PDCD1 programmed cell death 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: PDCD1provided by VGNC
Official Full Name: programmed cell death 1provided by VGNC
Primary source: VGNC:VGNC:44334
See related: Ensembl:ENSCAFG00845024308
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: PD-1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	25	NC_051829.1 (51809256..51820132, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	25	NC_006607.4 (51830362..51840346, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	25	NC_049246.1 (51676302..51686322, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	25	NC_049285.1 (51659966..51669894, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	25	NC_049766.1 (51399146..51409148, complement)

Chromosome 25 - NC_051829.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PD-1 regulates leishmanicidal activity and IL-17 in dogs with leishmaniasis.
Title: PD-1 regulates leishmanicidal activity and IL-17 in dogs with leishmaniasis.
in canine visceral leishmaniasis, PD-1 and its ligands are involved in the induction of T lymphocyte apoptosis and in regulating the production of nitric oxide, TNF-alpha, and IL-4, as well as the parasitic load.
Title: PD-1 function in apoptosis of T lymphocytes in canine visceral leishmaniasis.
PD-1 was highly expressed on tumor-infiltrating lymphocytes obtained from oral melanoma, showing that lymphocytes in this cancer type might have been functionally exhausted.
Title: Immunohistochemical Analysis of PD-L1 Expression in Canine Malignant Cancers and PD-1 Expression on Lymphocytes in Canine Oral Melanoma.
Data indicate that programmed cell death-ligand 1 (PD-L1) was found in the cells of most tumor cell lines, but programmed cell death-1 (PD-1) was not detected in all of the cell lines, only in two mast cell tumor and two lymphoma cell lines.
Title: Programmed Cell Death Ligand 1 Expression in Canine Cancer.
this study demonstrates for the first time that pan-T cell, PD-1-mediated, exhaustion during visceral leishmaniasis influenced macrophage-reactive oxygen intermediate production.
Title: Programmed death 1-mediated T cell exhaustion during visceral leishmaniasis impairs phagocyte function.

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General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in negative regulation of immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of T cell apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: programmed cell death protein 1

Names: programmed death 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001314097.1 → NP_001301026.1 programmed cell death protein 1 precursor

Status: PROVISIONAL

Source sequence(s)

AB850882

UniProtKB/TrEMBL

A0A090BAM7, A0A8C0LM85

Conserved Domains (2) summary

smart00410
Location:39 → 144

IG_like; Immunoglobulin like

pfam07686
Location:38 → 145

V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051829.1 Reference ROS_Cfam_1.0

Range

51809256..51820132 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038434570.1 → XP_038290498.1 programmed cell death protein 1 isoform X1

UniProtKB/TrEMBL

A0A8C0LM85

Related

ENSCAFP00845033639.1, ENSCAFT00845042917.1

Conserved Domains (1) summary

cd16088
Location:34 → 145

IgV_PD1; Immunoglobulin (Ig)-like domain of Programmed Cell Death 1 (PD1)