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    C1S complement C1s [ Canis lupus familiaris (dog) ]

    Gene ID: 486714, updated on 5-Mar-2024

    Summary

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    Official Symbol
    C1Sprovided by VGNC
    Official Full Name
    complement C1sprovided by VGNC
    Primary source
    VGNC:VGNC:38588
    See related
    Ensembl:ENSCAFG00845025415
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See C1S in Genome Data Viewer
    Location:
    chromosome: 27
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (38328637..38338284, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (8630918..8640567)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (8109060..8118714)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (38203588..38213240, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (38244607..38254261, complement)

    Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene complement C1r subcomponent like Neighboring gene complement C1r Neighboring gene lysophosphatidylcholine acyltransferase 3 Neighboring gene EMG1 N1-specific pseudouridine methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in complement activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    complement C1s subcomponent
    XP_005637267.1
    XP_038295052.1
    XP_038295053.1
    XP_038369717.1
    XP_038369718.1
    XP_038432585.1
    XP_038432586.1
    XP_038497559.1
    XP_038497560.1
    XP_853320.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051831.1 Reference ROS_Cfam_1.0

      Range
      38328637..38338284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038439125.1 → XP_038295053.1  complement C1s subcomponent

      UniProtKB/TrEMBL
      A0A8C0JQU2, A0A8C0TNV8, A0A8P0NG06
      Related
      ENSCAFP00845035154.1, ENSCAFT00845044857.1
      Conserved Domains (5) summary
      cd00033
      Location:303 → 361
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00020
      Location:443 → 682
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:24 → 135
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00431
      Location:181 → 293
      CUB; CUB domain
      pfam14670
      Location:149 → 177
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. XM_038439124.1 → XP_038295052.1  complement C1s subcomponent

      UniProtKB/TrEMBL
      A0A8C0JQU2, A0A8C0TNV8, A0A8P0NG06
      Related
      ENSCAFP00845035317.1, ENSCAFT00845045055.1
      Conserved Domains (5) summary
      cd00033
      Location:303 → 361
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00020
      Location:443 → 682
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:24 → 135
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00431
      Location:181 → 293
      CUB; CUB domain
      pfam14670
      Location:149 → 177
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049287.1 Alternate UMICH_Zoey_3.1

      Range
      38203588..38213240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038513790.1 → XP_038369718.1  complement C1s subcomponent

      Conserved Domains (5) summary
      cd00033
      Location:303 → 361
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00020
      Location:443 → 682
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:24 → 135
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00431
      Location:181 → 293
      CUB; CUB domain
      pfam14670
      Location:149 → 177
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. XM_038513789.1 → XP_038369717.1  complement C1s subcomponent

      Conserved Domains (5) summary
      cd00033
      Location:303 → 361
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00020
      Location:443 → 682
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:24 → 135
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00431
      Location:181 → 293
      CUB; CUB domain
      pfam14670
      Location:149 → 177
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

      Range
      38244607..38254261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038641632.1 → XP_038497560.1  complement C1s subcomponent

      Conserved Domains (5) summary
      cd00033
      Location:303 → 361
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00020
      Location:443 → 682
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:24 → 135
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00431
      Location:181 → 293
      CUB; CUB domain
      pfam14670
      Location:149 → 177
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. XM_038641631.1 → XP_038497559.1  complement C1s subcomponent

      Conserved Domains (5) summary
      cd00033
      Location:303 → 361
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00020
      Location:443 → 682
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:24 → 135
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00431
      Location:181 → 293
      CUB; CUB domain
      pfam14670
      Location:149 → 177
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

      Range
      8109060..8118714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038576657.1 → XP_038432585.1  complement C1s subcomponent

      UniProtKB/TrEMBL
      A0A8C0JQU2, A0A8C0TNV8, A0A8P0NG06
      Conserved Domains (5) summary
      cd00033
      Location:303 → 361
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00020
      Location:443 → 682
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:24 → 135
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00431
      Location:181 → 293
      CUB; CUB domain
      pfam14670
      Location:149 → 177
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. XM_038576658.1 → XP_038432586.1  complement C1s subcomponent

      UniProtKB/TrEMBL
      A0A8C0JQU2, A0A8C0TNV8, A0A8P0NG06
      Conserved Domains (5) summary
      cd00033
      Location:303 → 361
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00020
      Location:443 → 682
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:24 → 135
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00431
      Location:181 → 293
      CUB; CUB domain
      pfam14670
      Location:149 → 177
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      8630918..8640567
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_848227.6 → XP_853320.1  complement C1s subcomponent

      See identical proteins and their annotated locations for XP_853320.1

      UniProtKB/TrEMBL
      A0A8C0JQU2, A0A8C0TNV8, A0A8P0NG06
      Conserved Domains (5) summary
      cd00033
      Location:303 → 361
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00020
      Location:443 → 682
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:24 → 135
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00431
      Location:181 → 293
      CUB; CUB domain
      pfam14670
      Location:149 → 177
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. XM_005637210.4 → XP_005637267.1  complement C1s subcomponent

      See identical proteins and their annotated locations for XP_005637267.1

      UniProtKB/TrEMBL
      A0A8C0JQU2, A0A8C0TNV8, A0A8P0NG06
      Conserved Domains (5) summary
      cd00033
      Location:303 → 361
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00020
      Location:443 → 682
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:24 → 135
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00431
      Location:181 → 293
      CUB; CUB domain
      pfam14670
      Location:149 → 177
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    Nucleotide Protein
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