U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    ITGAM integrin subunit alpha M [ Canis lupus familiaris (dog) ]

    Gene ID: 489928, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ITGAMprovided by VGNC
    Official Full Name
    integrin subunit alpha Mprovided by VGNC
    Primary source
    VGNC:VGNC:42133
    See related
    Ensembl:ENSCAFG00845011550
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ITGAM in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (17068771..17127224, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (18516000..18571559, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (17102490..17158038, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (16871848..16927654, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (16791010..16846822, complement)

    Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene integrin alpha-D-like Neighboring gene integrin subunit alpha X Neighboring gene ubiquitin-conjugating enzyme E2 C-like Neighboring gene prefoldin subunit 4-like Neighboring gene uncharacterized LOC119872173 Neighboring gene uncharacterized LOC119872172 Neighboring gene ORM1-like protein 2 Neighboring gene tripartite motif containing 72

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of integrin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    integrin alpha-M

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051810.1 Reference ROS_Cfam_1.0

      Range
      17068771..17127224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038668539.1 → XP_038524467.1  integrin alpha-M isoform X3

      UniProtKB/TrEMBL
      A0A8C0L2J8, A0A8I3NIY0
      Related
      ENSCAFP00845016364.1, ENSCAFT00845020843.1
      Conserved Domains (4) summary
      smart00191
      Location:517 → 572
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:150 → 325
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:1059 → 1073
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:615 → 1033
      Integrin_alpha2; Integrin alpha

    2. XM_038668538.1 → XP_038524466.1  integrin alpha-M isoform X2

      UniProtKB/TrEMBL
      A0A8C0L2J8, A0A8I3NJF7
      Related
      ENSCAFP00845016275.1, ENSCAFT00845020748.1
      Conserved Domains (4) summary
      smart00191
      Location:517 → 572
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:150 → 325
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:1094 → 1107
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:615 → 1033
      Integrin_alpha2; Integrin alpha

    3. XM_038668537.1 → XP_038524465.1  integrin alpha-M isoform X1

      UniProtKB/TrEMBL
      A0A8C0L2J8, A0A8C0M9J9, A0A8I3NV00
      Related
      ENSCAFP00845016081.1, ENSCAFT00845020510.1
      Conserved Domains (4) summary
      smart00191
      Location:517 → 572
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:150 → 325
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:1130 → 1144
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:615 → 1033
      Integrin_alpha2; Integrin alpha

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049266.1 Alternate UMICH_Zoey_3.1

      Range
      16871848..16927654 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038478481.1 → XP_038334409.1  integrin alpha-M isoform X3

      Conserved Domains (4) summary
      smart00191
      Location:517 → 572
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:150 → 325
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:1059 → 1073
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:615 → 1033
      Integrin_alpha2; Integrin alpha

    2. XM_038478480.1 → XP_038334408.1  integrin alpha-M isoform X2

      Conserved Domains (4) summary
      smart00191
      Location:517 → 572
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:150 → 325
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:1094 → 1107
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:615 → 1033
      Integrin_alpha2; Integrin alpha

    3. XM_038478479.1 → XP_038334407.1  integrin alpha-M isoform X1

      Conserved Domains (4) summary
      smart00191
      Location:517 → 572
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:150 → 325
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:1130 → 1144
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:615 → 1033
      Integrin_alpha2; Integrin alpha

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

      Range
      16791010..16846822 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038603821.1 → XP_038459749.1  integrin alpha-M isoform X3

      Conserved Domains (4) summary
      smart00191
      Location:517 → 572
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:150 → 325
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:1059 → 1073
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:615 → 1033
      Integrin_alpha2; Integrin alpha

    2. XM_038603820.1 → XP_038459748.1  integrin alpha-M isoform X2

      Conserved Domains (4) summary
      smart00191
      Location:517 → 572
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:150 → 325
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:1094 → 1107
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:615 → 1033
      Integrin_alpha2; Integrin alpha

    3. XM_038603819.1 → XP_038459747.1  integrin alpha-M isoform X1

      Conserved Domains (4) summary
      smart00191
      Location:517 → 572
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:150 → 325
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:1130 → 1144
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:615 → 1033
      Integrin_alpha2; Integrin alpha

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

      Range
      17102490..17158038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038539736.1 → XP_038395664.1  integrin alpha-M isoform X3

      UniProtKB/TrEMBL
      A0A8C0L2J8

    2. XM_038539735.1 → XP_038395663.1  integrin alpha-M isoform X2

      UniProtKB/TrEMBL
      A0A8C0L2J8

    3. XM_038539734.1 → XP_038395662.1  integrin alpha-M isoform X1

      UniProtKB/TrEMBL
      A0A8C0L2J8

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      18516000..18571559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014114360.3 → XP_013969835.1  integrin alpha-M isoform X3

      UniProtKB/TrEMBL
      A0A8C0L2J8, A0A8I3NIY0
      Conserved Domains (4) summary
      smart00191
      Location:517 → 572
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:150 → 325
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:1059 → 1073
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:615 → 1033
      Integrin_alpha2; Integrin alpha

    2. XM_038541967.1 → XP_038397895.1  integrin alpha-M isoform X2

      UniProtKB/TrEMBL
      A0A8C0L2J8, A0A8I3NJF7
      Conserved Domains (4) summary
      smart00191
      Location:517 → 572
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:150 → 325
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:1094 → 1107
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:615 → 1033
      Integrin_alpha2; Integrin alpha

    3. XM_005621235.4 → XP_005621292.1  integrin alpha-M isoform X1

      See identical proteins and their annotated locations for XP_005621292.1

      UniProtKB/TrEMBL
      A0A8C0L2J8, A0A8C0M9J9, A0A8I3NV00
      Conserved Domains (4) summary
      smart00191
      Location:517 → 572
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:150 → 325
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:1130 → 1144
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:615 → 1033
      Integrin_alpha2; Integrin alpha
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.