2
      Conserved Domains (2) summary
      cl00040
      Location:133 → 183
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam13901
      Location:230 → 263
      zf-RING_9; Putative zinc-RING and/or ribbon

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001007395.1: Suppressed sequence

      Description
      NM_001007395.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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