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    TNIK TRAF2 and NCK interacting kinase [ Canis lupus familiaris (dog) ]

    Gene ID: 488166, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TNIKprovided by VGNC
    Official Full Name
    TRAF2 and NCK interacting kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:47675
    See related
    Ensembl:ENSCAFG00845023590
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See TNIK in Genome Data Viewer
    Location:
    chromosome: 34
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 34 NC_051838.1 (35509666..35891390, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 34 NC_006616.4 (44437640..44820028, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 34 NC_049255.1 (35680818..36057283, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 34 NC_049294.1 (35448700..35832182, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 34 NC_049775.1 (35418689..35795208, complement)

    Chromosome 34 - NC_051838.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119867530 Neighboring gene uncharacterized LOC119867531 Neighboring gene zinc finger CCHC domain-containing protein 9-like Neighboring gene uncharacterized LOC111093943 Neighboring gene phospholipase D1 Neighboring gene transmembrane protein 212

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LOW QUALITY PROTEIN: TRAF2 and NCK-interacting protein kinase; TRAF2 and NCK-interacting protein kinase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051838.1 Reference ROS_Cfam_1.0

      Range
      35509666..35891390 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038446070.1 → XP_038301998.1  TRAF2 and NCK-interacting protein kinase isoform X4

      UniProtKB/TrEMBL
      A0A8C0YX54, A0A8I3PQQ5, A0A8P0T2I2
      Related
      ENSCAFP00845033395.1, ENSCAFT00845042596.1
      Conserved Domains (2) summary
      smart00036
      Location:1042 → 1340
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    2. XM_038446067.1 → XP_038301995.1  TRAF2 and NCK-interacting protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A8C0PMI3, A0A8C0SES9, A0A8I3PFQ4
      Related
      ENSCAFP00845032827.1, ENSCAFT00845041849.1
      Conserved Domains (2) summary
      smart00036
      Location:1071 → 1369
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    3. XM_038446072.1 → XP_038302000.1  TRAF2 and NCK-interacting protein kinase isoform X6

      UniProtKB/TrEMBL
      A0A8C0YX54
      Conserved Domains (2) summary
      smart00036
      Location:1013 → 1311
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    4. XM_038446068.1 → XP_038301996.1  TRAF2 and NCK-interacting protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A8C0SER7, A0A8I3PFN5, A0A8P0T5F1
      Related
      ENSCAFP00845033026.1, ENSCAFT00845042108.1
      Conserved Domains (2) summary
      smart00036
      Location:1063 → 1361
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    5. XM_038446069.1 → XP_038301997.1  TRAF2 and NCK-interacting protein kinase isoform X3

      UniProtKB/TrEMBL
      A0A8C0SES9, A0A8I3PZG4, A0A8P0T1F8
      Related
      ENSCAFP00845033184.1, ENSCAFT00845042329.1
      Conserved Domains (2) summary
      smart00036
      Location:1042 → 1340
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    6. XM_038446073.1 → XP_038302001.1  TRAF2 and NCK-interacting protein kinase isoform X7

      UniProtKB/TrEMBL
      A0A8C0YX54
      Conserved Domains (2) summary
      smart00036
      Location:1005 → 1303
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    7. XM_038446071.1 → XP_038301999.1  TRAF2 and NCK-interacting protein kinase isoform X5

      UniProtKB/TrEMBL
      A0A8C0SER7
      Conserved Domains (2) summary
      smart00036
      Location:1034 → 1332
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    8. XM_038446074.1 → XP_038302002.1  TRAF2 and NCK-interacting protein kinase isoform X8

      UniProtKB/TrEMBL
      A0A8I3PRG8, A0A8P0NGW6
      Related
      ENSCAFP00845033833.1, ENSCAFT00845043152.1
      Conserved Domains (2) summary
      smart00036
      Location:1000 → 1298
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:1 → 242
      PKc_like; Protein Kinases, catalytic domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049294.1 Alternate UMICH_Zoey_3.1

      Range
      35448700..35832182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038520258.1 → XP_038376186.1  LOW QUALITY PROTEIN: TRAF2 and NCK-interacting protein kinase isoform X3

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049775.1 Alternate UNSW_CanFamBas_1.0

      Range
      35418689..35795208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038648303.1 → XP_038504231.1  TRAF2 and NCK-interacting protein kinase isoform X1

      Conserved Domains (2) summary
      smart00036
      Location:1071 → 1369
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    2. XM_038648306.1 → XP_038504234.1  TRAF2 and NCK-interacting protein kinase isoform X4

      Conserved Domains (2) summary
      smart00036
      Location:1042 → 1340
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    3. XM_038648304.1 → XP_038504232.1  TRAF2 and NCK-interacting protein kinase isoform X2

      Conserved Domains (2) summary
      smart00036
      Location:1063 → 1361
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    4. XM_038648305.1 → XP_038504233.1  TRAF2 and NCK-interacting protein kinase isoform X3

      Conserved Domains (2) summary
      smart00036
      Location:1042 → 1340
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    5. XM_038648309.1 → XP_038504237.1  TRAF2 and NCK-interacting protein kinase isoform X7

      Conserved Domains (2) summary
      smart00036
      Location:1005 → 1303
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    6. XM_038648308.1 → XP_038504236.1  TRAF2 and NCK-interacting protein kinase isoform X6

      Conserved Domains (2) summary
      smart00036
      Location:1013 → 1311
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    7. XM_038648307.1 → XP_038504235.1  TRAF2 and NCK-interacting protein kinase isoform X5

      Conserved Domains (2) summary
      smart00036
      Location:1034 → 1332
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    8. XM_038648310.1 → XP_038504238.1  TRAF2 and NCK-interacting protein kinase isoform X8

      Conserved Domains (2) summary
      smart00036
      Location:1000 → 1298
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:1 → 242
      PKc_like; Protein Kinases, catalytic domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049255.1 Alternate UU_Cfam_GSD_1.0

      Range
      35680818..36057283 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038583888.1 → XP_038439816.1  TRAF2 and NCK-interacting protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A8C0PMI3, A0A8C0SES9, A0A8I3PFQ4
      Conserved Domains (2) summary
      smart00036
      Location:1071 → 1369
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    2. XM_038583893.1 → XP_038439821.1  TRAF2 and NCK-interacting protein kinase isoform X6

      UniProtKB/TrEMBL
      A0A8C0YX54
      Conserved Domains (2) summary
      smart00036
      Location:1013 → 1311
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    3. XM_038583891.1 → XP_038439819.1  TRAF2 and NCK-interacting protein kinase isoform X4

      UniProtKB/TrEMBL
      A0A8C0YX54, A0A8I3PQQ5, A0A8P0T2I2
      Conserved Domains (2) summary
      smart00036
      Location:1042 → 1340
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    4. XM_038583889.1 → XP_038439817.1  TRAF2 and NCK-interacting protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A8C0SER7, A0A8I3PFN5, A0A8P0T5F1
      Conserved Domains (2) summary
      smart00036
      Location:1063 → 1361
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    5. XM_038583890.1 → XP_038439818.1  TRAF2 and NCK-interacting protein kinase isoform X3

      UniProtKB/TrEMBL
      A0A8C0SES9, A0A8I3PZG4, A0A8P0T1F8
      Conserved Domains (2) summary
      smart00036
      Location:1042 → 1340
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    6. XM_038583894.1 → XP_038439822.1  TRAF2 and NCK-interacting protein kinase isoform X7

      UniProtKB/TrEMBL
      A0A8C0YX54
      Conserved Domains (2) summary
      smart00036
      Location:1005 → 1303
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    7. XM_038583892.1 → XP_038439820.1  TRAF2 and NCK-interacting protein kinase isoform X5

      UniProtKB/TrEMBL
      A0A8C0SER7
      Conserved Domains (2) summary
      smart00036
      Location:1034 → 1332
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    8. XM_038583895.1 → XP_038439823.1  TRAF2 and NCK-interacting protein kinase isoform X8

      UniProtKB/TrEMBL
      A0A8I3PRG8, A0A8P0NGW6
      Conserved Domains (2) summary
      smart00036
      Location:1000 → 1298
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:1 → 242
      PKc_like; Protein Kinases, catalytic domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006616.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      44437640..44820028 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038462813.1 → XP_038318741.1  TRAF2 and NCK-interacting protein kinase isoform X4

      UniProtKB/TrEMBL
      A0A8C0YX54, A0A8I3PQQ5, A0A8P0T2I2
      Conserved Domains (2) summary
      smart00036
      Location:1042 → 1340
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    2. XM_038462810.1 → XP_038318738.1  TRAF2 and NCK-interacting protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A8C0PMI3, A0A8C0SES9, A0A8I3PFQ4
      Conserved Domains (2) summary
      smart00036
      Location:1071 → 1369
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    3. XM_038462816.1 → XP_038318744.1  TRAF2 and NCK-interacting protein kinase isoform X6

      UniProtKB/TrEMBL
      A0A8C0YX54
      Conserved Domains (2) summary
      smart00036
      Location:1013 → 1311
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    4. XM_038462811.1 → XP_038318739.1  TRAF2 and NCK-interacting protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A8C0SER7, A0A8I3PFN5, A0A8P0T5F1
      Conserved Domains (2) summary
      smart00036
      Location:1063 → 1361
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    5. XM_038462812.1 → XP_038318740.1  TRAF2 and NCK-interacting protein kinase isoform X3

      UniProtKB/TrEMBL
      A0A8C0SES9, A0A8I3PZG4, A0A8P0T1F8
      Conserved Domains (2) summary
      smart00036
      Location:1042 → 1340
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    6. XM_038462817.1 → XP_038318745.1  TRAF2 and NCK-interacting protein kinase isoform X7

      UniProtKB/TrEMBL
      A0A8C0YX54
      Conserved Domains (2) summary
      smart00036
      Location:1005 → 1303
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    7. XM_038462814.1 → XP_038318742.1  TRAF2 and NCK-interacting protein kinase isoform X5

      UniProtKB/TrEMBL
      A0A8C0SER7
      Conserved Domains (2) summary
      smart00036
      Location:1034 → 1332
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    8. XM_022414124.2 → XP_022269832.1  TRAF2 and NCK-interacting protein kinase isoform X8

      UniProtKB/TrEMBL
      A0A8I3PRG8, A0A8P0NGW6
      Conserved Domains (2) summary
      smart00036
      Location:1000 → 1298
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:1 → 242
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
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