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    SOX3 SRY-box transcription factor 3 [ Canis lupus familiaris (dog) ]

    Gene ID: 492178, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SOX3provided by VGNC
    Official Full Name
    SRY-box transcription factor 3provided by VGNC
    Primary source
    VGNC:VGNC:46679
    See related
    Ensembl:ENSCAFG00845030422
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See SOX3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) X NC_051843.1 (112345866..112347975, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) X NC_006621.4 (96180957..96183063, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) X NC_049260.1 (111344119..111346231, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) X NC_049299.1 (109479743..109481849, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) X NC_049780.1 (111665269..111667378, complement)

    Chromosome X - NC_051843.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102156336 Neighboring gene HUWE1 associated protein modifying stress responses 2 Neighboring gene spermatid nuclear transition protein 4-like Neighboring gene transfer RNA lysine (anticodon CUU) Neighboring gene nucleoside diphosphate kinase, mitochondrial-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Methylation Patterns of SOX3, SOX9, and WNT4 Genes in Gonads of Dogs with XX (SRY-Negative) Disorder of Sexual Development. Salamon S, et al. Sex Dev, 2017. PMID 28365713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The aim of this study was comparative methylation analysis of CpG islands in promoters of candidate genes for XX DSD: SOX9, SOX3, and WNT4.
      Title: Methylation Patterns of SOX3, SOX9, and WNT4 Genes in Gonads of Dogs with XX (SRY-Negative) Disorder of Sexual Development.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor SOX-3
    Names
    SRY-box 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051843.1 Reference ROS_Cfam_1.0

      Range
      112345866..112347975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038449094.1 → XP_038305022.1  transcription factor SOX-3

      UniProtKB/TrEMBL
      A0A8C0LG18, A0A8C0N1N6, A0A8I3Q427
      Related
      ENSCAFP00845042400.1, ENSCAFT00845053968.1
      Conserved Domains (2) summary
      cd01388
      Location:138 → 209
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam12336
      Location:208 → 301
      SOXp; SOX transcription factor

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049299.1 Alternate UMICH_Zoey_3.1

      Range
      109479743..109481849 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038525061.1 → XP_038380989.1  transcription factor SOX-3

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049780.1 Alternate UNSW_CanFamBas_1.0

      Range
      111665269..111667378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038651055.1 → XP_038506983.1  transcription factor SOX-3

      Conserved Domains (2) summary
      cd01388
      Location:138 → 209
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam12336
      Location:208 → 301
      SOXp; SOX transcription factor

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049260.1 Alternate UU_Cfam_GSD_1.0

      Range
      111344119..111346231 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038586623.1 → XP_038442551.1  transcription factor SOX-3

      UniProtKB/TrEMBL
      A0A8C0LG18, A0A8C0N1N6, A0A8I3Q427
      Conserved Domains (2) summary
      cd01388
      Location:138 → 209
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam12336
      Location:208 → 301
      SOXp; SOX transcription factor

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006621.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      96180957..96183063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_847841.5 → XP_852934.1  transcription factor SOX-3

      UniProtKB/TrEMBL
      A0A8C0N1N6, A0A8C0SIP7, A0A8P0SND0
      Conserved Domains (2) summary
      cd01388
      Location:138 → 209
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam12336
      Location:208 → 301
      SOXp; SOX transcription factor
    Nucleotide Protein
    Heading Accession and Version

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