GAD2 glutamate decarboxylase 2 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: GAD2provided by VGNC
Official Full Name: glutamate decarboxylase 2provided by VGNC
Primary source: VGNC:VGNC:41068
See related: Ensembl:ENSCAFG00845003895
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: GAD65
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	2	NC_051806.1 (5562197..5647420, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	2	NC_006584.4 (6118684..6180324, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	2	NC_049223.1 (5177275..5262494, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	2	NC_049262.1 (4932241..5017384, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	2	NC_049743.1 (5011639..5096787, complement)

Chromosome 2 - NC_051806.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GAT-1 mRNA in the hypothalamus and hippocampus and GAD65 mRNA in the dorsal thalamus are upregulated when propofol uptake reaches an equilibrium in the brain of dogs.
Title: [GAT-1 and GAD65 mRNA expressions in different brain regions in dogs at brain propofol uptake equilibrium].
Results indicate that the distribution of GAD65-immunoreactive structures is different from GAD67-immunoreactive structures and that their immunoreactivity in the aged dogs is much higher than the adult dogs.
Title: Comparison of GAD65 and 67 immunoreactivity in the lumbar spinal cord between young adult and aged dogs.
These data indicate that serological reactivity to GAD65 and IA-2 is present in a proportion of diabetic dogs and suggest that, in some cases, canine diabetes is associated with an autoimmune response to these antigens.
Title: Autoantibodies to GAD65 and IA-2 in canine diabetes mellitus.

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General gene information

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Markers

MARC_35306-35307:1068144838:1 (e-PCR)
- UniSTS:269271

Gad2 (e-PCR), detects polymorphism
- UniSTS:266999

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables glutamate decarboxylase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in gamma-aminobutyrate shunt	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: glutamate decarboxylase 2

Names: 65 kDa glutamic acid decarboxylase; GAD-65; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); glutamic acid decarboxylase 2

NP_001070907.1

EC 4.1.1.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.