ITGAL integrin subunit alpha L [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: ITGALprovided by VGNC
Official Full Name: integrin subunit alpha Lprovided by VGNC
Primary source: VGNC:VGNC:42132
See related: Ensembl:ENSCAFG00845013917
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	6	NC_051810.1 (17735141..17775970, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	6	NC_006588.4 (19178232..19219073, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	6	NC_049227.1 (17765852..17806699, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	6	NC_049266.1 (17535332..17576226, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	6	NC_049747.1 (17450788..17491710, complement)

Chromosome 6 - NC_051810.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Selective CD11a upregulation on neutrophils in the acute phase of steroid-responsive meningitis-arteritis in dogs.
Title: Selective CD11a upregulation on neutrophils in the acute phase of steroid-responsive meningitis-arteritis in dogs.

Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables integrin binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of integrin complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: integrin alpha-L

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051810.1 Reference ROS_Cfam_1.0

Range

17735141..17775970 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038668615.1 → XP_038524543.1 integrin alpha-L isoform X2

UniProtKB/TrEMBL

A0A8C0LYN0

Conserved Domains (4) summary

smart00191
Location:421 → 473

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00357
Location:1017 → 1031

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:516 → 887

Integrin_alpha2; Integrin alpha

cl00057
Location:59 → 227

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_038668616.1 → XP_038524544.1 integrin alpha-L isoform X2

UniProtKB/TrEMBL

A0A8C0LYN0

Conserved Domains (4) summary

smart00191
Location:421 → 473

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00357
Location:1017 → 1031

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:516 → 887

Integrin_alpha2; Integrin alpha

cl00057
Location:59 → 227

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_038668614.1 → XP_038524542.1 integrin alpha-L isoform X1

UniProtKB/TrEMBL

A0A8C0LYN0, A0A8C0SJG3, A0A8I3NS51

Related

ENSCAFP00845019686.1, ENSCAFT00845025024.1

Conserved Domains (4) summary

smart00191
Location:515 → 567

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00357
Location:1111 → 1125

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:610 → 981

Integrin_alpha2; Integrin alpha

cl00057
Location:153 → 321

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

Alternate UMICH_Zoey_3.1

Genomic

NC_049266.1 Alternate UMICH_Zoey_3.1

Range

17535332..17576226 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038478561.1 → XP_038334489.1 integrin alpha-L isoform X2

Conserved Domains (4) summary

smart00191
Location:421 → 473

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00357
Location:1017 → 1031

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:516 → 887

Integrin_alpha2; Integrin alpha

cl00057
Location:59 → 227

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_038478562.1 → XP_038334490.1 integrin alpha-L isoform X2

Conserved Domains (4) summary

smart00191
Location:421 → 473

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00357
Location:1017 → 1031

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:516 → 887

Integrin_alpha2; Integrin alpha

cl00057
Location:59 → 227

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_038478560.1 → XP_038334488.1 integrin alpha-L isoform X1

Conserved Domains (4) summary

smart00191
Location:515 → 567

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00357
Location:1111 → 1125

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:610 → 981

Integrin_alpha2; Integrin alpha

cl00057
Location:153 → 321

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049747.1 Alternate UNSW_CanFamBas_1.0

Range

17450788..17491710 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038603890.1 → XP_038459818.1 integrin alpha-L isoform X2

Conserved Domains (4) summary

smart00191
Location:421 → 473

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00357
Location:1017 → 1031

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:516 → 887

Integrin_alpha2; Integrin alpha

cl00057
Location:59 → 227

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_038603891.1 → XP_038459819.1 integrin alpha-L isoform X2

Conserved Domains (4) summary

smart00191
Location:421 → 473

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00357
Location:1017 → 1031

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:516 → 887

Integrin_alpha2; Integrin alpha

cl00057
Location:59 → 227

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_038603889.1 → XP_038459817.1 integrin alpha-L isoform X1

Conserved Domains (4) summary

smart00191
Location:515 → 567

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00357
Location:1111 → 1125

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:610 → 981

Integrin_alpha2; Integrin alpha

cl00057
Location:153 → 321

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049227.1 Alternate UU_Cfam_GSD_1.0

Range

17765852..17806699 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038539810.1 → XP_038395738.1 integrin alpha-L isoform X2

UniProtKB/TrEMBL

A0A8C0LYN0

Conserved Domains (4) summary

smart00191
Location:421 → 473

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00357
Location:1017 → 1031

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:516 → 887

Integrin_alpha2; Integrin alpha

cl00057
Location:59 → 227

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_038539811.1 → XP_038395739.1 integrin alpha-L isoform X2

UniProtKB/TrEMBL

A0A8C0LYN0

Conserved Domains (4) summary

smart00191
Location:421 → 473

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00357
Location:1017 → 1031

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:516 → 887

Integrin_alpha2; Integrin alpha

cl00057
Location:59 → 227

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_038539809.1 → XP_038395737.1 integrin alpha-L isoform X1

UniProtKB/TrEMBL

A0A8C0LYN0, A0A8C0SJG3, A0A8I3NS51

Conserved Domains (4) summary

smart00191
Location:515 → 567

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00357
Location:1111 → 1125

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:610 → 981

Integrin_alpha2; Integrin alpha

cl00057
Location:153 → 321

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

19178232..19219073 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_022419856.2 → XP_022275564.1 integrin alpha-L isoform X2

UniProtKB/TrEMBL

A0A8C0LYN0

Conserved Domains (4) summary

smart00191
Location:421 → 473

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00357
Location:1017 → 1031

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:516 → 887

Integrin_alpha2; Integrin alpha

cl00057
Location:59 → 227

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_022419855.2 → XP_022275563.1 integrin alpha-L isoform X2

UniProtKB/TrEMBL

A0A8C0LYN0

Conserved Domains (4) summary

smart00191
Location:421 → 473

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00357
Location:1017 → 1031

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:516 → 887

Integrin_alpha2; Integrin alpha

cl00057
Location:59 → 227

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_547024.6 → XP_547024.2 integrin alpha-L isoform X1

UniProtKB/TrEMBL

A0A8C0LYN0, A0A8C0SJG3, A0A8I3NS51

Conserved Domains (4) summary

smart00191
Location:515 → 567

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00357
Location:1111 → 1125

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:610 → 981

Integrin_alpha2; Integrin alpha

cl00057
Location:153 → 321

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...