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    EPHB2 EPH receptor B2 [ Canis lupus familiaris (dog) ]

    Gene ID: 487380, updated on 17-Aug-2024

    Summary

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    Official Symbol
    EPHB2provided by VGNC
    Official Full Name
    EPH receptor B2provided by VGNC
    Primary source
    VGNC:VGNC:40411
    See related
    Ensembl:ENSCAFG00845000323
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See EPHB2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (76986320..77110768, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (72932009..73056438, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (75819294..75943710, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (73807403..73931772, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (74815673..74940002, complement)

    Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene lactamase beta like 1 Neighboring gene testis expressed 46 Neighboring gene uncharacterized LOC111093615 Neighboring gene uncharacterized LOC119870432 Neighboring gene uncharacterized LOC119870434 Neighboring gene complement C1q B chain Neighboring gene complement C1q C chain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane-ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in central nervous system projection neuron axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ephrin type-B receptor 2
    XP_005617880.1
    XP_005617881.1
    XP_013966165.1
    XP_038326722.1
    XP_038326723.1
    XP_038326724.1
    XP_038387585.1
    XP_038387586.1
    XP_038387587.1
    XP_038451815.1
    XP_038451816.1
    XP_038451817.1
    XP_038451818.1
    XP_038515894.1
    XP_038515895.1
    XP_038515896.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051806.1 Reference ROS_Cfam_1.0

      Range
      76986320..77110768 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038659968.1 → XP_038515896.1  ephrin type-B receptor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LXA4
      Conserved Domains (5) summary
      cd05065
      Location:563 → 831
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:857 → 927
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      cd10477
      Location:1 → 173
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:303 → 398
      fn3; Fibronectin type III domain
      pfam14575
      Location:490 → 564
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    2. XM_038659967.1 → XP_038515895.1  ephrin type-B receptor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0L4K6, A0A8C0LXA4
      Conserved Domains (5) summary
      cd05065
      Location:593 → 861
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:887 → 957
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      cd10477
      Location:1 → 173
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:414 → 497
      fn3; Fibronectin type III domain
      pfam14575
      Location:521 → 594
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    3. XM_038659966.1 → XP_038515894.1  ephrin type-B receptor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LXA4
      Related
      ENSCAFP00845000356.1, ENSCAFT00845000518.1
      Conserved Domains (5) summary
      cd05065
      Location:594 → 862
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:888 → 958
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      cd10477
      Location:1 → 173
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:414 → 497
      fn3; Fibronectin type III domain
      pfam14575
      Location:521 → 595
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049262.1 Alternate UMICH_Zoey_3.1

      Range
      73807403..73931772 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038470796.1 → XP_038326724.1  ephrin type-B receptor 2 isoform X3

      Conserved Domains (5) summary
      cd05065
      Location:563 → 831
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:857 → 927
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      cd10477
      Location:1 → 173
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:303 → 398
      fn3; Fibronectin type III domain
      pfam14575
      Location:490 → 564
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    2. XM_038470795.1 → XP_038326723.1  ephrin type-B receptor 2 isoform X2

      Conserved Domains (5) summary
      cd05065
      Location:593 → 861
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:887 → 957
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      cd10477
      Location:1 → 173
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:414 → 497
      fn3; Fibronectin type III domain
      pfam14575
      Location:521 → 594
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    3. XM_038470794.1 → XP_038326722.1  ephrin type-B receptor 2 isoform X1

      Conserved Domains (5) summary
      cd05065
      Location:594 → 862
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:888 → 958
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      cd10477
      Location:1 → 173
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:414 → 497
      fn3; Fibronectin type III domain
      pfam14575
      Location:521 → 595
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

      Range
      74815673..74940002 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038595890.1 → XP_038451818.1  ephrin type-B receptor 2 isoform X7

    2. XM_038595889.1 → XP_038451817.1  ephrin type-B receptor 2 isoform X6

    3. XM_038595888.1 → XP_038451816.1  ephrin type-B receptor 2 isoform X5

    4. XM_038595887.1 → XP_038451815.1  ephrin type-B receptor 2 isoform X4

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

      Range
      75819294..75943710 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038531659.1 → XP_038387587.1  ephrin type-B receptor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LXA4
      Conserved Domains (5) summary
      cd05065
      Location:563 → 831
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:857 → 927
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      cd10477
      Location:1 → 173
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:303 → 398
      fn3; Fibronectin type III domain
      pfam14575
      Location:490 → 564
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    2. XM_038531658.1 → XP_038387586.1  ephrin type-B receptor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0L4K6, A0A8C0LXA4
      Conserved Domains (5) summary
      cd05065
      Location:593 → 861
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:887 → 957
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      cd10477
      Location:1 → 173
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:414 → 497
      fn3; Fibronectin type III domain
      pfam14575
      Location:521 → 594
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    3. XM_038531657.1 → XP_038387585.1  ephrin type-B receptor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LXA4
      Conserved Domains (5) summary
      cd05065
      Location:594 → 862
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:888 → 958
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      cd10477
      Location:1 → 173
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:414 → 497
      fn3; Fibronectin type III domain
      pfam14575
      Location:521 → 595
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      72932009..73056438 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014110690.3 → XP_013966165.1  ephrin type-B receptor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LXA4
      Conserved Domains (5) summary
      cd05065
      Location:563 → 831
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:857 → 927
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      cd10477
      Location:1 → 173
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:303 → 398
      fn3; Fibronectin type III domain
      pfam14575
      Location:490 → 564
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    2. XM_005617824.4 → XP_005617881.1  ephrin type-B receptor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0L4K6, A0A8C0LXA4
      Conserved Domains (5) summary
      cd05065
      Location:593 → 861
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:887 → 957
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      cd10477
      Location:1 → 173
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:414 → 497
      fn3; Fibronectin type III domain
      pfam14575
      Location:521 → 594
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    3. XM_005617823.4 → XP_005617880.1  ephrin type-B receptor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LXA4
      Conserved Domains (5) summary
      cd05065
      Location:594 → 862
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:888 → 958
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      cd10477
      Location:1 → 173
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:414 → 497
      fn3; Fibronectin type III domain
      pfam14575
      Location:521 → 595
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    Nucleotide Protein
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