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    KCNQ1 potassium voltage-gated channel subfamily Q member 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 483669, updated on 17-Aug-2024

    Summary

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    Official Symbol
    KCNQ1provided by VGNC
    Official Full Name
    potassium voltage-gated channel subfamily Q member 1provided by VGNC
    Primary source
    VGNC:VGNC:51877
    See related
    Ensembl:ENSCAFG00845011629
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See KCNQ1 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 18 NC_051822.1 (47186461..47510762)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 18 NC_006600.4 (45116523..45440309)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 18 NC_049239.1 (46962029..47285048)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 18 NC_049278.1 (46634218..46955821)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 18 NC_049759.1 (46214974..46538652)

    Chromosome 18 - NC_051822.1Genomic Context describing neighboring genes Neighboring gene tumor suppressing subtransferable candidate 4 Neighboring gene transient receptor potential cation channel subfamily M member 5 Neighboring gene uncharacterized LOC119864243 Neighboring gene microRNA mir-8859a Neighboring gene microRNA mir-8859b Neighboring gene uncharacterized LOC119864236 Neighboring gene cyclin dependent kinase inhibitor 1C Neighboring gene solute carrier family 22 member 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sudden death associated with QT interval prolongation and KCNQ1 gene mutation in a family of English Springer Spaniels. Ware WA, et al. J Vet Intern Med, 2015 Mar-Apr. PMID 25779927, Free PMC Article
    2. Modulation of KCNQ1 alternative splicing regulates cardiac IKs and action potential repolarization. Lee HC, et al. Heart Rhythm, 2013 Aug. PMID 23608591, Free PMC Article
    3. Feedback remodeling of cardiac potassium current expression: a novel potential mechanism for control of repolarization reserve. Xiao L, et al. Circulation, 2008 Sep 2. PMID 18711016
    4. A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein. Andersen MN, et al. J Biol Chem, 2013 Dec 27. PMID 24214981, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An inherited long QT syndrome, associated with a mutation of KCNQ1, is reported in a family of dogs.
      Title: Sudden death associated with QT interval prolongation and KCNQ1 gene mutation in a family of English Springer Spaniels.
    2. Amiloride regulates slow delayed-rectifier potassium current and action potentials with transmural differences and reduces arrhythmogenicity through the modulation of KCNQ1 splicing.
      Title: Modulation of KCNQ1 alternative splicing regulates cardiac IKs and action potential repolarization.
    3. PI3K-SGK1 pathway stabilizes Kv7.1 surface expression by inhibiting Nedd4-2-dependent endocytosis and thereby demonstrates that Nedd4-2 is a key regulator of Kv7.1 localization and turnover in epithelial cells.
      Title: A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    potassium voltage-gated channel subfamily KQT member 1; LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily KQT member 1
    Names
    mutant potassium voltage-gated channel KQT-like subfamily member 1
    potassium voltage-gated channel, KQT-like subfamily, member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051822.1 Reference ROS_Cfam_1.0

      Range
      47186461..47510762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038424639.1 → XP_038280567.1  potassium voltage-gated channel subfamily KQT member 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0QAC9
      Conserved Domains (2) summary
      pfam00520
      Location:121 → 357
      Ion_trans; Ion transport protein
      pfam03520
      Location:510 → 584
      KCNQ_channel; KCNQ voltage-gated potassium channel

    2. XM_038424640.1 → XP_038280568.1  potassium voltage-gated channel subfamily KQT member 1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0QAC9, A0A8C0RTZ1, A0A8I3N918
      Related
      ENSCAFP00845016303.1, ENSCAFT00845020781.1
      Conserved Domains (2) summary
      pfam00520
      Location:121 → 357
      Ion_trans; Ion transport protein
      pfam03520
      Location:510 → 616
      KCNQ_channel; KCNQ voltage-gated potassium channel

    3. XM_038424641.1 → XP_038280569.1  potassium voltage-gated channel subfamily KQT member 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I3NJY6, A0A8P0NT79
      Conserved Domains (2) summary
      pfam00520
      Location:18 → 217
      Ion_trans; Ion transport protein
      pfam03520
      Location:370 → 444
      KCNQ_channel; KCNQ voltage-gated potassium channel

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049278.1 Alternate UMICH_Zoey_3.1

      Range
      46634218..46955821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038500923.1 → XP_038356851.1  LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily KQT member 1 isoform X3

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049759.1 Alternate UNSW_CanFamBas_1.0

      Range
      46214974..46538652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038627710.1 → XP_038483638.1  potassium voltage-gated channel subfamily KQT member 1 isoform X3

      Conserved Domains (2) summary
      pfam00520
      Location:121 → 357
      Ion_trans; Ion transport protein
      pfam03520
      Location:510 → 616
      KCNQ_channel; KCNQ voltage-gated potassium channel

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049239.1 Alternate UU_Cfam_GSD_1.0

      Range
      46962029..47285048
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038563590.1 → XP_038419518.1  potassium voltage-gated channel subfamily KQT member 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0PU64, A0A8C0QAC9

    2. XM_038563591.1 → XP_038419519.1  potassium voltage-gated channel subfamily KQT member 1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0QAC9, A0A8C0RTZ1, A0A8I3N918
      Conserved Domains (2) summary
      pfam00520
      Location:121 → 357
      Ion_trans; Ion transport protein
      pfam03520
      Location:510 → 616
      KCNQ_channel; KCNQ voltage-gated potassium channel

    3. XM_038563592.1 → XP_038419520.1  potassium voltage-gated channel subfamily KQT member 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I3NJY6, A0A8P0NT79

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      45116523..45440309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038454414.1 → XP_038310342.1  potassium voltage-gated channel subfamily KQT member 1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0QAC9, A0A8C0RTZ1, A0A8I3N918
      Conserved Domains (2) summary
      pfam00520
      Location:121 → 357
      Ion_trans; Ion transport protein
      pfam03520
      Location:510 → 616
      KCNQ_channel; KCNQ voltage-gated potassium channel
    Nucleotide Protein
    Heading Accession and Version

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