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    KLHL6 kelch like family member 6 [ Canis lupus familiaris (dog) ]

    Gene ID: 488096, updated on 17-Aug-2024

    Summary

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    Official Symbol
    KLHL6provided by VGNC
    Official Full Name
    kelch like family member 6provided by VGNC
    Primary source
    VGNC:VGNC:42475
    See related
    Ensembl:ENSCAFG00845022563
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See KLHL6 in Genome Data Viewer
    Location:
    chromosome: 34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 34 NC_051838.1 (16351275..16464989, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 34 NC_006616.4 (20531581..20645243, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 34 NC_049255.1 (16614814..16728495, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 34 NC_049294.1 (16390376..16503817, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 34 NC_049775.1 (16376664..16438114, complement)

    Chromosome 34 - NC_051838.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111093847 Neighboring gene uncharacterized LOC111093848 Neighboring gene small nucleolar RNA U13 Neighboring gene small nucleolar RNA U13 Neighboring gene cofilin-1-like Neighboring gene kelch like family member 24 Neighboring gene YEATS domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in germinal center formation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kelch-like protein 6
    Names
    kelch-like 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051838.1 Reference ROS_Cfam_1.0

      Range
      16351275..16464989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038445677.1 → XP_038301605.1  kelch-like protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A8C0TJD4, A0A8I3PFF2
      Conserved Domains (5) summary
      PHA03098
      Location:1 → 466
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:271 → 308
      Kelch; KELCH repeat [structural motif]
      cd18446
      Location:70 → 177
      BACK_KLHL6; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6)
      cl38908
      Location:1 → 77
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam01344
      Location:449 → 486
      Kelch_1; Kelch motif

    2. XM_038445678.1 → XP_038301606.1  kelch-like protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A8C0TJD4, A0A8I3PFF2
      Conserved Domains (5) summary
      PHA03098
      Location:1 → 466
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:271 → 308
      Kelch; KELCH repeat [structural motif]
      cd18446
      Location:70 → 177
      BACK_KLHL6; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6)
      cl38908
      Location:1 → 77
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam01344
      Location:449 → 486
      Kelch_1; Kelch motif

    3. XM_038445676.1 → XP_038301604.1  kelch-like protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A8C0JJS1, A0A8C0TIA1
      Related
      ENSCAFP00845031216.1, ENSCAFT00845039858.1
      Conserved Domains (5) summary
      PHA03098
      Location:84 → 563
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:368 → 405
      Kelch; KELCH repeat [structural motif]
      cd18236
      Location:46 → 174
      BTB_POZ_KLHL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6)
      cd18446
      Location:167 → 274
      BACK_KLHL6; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6)
      pfam01344
      Location:546 → 583
      Kelch_1; Kelch motif

    4. XM_038445679.1 → XP_038301607.1  kelch-like protein 6 isoform X3

      Conserved Domains (4) summary
      sd00038
      Location:368 → 405
      Kelch; KELCH repeat [structural motif]
      cd18236
      Location:46 → 174
      BTB_POZ_KLHL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6)
      cd18446
      Location:167 → 274
      BACK_KLHL6; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6)
      pfam01344
      Location:411 → 449
      Kelch_1; Kelch motif

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049294.1 Alternate UMICH_Zoey_3.1

      Range
      16390376..16503817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038519864.1 → XP_038375792.1  kelch-like protein 6 isoform X1

      Conserved Domains (5) summary
      PHA03098
      Location:1 → 466
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:271 → 308
      Kelch; KELCH repeat [structural motif]
      cd18446
      Location:70 → 177
      BACK_KLHL6; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6)
      cl38908
      Location:1 → 77
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam01344
      Location:449 → 486
      Kelch_1; Kelch motif

    2. XM_038519865.1 → XP_038375793.1  kelch-like protein 6 isoform X1

      Conserved Domains (5) summary
      PHA03098
      Location:1 → 466
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:271 → 308
      Kelch; KELCH repeat [structural motif]
      cd18446
      Location:70 → 177
      BACK_KLHL6; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6)
      cl38908
      Location:1 → 77
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam01344
      Location:449 → 486
      Kelch_1; Kelch motif

    3. XM_038519863.1 → XP_038375791.1  kelch-like protein 6 isoform X2

      Conserved Domains (5) summary
      PHA03098
      Location:84 → 563
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:368 → 405
      Kelch; KELCH repeat [structural motif]
      cd18236
      Location:46 → 174
      BTB_POZ_KLHL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6)
      cd18446
      Location:167 → 274
      BACK_KLHL6; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6)
      pfam01344
      Location:546 → 583
      Kelch_1; Kelch motif

    4. XM_038519866.1 → XP_038375794.1  kelch-like protein 6 isoform X3

      Conserved Domains (4) summary
      sd00038
      Location:368 → 405
      Kelch; KELCH repeat [structural motif]
      cd18236
      Location:46 → 174
      BTB_POZ_KLHL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6)
      cd18446
      Location:167 → 274
      BACK_KLHL6; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6)
      pfam01344
      Location:411 → 449
      Kelch_1; Kelch motif

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049775.1 Alternate UNSW_CanFamBas_1.0

      Range
      16376664..16438114 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038647911.1 → XP_038503839.1  kelch-like protein 6 isoform X2

      Conserved Domains (5) summary
      PHA03098
      Location:84 → 563
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:368 → 405
      Kelch; KELCH repeat [structural motif]
      cd18236
      Location:46 → 174
      BTB_POZ_KLHL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6)
      cd18446
      Location:167 → 274
      BACK_KLHL6; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6)
      pfam01344
      Location:546 → 583
      Kelch_1; Kelch motif

    2. XM_038647912.1 → XP_038503840.1  kelch-like protein 6 isoform X3

      Conserved Domains (4) summary
      sd00038
      Location:368 → 405
      Kelch; KELCH repeat [structural motif]
      cd18236
      Location:46 → 174
      BTB_POZ_KLHL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6)
      cd18446
      Location:167 → 274
      BACK_KLHL6; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6)
      pfam01344
      Location:411 → 449
      Kelch_1; Kelch motif

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049255.1 Alternate UU_Cfam_GSD_1.0

      Range
      16614814..16728495 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038583503.1 → XP_038439431.1  kelch-like protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A8C0TJD4, A0A8I3PFF2
      Conserved Domains (5) summary
      PHA03098
      Location:1 → 466
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:271 → 308
      Kelch; KELCH repeat [structural motif]
      cd18446
      Location:70 → 177
      BACK_KLHL6; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6)
      cl38908
      Location:1 → 77
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam01344
      Location:449 → 486
      Kelch_1; Kelch motif

    2. XM_038583504.1 → XP_038439432.1  kelch-like protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A8C0TJD4, A0A8I3PFF2
      Conserved Domains (5) summary
      PHA03098
      Location:1 → 466
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:271 → 308
      Kelch; KELCH repeat [structural motif]
      cd18446
      Location:70 → 177
      BACK_KLHL6; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6)
      cl38908
      Location:1 → 77
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam01344
      Location:449 → 486
      Kelch_1; Kelch motif

    3. XM_038583502.1 → XP_038439430.1  kelch-like protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A8C0JJS1, A0A8C0TIA1
      Conserved Domains (5) summary
      PHA03098
      Location:84 → 563
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:368 → 405
      Kelch; KELCH repeat [structural motif]
      cd18236
      Location:46 → 174
      BTB_POZ_KLHL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6)
      cd18446
      Location:167 → 274
      BACK_KLHL6; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6)
      pfam01344
      Location:546 → 583
      Kelch_1; Kelch motif

    4. XM_038583505.1 → XP_038439433.1  kelch-like protein 6 isoform X3

      Conserved Domains (4) summary
      sd00038
      Location:368 → 405
      Kelch; KELCH repeat [structural motif]
      cd18236
      Location:46 → 174
      BTB_POZ_KLHL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6)
      cd18446
      Location:167 → 274
      BACK_KLHL6; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6)
      pfam01344
      Location:411 → 449
      Kelch_1; Kelch motif

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006616.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      20531581..20645243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_022414172.1 → XP_022269880.1  kelch-like protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A8C0TJD4, A0A8I3PFF2
      Conserved Domains (5) summary
      PHA03098
      Location:1 → 466
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:271 → 308
      Kelch; KELCH repeat [structural motif]
      cd18446
      Location:70 → 177
      BACK_KLHL6; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6)
      cl38908
      Location:1 → 77
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam01344
      Location:449 → 486
      Kelch_1; Kelch motif

    2. XM_038462804.1 → XP_038318732.1  kelch-like protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A8C0TJD4, A0A8I3PFF2
      Conserved Domains (5) summary
      PHA03098
      Location:1 → 466
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:271 → 308
      Kelch; KELCH repeat [structural motif]
      cd18446
      Location:70 → 177
      BACK_KLHL6; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6)
      cl38908
      Location:1 → 77
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam01344
      Location:449 → 486
      Kelch_1; Kelch motif

    3. XM_545220.7 → XP_545220.3  kelch-like protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A8C0JJS1, A0A8C0TIA1
      Conserved Domains (5) summary
      PHA03098
      Location:84 → 563
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:368 → 405
      Kelch; KELCH repeat [structural motif]
      cd18236
      Location:46 → 174
      BTB_POZ_KLHL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6)
      cd18446
      Location:167 → 274
      BACK_KLHL6; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6)
      pfam01344
      Location:546 → 583
      Kelch_1; Kelch motif

    4. XM_022414173.2 → XP_022269881.1  kelch-like protein 6 isoform X3

      Conserved Domains (4) summary
      sd00038
      Location:368 → 405
      Kelch; KELCH repeat [structural motif]
      cd18236
      Location:46 → 174
      BTB_POZ_KLHL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6)
      cd18446
      Location:167 → 274
      BACK_KLHL6; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6)
      pfam01344
      Location:411 → 449
      Kelch_1; Kelch motif
    Nucleotide Protein
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