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    LIMK1 LIM domain kinase 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 489800, updated on 17-Aug-2024

    Summary

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    Official Symbol
    LIMK1provided by VGNC
    Official Full Name
    LIM domain kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:42681
    See related
    Ensembl:ENSCAFG00845002825
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See LIMK1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (6076858..6100527, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (7959877..7983548, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (6178780..6202457, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (6067274..6090947, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (6015097..6038762, complement)

    Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111096485 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC111096192 Neighboring gene 60S ribosomal protein L39-like Neighboring gene elastin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LIM domain kinase 1
    XP_038333764.1
    XP_038333765.1
    XP_038392703.1
    XP_038395012.1
    XP_038395013.1
    XP_038459103.1
    XP_038459104.1
    XP_038523809.1
    XP_038523810.1
    XP_849646.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051810.1 Reference ROS_Cfam_1.0

      Range
      6076858..6100527 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038667881.1 → XP_038523809.1  LIM domain kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KHF0, A0A8C0KHH4, A0A8I3RQZ5, A0A8P0NE76
      Related
      ENSCAFP00845004028.1, ENSCAFT00845005059.1
      Conserved Domains (4) summary
      cd09462
      Location:5 → 77
      LIM1_LIMK1; The first LIM domain of LIMK1 (LIM domain Kinase 1)
      cd09464
      Location:84 → 138
      LIM2_LIMK1; The second LIM domain of LIMK1 (LIM domain Kinase 1)
      cd14221
      Location:345 → 611
      STKc_LIMK1; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1
      pfam00595
      Location:165 → 255
      PDZ; PDZ domain (Also known as DHR or GLGF)

    2. XM_038667882.1 → XP_038523810.1  LIM domain kinase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0KE28, A0A8C0S6N8, A0A8I3MMK5
      Related
      ENSCAFP00845004000.1, ENSCAFT00845005017.1
      Conserved Domains (4) summary
      cd09464
      Location:51 → 105
      LIM2_LIMK1; The second LIM domain of LIMK1 (LIM domain Kinase 1)
      cd14221
      Location:312 → 578
      STKc_LIMK1; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1
      pfam00595
      Location:132 → 222
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl02475
      Location:18 → 44
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049266.1 Alternate UMICH_Zoey_3.1

      Range
      6067274..6090947 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038477836.1 → XP_038333764.1  LIM domain kinase 1 isoform X1

      Conserved Domains (4) summary
      cd09462
      Location:5 → 77
      LIM1_LIMK1; The first LIM domain of LIMK1 (LIM domain Kinase 1)
      cd09464
      Location:84 → 138
      LIM2_LIMK1; The second LIM domain of LIMK1 (LIM domain Kinase 1)
      cd14221
      Location:345 → 611
      STKc_LIMK1; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1
      pfam00595
      Location:165 → 255
      PDZ; PDZ domain (Also known as DHR or GLGF)

    2. XM_038477837.1 → XP_038333765.1  LIM domain kinase 1 isoform X2

      Conserved Domains (4) summary
      cd09464
      Location:51 → 105
      LIM2_LIMK1; The second LIM domain of LIMK1 (LIM domain Kinase 1)
      cd14221
      Location:312 → 578
      STKc_LIMK1; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1
      pfam00595
      Location:132 → 222
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl02475
      Location:18 → 44
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

      Range
      6015097..6038762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038603175.1 → XP_038459103.1  LIM domain kinase 1 isoform X1

      Conserved Domains (4) summary
      cd09462
      Location:5 → 77
      LIM1_LIMK1; The first LIM domain of LIMK1 (LIM domain Kinase 1)
      cd09464
      Location:84 → 138
      LIM2_LIMK1; The second LIM domain of LIMK1 (LIM domain Kinase 1)
      cd14221
      Location:345 → 611
      STKc_LIMK1; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1
      pfam00595
      Location:165 → 255
      PDZ; PDZ domain (Also known as DHR or GLGF)

    2. XM_038603176.1 → XP_038459104.1  LIM domain kinase 1 isoform X2

      Conserved Domains (4) summary
      cd09464
      Location:51 → 105
      LIM2_LIMK1; The second LIM domain of LIMK1 (LIM domain Kinase 1)
      cd14221
      Location:312 → 578
      STKc_LIMK1; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1
      pfam00595
      Location:132 → 222
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl02475
      Location:18 → 44
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

      Range
      6178780..6202457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038539084.1 → XP_038395012.1  LIM domain kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KHF0, A0A8C0KHH4, A0A8I3RQZ5, A0A8P0NE76
      Conserved Domains (4) summary
      cd09462
      Location:5 → 77
      LIM1_LIMK1; The first LIM domain of LIMK1 (LIM domain Kinase 1)
      cd09464
      Location:84 → 138
      LIM2_LIMK1; The second LIM domain of LIMK1 (LIM domain Kinase 1)
      cd14221
      Location:345 → 611
      STKc_LIMK1; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1
      pfam00595
      Location:165 → 255
      PDZ; PDZ domain (Also known as DHR or GLGF)

    2. XM_038539085.1 → XP_038395013.1  LIM domain kinase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0KE28

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      7959877..7983548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_844553.4 → XP_849646.2  LIM domain kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KHF0, A0A8C0KHH4, A0A8I3RQZ5, A0A8P0NE76
      Conserved Domains (4) summary
      cd09462
      Location:5 → 77
      LIM1_LIMK1; The first LIM domain of LIMK1 (LIM domain Kinase 1)
      cd09464
      Location:84 → 138
      LIM2_LIMK1; The second LIM domain of LIMK1 (LIM domain Kinase 1)
      cd14221
      Location:345 → 611
      STKc_LIMK1; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1
      pfam00595
      Location:165 → 255
      PDZ; PDZ domain (Also known as DHR or GLGF)

    2. XM_038536775.1 → XP_038392703.1  LIM domain kinase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0KE28, A0A8C0S6N8, A0A8I3MMK5
      Conserved Domains (4) summary
      cd09464
      Location:51 → 105
      LIM2_LIMK1; The second LIM domain of LIMK1 (LIM domain Kinase 1)
      cd14221
      Location:312 → 578
      STKc_LIMK1; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1
      pfam00595
      Location:132 → 222
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl02475
      Location:18 → 44
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    Nucleotide Protein
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