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    PLK1 polo like kinase 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 489971, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PLK1provided by VGNC
    Official Full Name
    polo like kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:44695
    See related
    Ensembl:ENSCAFG00845001570
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See PLK1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (22309120..22320926, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (23732161..23743926, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (22410301..22422125, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (22112754..22124540, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (22014857..22026662, complement)

    Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene collagen alpha-1(I) chain-like Neighboring gene calcineurin like EF-hand protein 2 Neighboring gene endoplasmic reticulum to nucleus signaling 2 Neighboring gene uncharacterized LOC111096276 Neighboring gene dynactin subunit 5 Neighboring gene partner and localizer of BRCA2 Neighboring gene uncharacterized LOC111096275

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mitotic regulator polo-like kinase 1 as a potential therapeutic target for c-Myc-overexpressing canine osteosarcomas. Gola C, et al. Vet Comp Oncol, 2022 Dec. PMID 36054794, Free PMC Article
    2. Polo-like kinase 1-mediated phosphorylation of the GTP-binding protein Ran is important for bipolar spindle formation. Feng Y, et al. Biochem Biophys Res Commun, 2006 Oct 13. PMID 16930555
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The mitotic regulator polo-like kinase 1 as a potential therapeutic target for c-Myc-overexpressing canine osteosarcomas.
      Title: The mitotic regulator polo-like kinase 1 as a potential therapeutic target for c-Myc-overexpressing canine osteosarcomas.
    2. Plk1 regulates the spindle organization partially through its phosphorylation on Ran
      Title: Polo-like kinase 1-mediated phosphorylation of the GTP-binding protein Ran is important for bipolar spindle formation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PLK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase PLK1
    XP_038334710.1
    XP_038395957.1
    XP_038460040.1
    XP_038524758.1
    XP_547091.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051810.1 Reference ROS_Cfam_1.0

      Range
      22309120..22320926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038668830.1 → XP_038524758.1  serine/threonine-protein kinase PLK1

      UniProtKB/TrEMBL
      A0A8C0L716, A0A8C0NVZ0, A0A8I3MIN2
      Related
      ENSCAFP00845002140.1, ENSCAFT00845002704.1
      Conserved Domains (3) summary
      cd13117
      Location:509 → 590
      POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd13118
      Location:407 → 494
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cl21453
      Location:45 → 309
      PKc_like; Protein Kinases, catalytic domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049266.1 Alternate UMICH_Zoey_3.1

      Range
      22112754..22124540 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038478782.1 → XP_038334710.1  serine/threonine-protein kinase PLK1

      Conserved Domains (3) summary
      cd13117
      Location:509 → 590
      POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd13118
      Location:407 → 494
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cl21453
      Location:45 → 309
      PKc_like; Protein Kinases, catalytic domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

      Range
      22014857..22026662 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038604112.1 → XP_038460040.1  serine/threonine-protein kinase PLK1

      Conserved Domains (3) summary
      cd13117
      Location:509 → 590
      POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd13118
      Location:407 → 494
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cl21453
      Location:45 → 309
      PKc_like; Protein Kinases, catalytic domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

      Range
      22410301..22422125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038540029.1 → XP_038395957.1  LOW QUALITY PROTEIN: serine/threonine-protein kinase PLK1

      UniProtKB/TrEMBL
      A0A8C0L716, A0A8C0NVZ0, A0A8I3MIN2
      Conserved Domains (3) summary
      cd13117
      Location:509 → 590
      POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd13118
      Location:407 → 494
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cl21453
      Location:45 → 309
      PKc_like; Protein Kinases, catalytic domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      23732161..23743926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_547091.7 → XP_547091.3  serine/threonine-protein kinase PLK1

      UniProtKB/TrEMBL
      A0A8C0L716, A0A8C0NVZ0, A0A8I3MIN2
      Conserved Domains (3) summary
      cd13117
      Location:509 → 590
      POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd13118
      Location:407 → 494
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cl21453
      Location:45 → 309
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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