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    TFE3 transcription factor binding to IGHM enhancer 3 [ Canis lupus familiaris (dog) ]

    Gene ID: 491872, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TFE3provided by VGNC
    Official Full Name
    transcription factor binding to IGHM enhancer 3provided by VGNC
    Primary source
    VGNC:VGNC:47293
    See related
    Ensembl:ENSCAFG00845031022
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See TFE3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) X NC_051843.1 (42317881..42328931, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) X NC_006621.4 (16557254..16568302, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) X NC_049260.1 (42386591..42397641, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) X NC_049299.1 (42304191..42315238, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) X NC_049780.1 (42291847..42302895, complement)

    Chromosome X - NC_051843.1Genomic Context describing neighboring genes Neighboring gene GRIP1 associated protein 1 Neighboring gene 60S ribosomal protein L17-like Neighboring gene coiled-coil domain containing 120 Neighboring gene PRA1 domain family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide identification and analysis of basic helix-loop-helix domains in dog, Canis lupus familiaris. Wang XH, et al. Mol Genet Genomics, 2015 Apr. PMID 25403511
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in humoral immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of osteoclast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor E3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051843.1 Reference ROS_Cfam_1.0

      Range
      42317881..42328931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038449977.1 → XP_038305905.1  transcription factor E3 isoform X1

      UniProtKB/TrEMBL
      A0A8C0R4K7, A0A8C0S7Y9, A0A8I3S7X7
      Related
      ENSCAFP00845043370.1, ENSCAFT00845055150.1
      Conserved Domains (3) summary
      cd18928
      Location:334 → 424
      bHLHzip_TFE3; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins
      pfam11851
      Location:429 → 569
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:110 → 263
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    2. XM_038449978.1 → XP_038305906.1  transcription factor E3 isoform X2

      Conserved Domains (3) summary
      cd18928
      Location:232 → 322
      bHLHzip_TFE3; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins
      pfam11851
      Location:327 → 467
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:8 → 161
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049299.1 Alternate UMICH_Zoey_3.1

      Range
      42304191..42315238 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038523426.1 → XP_038379354.1  transcription factor E3 isoform X1

      Conserved Domains (3) summary
      cd18928
      Location:334 → 424
      bHLHzip_TFE3; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins
      pfam11851
      Location:429 → 569
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:110 → 263
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    2. XM_038523427.1 → XP_038379355.1  transcription factor E3 isoform X2

      Conserved Domains (3) summary
      cd18928
      Location:232 → 322
      bHLHzip_TFE3; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins
      pfam11851
      Location:327 → 467
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:8 → 161
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049780.1 Alternate UNSW_CanFamBas_1.0

      Range
      42291847..42302895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038651908.1 → XP_038507836.1  transcription factor E3 isoform X1

      Conserved Domains (3) summary
      cd18928
      Location:334 → 424
      bHLHzip_TFE3; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins
      pfam11851
      Location:429 → 569
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:110 → 263
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    2. XM_038651909.1 → XP_038507837.1  transcription factor E3 isoform X2

      Conserved Domains (3) summary
      cd18928
      Location:232 → 322
      bHLHzip_TFE3; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins
      pfam11851
      Location:327 → 467
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:8 → 161
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049260.1 Alternate UU_Cfam_GSD_1.0

      Range
      42386591..42397641 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038587397.1 → XP_038443325.1  transcription factor E3 isoform X1

      UniProtKB/TrEMBL
      A0A8C0R4K7, A0A8C0S7Y9, A0A8I3S7X7
      Conserved Domains (3) summary
      cd18928
      Location:334 → 424
      bHLHzip_TFE3; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins
      pfam11851
      Location:429 → 569
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:110 → 263
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    2. XM_038587398.1 → XP_038443326.1  transcription factor E3 isoform X2

      Conserved Domains (3) summary
      cd18928
      Location:232 → 322
      bHLHzip_TFE3; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins
      pfam11851
      Location:327 → 467
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:8 → 161
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006621.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      16557254..16568302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_846254.6 → XP_851347.1  transcription factor E3 isoform X1

      UniProtKB/TrEMBL
      A0A8C0R4K7, A0A8C0S7Y9, A0A8I3S7X7
      Conserved Domains (3) summary
      cd18928
      Location:334 → 424
      bHLHzip_TFE3; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins
      pfam11851
      Location:429 → 569
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:110 → 263
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    2. XM_014111858.3 → XP_013967333.1  transcription factor E3 isoform X2

      Conserved Domains (3) summary
      cd18928
      Location:232 → 322
      bHLHzip_TFE3; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins
      pfam11851
      Location:327 → 467
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:8 → 161
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
    Nucleotide Protein
    Heading Accession and Version

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