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    SYK spleen associated tyrosine kinase [ Canis lupus familiaris (dog) ]

    Gene ID: 484196, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SYKprovided by VGNC
    Official Full Name
    spleen associated tyrosine kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:47021
    See related
    Ensembl:ENSCAFG00845018106
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See SYK in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (96507029..96590534, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (96356719..96440184, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (96615264..96698710, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (96134620..96217990, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (95855025..95938496, complement)

    Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119869699 Neighboring gene uncharacterized LOC119869704 Neighboring gene uncharacterized LOC106559506 Neighboring gene uncharacterized LOC111097044 Neighboring gene DIRAS family GTPase 2 Neighboring gene uncharacterized LOC111097047

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ZAP-70 and Syk expression in canine lymphoid cells and preliminary results on leukaemia cases. Mortarino M, et al. Vet Immunol Immunopathol, 2009 Apr 15. PMID 19144411
    2. Comparative radiation hybrid map of canine chromosome 1 incorporating SNP and indel polymorphisms. Housley DJ, et al. Genomics, 2004 Aug. PMID 15233990
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in macrophage activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neutrophil activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of alpha-beta T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of mast cell degranulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of platelet aggregation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extrinsic component of cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase SYK
    XP_038322533.1
    XP_038322534.1
    XP_038322535.1
    XP_038322536.1
    XP_038383232.1
    XP_038383233.1
    XP_038383234.1
    XP_038383235.1
    XP_038447537.1
    XP_038447538.1
    XP_038447539.1
    XP_038447540.1
    XP_038460677.1
    XP_038460760.1
    XP_038460843.1
    XP_038460932.1
    XP_038511337.1
    XP_038511338.1
    XP_038511339.1
    XP_038511340.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051805.1 Reference ROS_Cfam_1.0

      Range
      96507029..96590534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038655411.1 → XP_038511339.1  tyrosine-protein kinase SYK isoform X1

      UniProtKB/TrEMBL
      A0A8C0K1S5, A0A8I3P042, A0A8I3P3G0, A0A8P0SQ12, A0A8P0T739
      Related
      ENSCAFP00845025386.1, ENSCAFT00845032468.1
      Conserved Domains (3) summary
      cd05116
      Location:374 → 629
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12 → 115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163 → 261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    2. XM_038655412.1 → XP_038511340.1  tyrosine-protein kinase SYK isoform X2

      UniProtKB/TrEMBL
      A0A8C0K179, A0A8I3PAZ0, A0A8P0N5A1
      Related
      ENSCAFP00845025321.1, ENSCAFT00845032390.1
      Conserved Domains (3) summary
      cd05116
      Location:351 → 606
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12 → 115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163 → 261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    3. XM_038655410.1 → XP_038511338.1  tyrosine-protein kinase SYK isoform X1

      UniProtKB/TrEMBL
      A0A8C0K1S5, A0A8I3P042, A0A8I3P3G0, A0A8P0SQ12, A0A8P0T739
      Conserved Domains (3) summary
      cd05116
      Location:374 → 629
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12 → 115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163 → 261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    4. XM_038655409.1 → XP_038511337.1  tyrosine-protein kinase SYK isoform X1

      UniProtKB/TrEMBL
      A0A8C0K1S5, A0A8I3P042, A0A8I3P3G0, A0A8P0SQ12, A0A8P0T739
      Related
      ENSCAFP00845025066.1, ENSCAFT00845032058.1
      Conserved Domains (3) summary
      cd05116
      Location:374 → 629
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12 → 115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163 → 261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049261.1 Alternate UMICH_Zoey_3.1

      Range
      96134620..96217990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038466607.1 → XP_038322535.1  tyrosine-protein kinase SYK isoform X1

      Conserved Domains (3) summary
      cd05116
      Location:374 → 629
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12 → 115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163 → 261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    2. XM_038466608.1 → XP_038322536.1  tyrosine-protein kinase SYK isoform X2

      Conserved Domains (3) summary
      cd05116
      Location:351 → 606
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12 → 115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163 → 261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    3. XM_038466606.1 → XP_038322534.1  tyrosine-protein kinase SYK isoform X1

      Conserved Domains (3) summary
      cd05116
      Location:374 → 629
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12 → 115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163 → 261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    4. XM_038466605.1 → XP_038322533.1  tyrosine-protein kinase SYK isoform X1

      Conserved Domains (3) summary
      cd05116
      Location:374 → 629
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12 → 115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163 → 261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

      Range
      95855025..95938496 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038591611.1 → XP_038447539.1  tyrosine-protein kinase SYK isoform X1

      Conserved Domains (3) summary
      cd05116
      Location:374 → 629
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12 → 115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163 → 261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    2. XM_038591612.1 → XP_038447540.1  tyrosine-protein kinase SYK isoform X2

      Conserved Domains (3) summary
      cd05116
      Location:351 → 606
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12 → 115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163 → 261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    3. XM_038591610.1 → XP_038447538.1  tyrosine-protein kinase SYK isoform X1

      Conserved Domains (3) summary
      cd05116
      Location:374 → 629
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12 → 115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163 → 261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    4. XM_038591609.1 → XP_038447537.1  tyrosine-protein kinase SYK isoform X1

      Conserved Domains (3) summary
      cd05116
      Location:374 → 629
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12 → 115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163 → 261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

      Range
      96615264..96698710 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038527306.1 → XP_038383234.1  tyrosine-protein kinase SYK isoform X1

      UniProtKB/TrEMBL
      A0A8C0K1S5, A0A8I3P042, A0A8I3P3G0, A0A8P0SQ12, A0A8P0T739
      Conserved Domains (3) summary
      cd05116
      Location:374 → 629
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12 → 115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163 → 261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    2. XM_038527307.1 → XP_038383235.1  tyrosine-protein kinase SYK isoform X2

      UniProtKB/TrEMBL
      A0A8C0K179, A0A8I3PAZ0, A0A8P0N5A1
      Conserved Domains (3) summary
      cd05116
      Location:351 → 606
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12 → 115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163 → 261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    3. XM_038527305.1 → XP_038383233.1  tyrosine-protein kinase SYK isoform X1

      UniProtKB/TrEMBL
      A0A8C0K1S5, A0A8I3P042, A0A8I3P3G0, A0A8P0SQ12, A0A8P0T739
      Conserved Domains (3) summary
      cd05116
      Location:374 → 629
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12 → 115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163 → 261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    4. XM_038527304.1 → XP_038383232.1  tyrosine-protein kinase SYK isoform X1

      UniProtKB/TrEMBL
      A0A8C0K1S5, A0A8I3P042, A0A8I3P3G0, A0A8P0SQ12, A0A8P0T739
      Conserved Domains (3) summary
      cd05116
      Location:374 → 629
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12 → 115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163 → 261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      96356719..96440184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038604915.1 → XP_038460843.1  tyrosine-protein kinase SYK isoform X1

      UniProtKB/TrEMBL
      A0A8C0K1S5, A0A8I3P042, A0A8I3P3G0, A0A8P0SQ12, A0A8P0T739
      Conserved Domains (3) summary
      cd05116
      Location:374 → 629
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12 → 115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163 → 261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    2. XM_038605004.1 → XP_038460932.1  tyrosine-protein kinase SYK isoform X2

      UniProtKB/TrEMBL
      A0A8C0K179, A0A8I3PAZ0, A0A8P0N5A1
      Conserved Domains (3) summary
      cd05116
      Location:351 → 606
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12 → 115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163 → 261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    3. XM_038604832.1 → XP_038460760.1  tyrosine-protein kinase SYK isoform X1

      UniProtKB/TrEMBL
      A0A8C0K1S5, A0A8I3P042, A0A8I3P3G0, A0A8P0SQ12, A0A8P0T739
      Conserved Domains (3) summary
      cd05116
      Location:374 → 629
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12 → 115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163 → 261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    4. XM_038604749.1 → XP_038460677.1  tyrosine-protein kinase SYK isoform X1

      UniProtKB/TrEMBL
      A0A8C0K1S5, A0A8I3P042, A0A8I3P3G0, A0A8P0SQ12, A0A8P0T739
      Conserved Domains (3) summary
      cd05116
      Location:374 → 629
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12 → 115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163 → 261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
    Nucleotide Protein
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