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    CBL Cbl proto-oncogene [ Canis lupus familiaris (dog) ]

    Gene ID: 489369, updated on 17-Aug-2024

    Summary

    Official Symbol
    CBLprovided by VGNC
    Official Full Name
    Cbl proto-oncogeneprovided by VGNC
    Primary source
    VGNC:VGNC:38758
    See related
    Ensembl:ENSCAFG00845000222
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
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    Genomic context

    See CBL in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (14543644..14621193, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (14653516..14730936, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (14626100..14703693, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (14681808..14759290, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (14585944..14663491, complement)

    Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 26 Neighboring gene melanoma cell adhesion molecule Neighboring gene small nucleolar RNA SNORA19 Neighboring gene dynein regulatory complex subunit 12 homolog Neighboring gene NHERF family PDZ scaffold protein 4

    Genomic regions, transcripts, and products

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase CBL
    Names
    Cas-Br-M (murine) ecotropic retroviral transforming sequence
    XP_038330706.1
    XP_038330707.1
    XP_038330708.1
    XP_038364235.1
    XP_038364236.1
    XP_038391851.1
    XP_038391852.1
    XP_038391853.1
    XP_038456046.1
    XP_038456047.1
    XP_038456048.1
    XP_038520584.1
    XP_038520585.1
    XP_038520586.1
    XP_546487.4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051809.1 Reference ROS_Cfam_1.0

      Range
      14543644..14621193 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038664656.1XP_038520584.1  E3 ubiquitin-protein ligase CBL isoform X1

      UniProtKB/TrEMBL
      A0A8C0KHM7, A0A8C0T9I9, A0A8I3MBU4, A0A8P0TCM4
      Related
      ENSCAFP00845000244.1, ENSCAFT00845000345.1
      Conserved Domains (5) summary
      cd09920
      Location:253349
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14393
      Location:859898
      UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
      cd16709
      Location:359424
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:51169
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:176259
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    2. XM_038664658.1XP_038520586.1  E3 ubiquitin-protein ligase CBL isoform X3

      UniProtKB/TrEMBL
      A0A8C0T9I9
      Conserved Domains (4) summary
      cd09920
      Location:96192
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14393
      Location:702741
      UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
      cd16709
      Location:202267
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02761
      Location:19102
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    3. XM_038664657.1XP_038520585.1  E3 ubiquitin-protein ligase CBL isoform X2

      UniProtKB/TrEMBL
      A0A8C0T9I9
      Conserved Domains (5) summary
      cd09920
      Location:151247
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14393
      Location:757796
      UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
      cd16709
      Location:257322
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:74157
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049265.1 Alternate UMICH_Zoey_3.1

      Range
      14681808..14759290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038474778.1XP_038330706.1  E3 ubiquitin-protein ligase CBL isoform X1

      Conserved Domains (5) summary
      cd09920
      Location:253349
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14393
      Location:859898
      UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
      cd16709
      Location:359424
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:51169
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:176259
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    2. XM_038474780.1XP_038330708.1  E3 ubiquitin-protein ligase CBL isoform X3

      Conserved Domains (4) summary
      cd09920
      Location:96192
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14393
      Location:702741
      UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
      cd16709
      Location:202267
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02761
      Location:19102
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    3. XM_038474779.1XP_038330707.1  E3 ubiquitin-protein ligase CBL isoform X2

      Conserved Domains (5) summary
      cd09920
      Location:151247
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14393
      Location:757796
      UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
      cd16709
      Location:257322
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:74157
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

      Range
      14585944..14663491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038600118.1XP_038456046.1  E3 ubiquitin-protein ligase CBL isoform X1

      Conserved Domains (5) summary
      cd09920
      Location:253349
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14393
      Location:859898
      UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
      cd16709
      Location:359424
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:51169
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:176259
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    2. XM_038600120.1XP_038456048.1  E3 ubiquitin-protein ligase CBL isoform X3

      Conserved Domains (4) summary
      cd09920
      Location:96192
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14393
      Location:702741
      UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
      cd16709
      Location:202267
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02761
      Location:19102
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    3. XM_038600119.1XP_038456047.1  E3 ubiquitin-protein ligase CBL isoform X2

      Conserved Domains (5) summary
      cd09920
      Location:151247
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14393
      Location:757796
      UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
      cd16709
      Location:257322
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:74157
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

      Range
      14626100..14703693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038535923.1XP_038391851.1  E3 ubiquitin-protein ligase CBL isoform X4

      UniProtKB/TrEMBL
      A0A8C0T9I9
      Conserved Domains (5) summary
      cd09920
      Location:280376
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14393
      Location:886925
      UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
      cd16709
      Location:386451
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:78196
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:203286
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    2. XM_038535925.1XP_038391853.1  E3 ubiquitin-protein ligase CBL isoform X3

      UniProtKB/TrEMBL
      A0A8C0T9I9
      Conserved Domains (4) summary
      cd09920
      Location:96192
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14393
      Location:702741
      UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
      cd16709
      Location:202267
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02761
      Location:19102
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    3. XM_038535924.1XP_038391852.1  E3 ubiquitin-protein ligase CBL isoform X2

      UniProtKB/TrEMBL
      A0A8C0T9I9
      Conserved Domains (5) summary
      cd09920
      Location:151247
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14393
      Location:757796
      UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
      cd16709
      Location:257322
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:74157
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      14653516..14730936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_546487.7XP_546487.4  E3 ubiquitin-protein ligase CBL isoform X1

      UniProtKB/TrEMBL
      A0A8C0KHM7, A0A8C0T9I9, A0A8I3MBU4, A0A8P0TCM4
      Conserved Domains (5) summary
      cd09920
      Location:253349
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14393
      Location:859898
      UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
      cd16709
      Location:359424
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:51169
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:176259
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    2. XM_038508308.1XP_038364236.1  E3 ubiquitin-protein ligase CBL isoform X3

      UniProtKB/TrEMBL
      A0A8C0T9I9
      Conserved Domains (4) summary
      cd09920
      Location:96192
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14393
      Location:702741
      UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
      cd16709
      Location:202267
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02761
      Location:19102
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    3. XM_038508307.1XP_038364235.1  E3 ubiquitin-protein ligase CBL isoform X2

      UniProtKB/TrEMBL
      A0A8C0T9I9
      Conserved Domains (5) summary
      cd09920
      Location:151247
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14393
      Location:757796
      UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
      cd16709
      Location:257322
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:74157
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain