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    NPPB natriuretic peptide B [ Canis lupus familiaris (dog) ]

    Gene ID: 487441, updated on 5-Mar-2024

    Summary

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    Official Symbol
    NPPBprovided by VGNC
    Official Full Name
    natriuretic peptide Bprovided by VGNC
    Primary source
    VGNC:VGNC:43926
    See related
    Ensembl:ENSCAFG00845001994
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    BNP; Iso-ANP
    Orthologs
    human mouse all
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    Genomic context

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    See NPPB in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (85060368..85062010)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (80929289..80930932)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (83872280..83873924)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (81809597..81811239)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (82809514..82811156)

    Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene KIAA2013 Neighboring gene U5 spliceosomal RNA Neighboring gene natriuretic peptide A Neighboring gene chloride voltage-gated channel 6 Neighboring gene methylenetetrahydrofolate reductase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Resting and dobutamine stress test induced serum concentrations of brain natriuretic peptide in German Shepherd dogs. Spasojević Kosić L, et al. Res Vet Sci, 2012 Dec. PMID 22537461
    2. Evaluation of plasma N-terminal pro-B-type natriuretic peptide concentrations in dogs with and without cardiac disease. Ettinger SJ, et al. J Am Vet Med Assoc, 2012 Jan 15. PMID 22217025
    3. The cardiac biomarker NT-proBNP is increased in dogs with azotemia. Raffan E, et al. J Vet Intern Med, 2009 Nov-Dec. PMID 19709357
    4. Evaluation of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in dogs with mitral valve insufficiency. Takemura N, et al. J Vet Med Sci, 2009 Jul. PMID 19652480
    5. Canine heterophilic antibodies as a source of false-positive B-type natriuretic peptide sandwich ELISA results. Solter PF, et al. Vet Clin Pathol, 2008 Mar. PMID 18366550

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results indicated that plasma atrial natriuretic peptide and natriuretic peptide precursor B (NT-proBNP) responded to severe, but not mild, pulmonary arterial hypertension
      Title: Diagnostic utility of NT-proBNP and ANP in a canine model of chronic embolic pulmonary hypertension.
    2. These data suggest that BNP is not increased in aged dogs with normal cardiac systolic function and renal function, and that myocardial ischemia leads to a significant increase in BNP concentrations even in dogs with normal left ventricular function.
      Title: Resting and dobutamine stress test induced serum concentrations of brain natriuretic peptide in German Shepherd dogs.
    3. The use of NT-pro-BNP and troponin I levels as prognostic indicators for canine heart failure is reported.
      Title: NT-pro-BNP and troponin I as predictors of mortality in dogs with heart failure.
    4. Mean NT-proBNP concentration was significantly increased in dogs with cardiac-related dyspnea or coughing, compared with dogs in which these signs were noncardiac related.
      Title: Evaluation of plasma N-terminal pro-B-type natriuretic peptide concentrations in dogs with and without cardiac disease.
    5. [NT-proBNP] concentration is significantly higher in dogs with pre-capillary pulmonary hypertension (PH) when compared to dogs with respiratory disease without PH; [NT-proANP] and [cTnI] were not elevated in dogs with pre-capillary PH.
      Title: NT-proBNP, NT-proANP and cTnI concentrations in dogs with pre-capillary pulmonary hypertension.
    6. Azotemia results in NT-proBNP being increased to concentrations reported as diagnostic of heart disease or heart failure in dogs.
      Title: The cardiac biomarker NT-proBNP is increased in dogs with azotemia.
    7. The use of Plasma atrial natriuretic peptide (proANP 31-67), B-type natriuretic peptide (Nt-proBNP) and endothelin-1 (ET-1) concentrations as disease markers in dogs with valvular heart disease is reported.[proANP; NT-proBNP]
      Title: Plasma atrial natriuretic peptide (proANP 31-67), B-type natriuretic peptide (Nt-proBNP) and endothelin-1 (ET-1) concentrations in dogs with chronic degenerative valvular disease (CDVD).
    8. These findings could indicate that plasma NT-proBNP concentration was significantly associated with the severity of heart failure due to mitral valve insufficiency in dogs.
      Title: Evaluation of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in dogs with mitral valve insufficiency.
    9. Intrapericardial endothelin-1 did not alter pericardial BNP levels.
      Title: Effects of intrapericardially administered endothelin-1 on pericardial natriuretic peptide concentrations of the in situ dog heart.
    10. differential regulation of gene expression of cardiotrophin-1 and BNP in the heart during the progression of congestive heart failure; ventricular CT-1 gene activation precedes ventricular BNP gene activation [brain natriuretic peptide=BNP]
      Title: Ventricular cardiotrophin-1 activation precedes BNP in experimental heart failure.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hormone receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cGMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of systemic arterial blood pressure IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in receptor guanylyl cyclase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    natriuretic peptides B
    Names
    Gamma-brain natriuretic peptide
    Natriuretic peptides B
    brain natriuretic factor prohormone
    brain natriuretic peptide
    natriuretic peptide precursor B
    preproBNP
    proBNP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051806.1 Reference ROS_Cfam_1.0

      Range
      85060368..85062010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038657971.1 → XP_038513899.1  natriuretic peptides B

      UniProtKB/Swiss-Prot
      P16859
      UniProtKB/TrEMBL
      A0A8I3MHJ9
      Related
      ENSCAFP00845002768.1, ENSCAFT00845003490.1
      Conserved Domains (1) summary
      pfam00212
      Location:105 → 135
      ANP; Atrial natriuretic peptide

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049262.1 Alternate UMICH_Zoey_3.1

      Range
      81809597..81811239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038468934.1 → XP_038324862.1  natriuretic peptides B

      Conserved Domains (1) summary
      pfam00212
      Location:105 → 135
      ANP; Atrial natriuretic peptide

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

      Range
      82809514..82811156
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038593894.1 → XP_038449822.1  natriuretic peptides B

      Conserved Domains (1) summary
      pfam00212
      Location:105 → 135
      ANP; Atrial natriuretic peptide

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

      Range
      83872280..83873924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038529657.1 → XP_038385585.1  natriuretic peptides B

      UniProtKB/Swiss-Prot
      P16859
      UniProtKB/TrEMBL
      A0A8I3MHJ9
      Conserved Domains (1) summary
      pfam00212
      Location:105 → 135
      ANP; Atrial natriuretic peptide

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      80929289..80930932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014111456.3 → XP_013966931.1  natriuretic peptides B

      UniProtKB/Swiss-Prot
      P16859
      UniProtKB/TrEMBL
      A0A8P0PRD3
      Conserved Domains (1) summary
      pfam00212
      Location:105 → 135
      ANP; Atrial natriuretic peptide
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16859.1 GenPept UniProtKB/Swiss-Prot:P16859

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    Research Materials