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    MAP3K6 mitogen-activated protein kinase kinase kinase 6 [ Canis lupus familiaris (dog) ]

    Gene ID: 487345, updated on 17-Aug-2024

    Summary

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    Official Symbol
    MAP3K6provided by VGNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase 6provided by VGNC
    Primary source
    VGNC:VGNC:42976
    See related
    Ensembl:ENSCAFG00845010722
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See MAP3K6 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (73465488..73478984)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (69481563..69494283)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (72299020..72312519)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (70291490..70304986)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (71303724..71315393)

    Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111093304 Neighboring gene CD164 molecule like 2 Neighboring gene ficolin 3 Neighboring gene synaptotagmin like 1 Neighboring gene transmembrane protein 222 Neighboring gene WD and tetratricopeptide repeats 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables MAP kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 6; mitogen-activated protein kinase kinase kinase 6
    XP_038310772.1
    XP_038327077.1
    XP_038385520.1
    XP_038449753.1
    XP_038513832.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051806.1 Reference ROS_Cfam_1.0

      Range
      73465488..73478984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038657904.1 → XP_038513832.1  mitogen-activated protein kinase kinase kinase 6 isoform X1

      UniProtKB/TrEMBL
      A0A8C0Q431, A0A8I3NBA4
      Related
      ENSCAFP00845014900.1, ENSCAFT00845019073.1
      Conserved Domains (3) summary
      cd06624
      Location:670 → 937
      STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
      pfam13281
      Location:160 → 538
      DUF4071; Domain of unknown function (DUF4071)
      pfam19039
      Location:554 → 647
      ASK_PH; ASK kinase PH domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049262.1 Alternate UMICH_Zoey_3.1

      Range
      70291490..70304986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038471149.1 → XP_038327077.1  mitogen-activated protein kinase kinase kinase 6 isoform X1

      Conserved Domains (3) summary
      cd06624
      Location:670 → 937
      STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
      pfam13281
      Location:160 → 538
      DUF4071; Domain of unknown function (DUF4071)
      pfam19039
      Location:554 → 647
      ASK_PH; ASK kinase PH domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

      Range
      71303724..71315393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038593825.1 → XP_038449753.1  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 6 isoform X2

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

      Range
      72299020..72312519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038529592.1 → XP_038385520.1  mitogen-activated protein kinase kinase kinase 6 isoform X1

      UniProtKB/TrEMBL
      A0A8C0Q431, A0A8I3NBA4
      Conserved Domains (3) summary
      cd06624
      Location:670 → 937
      STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
      pfam13281
      Location:160 → 538
      DUF4071; Domain of unknown function (DUF4071)
      pfam19039
      Location:554 → 647
      ASK_PH; ASK kinase PH domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      69481563..69494283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038454844.1 → XP_038310772.1  mitogen-activated protein kinase kinase kinase 6 isoform X3

      UniProtKB/TrEMBL
      A0A8C0Q431, A0A8I3NBA4
      Conserved Domains (3) summary
      cd06624
      Location:692 → 959
      STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
      pfam13281
      Location:182 → 560
      DUF4071; Domain of unknown function (DUF4071)
      pfam19039
      Location:576 → 669
      ASK_PH; ASK kinase PH domain
    Nucleotide Protein
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