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    ABCC8 ATP binding cassette subfamily C member 8 [ Canis lupus familiaris (dog) ]

    Gene ID: 485402, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ABCC8provided by VGNC
    Official Full Name
    ATP binding cassette subfamily C member 8provided by VGNC
    Primary source
    VGNC:VGNC:37443
    See related
    Ensembl:ENSCAFG00845014269
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See ABCC8 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 21 NC_051825.1 (41066585..41142504, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 21 NC_006603.4 (39461452..39537172, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 21 NC_049242.1 (40625433..40701220, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 21 NC_049281.1 (40079280..40154977, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 21 NC_049762.1 (40286724..40362392, complement)

    Chromosome 21 - NC_051825.1Genomic Context describing neighboring genes Neighboring gene 28S ribosomal protein S18c, mitochondrial-like Neighboring gene natural killer cell cytotoxicity receptor 3 ligand 1 Neighboring gene uncharacterized LOC119865023 Neighboring gene uncharacterized LOC119865022 Neighboring gene uncharacterized LOC119865021 Neighboring gene potassium inwardly rectifying channel subfamily J member 11 Neighboring gene USH1 protein network component harmonin Neighboring gene otogelin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sulfonylurea receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATP-binding cassette sub-family C member 8
    Names
    ATP-binding cassette, sub-family C (CFTR/MRP), member 8
    sulfonylurea receptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051825.1 Reference ROS_Cfam_1.0

      Range
      41066585..41142504 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038430630.1 → XP_038286558.1  ATP-binding cassette sub-family C member 8 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KVS3
      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1584
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    2. XM_038430632.1 → XP_038286560.1  ATP-binding cassette sub-family C member 8 isoform X3

      UniProtKB/TrEMBL
      A0A8C0KVS3
      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1583
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    3. XM_038430636.1 → XP_038286564.1  ATP-binding cassette sub-family C member 8 isoform X7

      UniProtKB/TrEMBL
      A0A8C0RT37, A0A8I3S0T4
      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1576
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    4. XM_038430635.1 → XP_038286563.1  ATP-binding cassette sub-family C member 8 isoform X6

      UniProtKB/TrEMBL
      A0A8C0RT37, A0A8I3S0T4
      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1577
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    5. XM_038430634.1 → XP_038286562.1  ATP-binding cassette sub-family C member 8 isoform X5

      UniProtKB/TrEMBL
      A0A8C0RT37, A0A8I3S0T4
      Related
      ENSCAFP00845020216.1, ENSCAFT00845025655.1
      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1577
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    6. XM_038430631.1 → XP_038286559.1  ATP-binding cassette sub-family C member 8 isoform X2

      UniProtKB/TrEMBL
      A0A8C0KVS3
      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1583
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    7. XM_038430633.1 → XP_038286561.1  ATP-binding cassette sub-family C member 8 isoform X4

      UniProtKB/TrEMBL
      A0A8C0RT37, A0A8I3S0T4
      Related
      ENSCAFP00845020160.1, ENSCAFT00845025594.1
      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1578
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049281.1 Alternate UMICH_Zoey_3.1

      Range
      40079280..40154977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038505956.1 → XP_038361884.1  ATP-binding cassette sub-family C member 8 isoform X1

      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1584
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    2. XM_038505958.1 → XP_038361886.1  ATP-binding cassette sub-family C member 8 isoform X3

      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1583
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    3. XM_038505962.1 → XP_038361890.1  ATP-binding cassette sub-family C member 8 isoform X7

      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1576
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    4. XM_038505961.1 → XP_038361889.1  ATP-binding cassette sub-family C member 8 isoform X6

      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1577
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    5. XM_038505960.1 → XP_038361888.1  ATP-binding cassette sub-family C member 8 isoform X5

      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1577
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    6. XM_038505957.1 → XP_038361885.1  ATP-binding cassette sub-family C member 8 isoform X2

      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1583
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    7. XM_038505959.1 → XP_038361887.1  ATP-binding cassette sub-family C member 8 isoform X4

      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1578
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049762.1 Alternate UNSW_CanFamBas_1.0

      Range
      40286724..40362392 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038633369.1 → XP_038489297.1  ATP-binding cassette sub-family C member 8 isoform X1

      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1584
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    2. XM_038633371.1 → XP_038489299.1  ATP-binding cassette sub-family C member 8 isoform X3

      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1583
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    3. XM_038633375.1 → XP_038489303.1  ATP-binding cassette sub-family C member 8 isoform X7

      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1576
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    4. XM_038633374.1 → XP_038489302.1  ATP-binding cassette sub-family C member 8 isoform X6

      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1577
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    5. XM_038633373.1 → XP_038489301.1  ATP-binding cassette sub-family C member 8 isoform X5

      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1577
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    6. XM_038633370.1 → XP_038489298.1  ATP-binding cassette sub-family C member 8 isoform X2

      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1583
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    7. XM_038633372.1 → XP_038489300.1  ATP-binding cassette sub-family C member 8 isoform X4

      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1578
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049242.1 Alternate UU_Cfam_GSD_1.0

      Range
      40625433..40701220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038569178.1 → XP_038425106.1  ATP-binding cassette sub-family C member 8 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KVS3
      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1584
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    2. XM_038569180.1 → XP_038425108.1  ATP-binding cassette sub-family C member 8 isoform X3

      UniProtKB/TrEMBL
      A0A8C0KVS3
      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1583
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    3. XM_038569184.1 → XP_038425112.1  ATP-binding cassette sub-family C member 8 isoform X7

      UniProtKB/TrEMBL
      A0A8C0RT37, A0A8I3S0T4
      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1576
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    4. XM_038569183.1 → XP_038425111.1  ATP-binding cassette sub-family C member 8 isoform X6

      UniProtKB/TrEMBL
      A0A8C0RT37, A0A8I3S0T4
      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1577
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    5. XM_038569182.1 → XP_038425110.1  ATP-binding cassette sub-family C member 8 isoform X5

      UniProtKB/TrEMBL
      A0A8C0RT37, A0A8I3S0T4
      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1577
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    6. XM_038569179.1 → XP_038425107.1  ATP-binding cassette sub-family C member 8 isoform X2

      UniProtKB/TrEMBL
      A0A8C0KVS3
      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1583
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    7. XM_038569181.1 → XP_038425109.1  ATP-binding cassette sub-family C member 8 isoform X4

      UniProtKB/TrEMBL
      A0A8C0RT37, A0A8I3S0T4
      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1578
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006603.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      39461452..39537172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038456394.1 → XP_038312322.1  ATP-binding cassette sub-family C member 8 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KVS3
      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1584
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    2. XM_038456396.1 → XP_038312324.1  ATP-binding cassette sub-family C member 8 isoform X3

      UniProtKB/TrEMBL
      A0A8C0KVS3
      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1583
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    3. XM_038456400.1 → XP_038312328.1  ATP-binding cassette sub-family C member 8 isoform X7

      UniProtKB/TrEMBL
      A0A8C0RT37, A0A8I3S0T4
      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1576
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    4. XM_038456399.1 → XP_038312327.1  ATP-binding cassette sub-family C member 8 isoform X6

      UniProtKB/TrEMBL
      A0A8C0RT37, A0A8I3S0T4
      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1577
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    5. XM_038456398.1 → XP_038312326.1  ATP-binding cassette sub-family C member 8 isoform X5

      UniProtKB/TrEMBL
      A0A8C0RT37, A0A8I3S0T4
      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1577
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    6. XM_038456395.1 → XP_038312323.1  ATP-binding cassette sub-family C member 8 isoform X2

      UniProtKB/TrEMBL
      A0A8C0KVS3
      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1583
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    7. XM_038456397.1 → XP_038312325.1  ATP-binding cassette sub-family C member 8 isoform X4

      UniProtKB/TrEMBL
      A0A8C0RT37, A0A8I3S0T4
      Conserved Domains (1) summary
      TIGR00957
      Location:224 → 1578
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    Nucleotide Protein
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