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    CYBB cytochrome b-245 beta chain [ Canis lupus familiaris (dog) ]

    Gene ID: 491825, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CYBBprovided by VGNC
    Official Full Name
    cytochrome b-245 beta chainprovided by VGNC
    Primary source
    VGNC:VGNC:50285
    See related
    Ensembl:ENSCAFG00845023727
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    NOX2
    Orthologs
    human mouse all
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    Genomic context

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    See CYBB in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) X NC_051843.1 (32578634..32613434)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) X NC_006621.4 (19880947..19915729)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) X NC_049260.1 (32671823..32706767)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) X NC_049299.1 (32660059..32694839)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) X NC_049780.1 (32623867..32658828)

    Chromosome X - NC_051843.1Genomic Context describing neighboring genes Neighboring gene LanC like family member 3 Neighboring gene X-linked Kx blood group antigen, Kell and VPS13A binding protein Neighboring gene glutamine synthetase-like Neighboring gene dynein light chain Tctex-type 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Attenuation of Oxidative Injury With Targeted Expression of NADPH Oxidase 2 Short Hairpin RNA Prevents Onset and Maintenance of Electrical Remodeling in the Canine Atrium: A Novel Gene Therapy Approach to Atrial Fibrillation. Yoo S, et al. Circulation, 2020 Sep 29. PMID 32686471, Free PMC Article
    2. NADPH oxidase contributes to coronary endothelial dysfunction in the failing heart. Zhang P, et al. Am J Physiol Heart Circ Physiol, 2009 Mar. PMID 19168727, Free PMC Article
    3. Ensembl 2006. Birney E, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381931, Free PMC Article
    4. Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox/Duox) family of enzymes. Kawahara T, et al. BMC Evol Biol, 2007 Jul 6. PMID 17612411, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Attenuation of Oxidative Injury With Targeted Expression of NADPH Oxidase 2 Short Hairpin RNA Prevents Onset and Maintenance of Electrical Remodeling in the Canine Atrium: A Novel Gene Therapy Approach to Atrial Fibrillation.
      Title: Attenuation of Oxidative Injury With Targeted Expression of NADPH Oxidase 2 Short Hairpin RNA Prevents Onset and Maintenance of Electrical Remodeling in the Canine Atrium: A Novel Gene Therapy Approach to Atrial Fibrillation.
    2. NADPH oxidase subunit Nox2 contributes to coronary endothelial dysfunction in the failing heart.
      Title: NADPH oxidase contributes to coronary endothelial dysfunction in the failing heart.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables superoxide-generating NAD(P)H oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NADPH oxidase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome b-245, beta polypeptide
    Names
    cytochrome b-245, beta polypeptide (chronic granulomatous disease)
    predicted NADPH oxidase-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100291.1 → NP_001093761.1  cytochrome b-245, beta polypeptide

      See identical proteins and their annotated locations for NP_001093761.1

      Status: PROVISIONAL

      Source sequence(s)
      BR000269
      UniProtKB/TrEMBL
      A0A8C0K7S5, A0A8C0MXX3, A0A8C0SUZ1, A7E3K7
      Related
      ENSCAFP00845032921.1, ENSCAFT00845041976.1
      Conserved Domains (3) summary
      cd06186
      Location:297 → 570
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      pfam01794
      Location:59 → 219
      Ferric_reduct; Ferric reductase like transmembrane component
      cl26813
      Location:165 → 423
      PLN02844; oxidoreductase/ferric-chelate reductase

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051843.1 Reference ROS_Cfam_1.0

      Range
      32578634..32613434
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049299.1 Alternate UMICH_Zoey_3.1

      Range
      32660059..32694839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049780.1 Alternate UNSW_CanFamBas_1.0

      Range
      32623867..32658828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049260.1 Alternate UU_Cfam_GSD_1.0

      Range
      32671823..32706767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006621.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      19880947..19915729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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