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    CNTF ciliary neurotrophic factor [ Canis lupus familiaris (dog) ]

    Gene ID: 483464, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CNTFprovided by VGNC
    Official Full Name
    ciliary neurotrophic factorprovided by VGNC
    Primary source
    VGNC:VGNC:39429
    See related
    Ensembl:ENSCAFG00845018289
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See CNTF in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 18 NC_051822.1 (38411043..38418605, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 18 NC_006600.4 (37294972..37302526, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 18 NC_049239.1 (38203356..38210926, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 18 NC_049278.1 (38010392..38017942, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 18 NC_049759.1 (37581125..37588678, complement)

    Chromosome 18 - NC_051822.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111090956 Neighboring gene glycine-N-acyltransferase Neighboring gene protein SET-like Neighboring gene ZFP91 zinc finger protein, atypical E3 ubiquitin ligase Neighboring gene uncharacterized LOC119864222 Neighboring gene leupaxin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ciliary neurotrophic factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in astrocyte activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ciliary neurotrophic factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of axon regeneration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of tyrosine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ciliary neurotrophic factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051822.1 Reference ROS_Cfam_1.0

      Range
      38411043..38418605 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038424262.1 → XP_038280190.1  ciliary neurotrophic factor

      UniProtKB/TrEMBL
      A0A8I3NW42
      Conserved Domains (1) summary
      pfam01110
      Location:1 → 186
      CNTF; Ciliary neurotrophic factor

    2. XM_038424261.1 → XP_038280189.1  ciliary neurotrophic factor

      UniProtKB/TrEMBL
      A0A8I3NW42
      Conserved Domains (1) summary
      pfam01110
      Location:1 → 186
      CNTF; Ciliary neurotrophic factor

    3. XM_038424260.1 → XP_038280188.1  ciliary neurotrophic factor

      UniProtKB/TrEMBL
      A0A8I3NW42
      Conserved Domains (1) summary
      pfam01110
      Location:1 → 186
      CNTF; Ciliary neurotrophic factor

    4. XM_038424258.1 → XP_038280186.1  ciliary neurotrophic factor

      UniProtKB/TrEMBL
      A0A8I3NW42
      Related
      ENSCAFP00845025375.1, ENSCAFT00845032455.1
      Conserved Domains (1) summary
      pfam01110
      Location:1 → 186
      CNTF; Ciliary neurotrophic factor

    5. XM_038424259.1 → XP_038280187.1  ciliary neurotrophic factor

      UniProtKB/TrEMBL
      A0A8I3NW42
      Conserved Domains (1) summary
      pfam01110
      Location:1 → 186
      CNTF; Ciliary neurotrophic factor

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049278.1 Alternate UMICH_Zoey_3.1

      Range
      38010392..38017942 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038500615.1 → XP_038356543.1  ciliary neurotrophic factor

    2. XM_038500614.1 → XP_038356542.1  ciliary neurotrophic factor

    3. XM_038500613.1 → XP_038356541.1  ciliary neurotrophic factor

    4. XM_038500611.1 → XP_038356539.1  ciliary neurotrophic factor

    5. XM_038500612.1 → XP_038356540.1  ciliary neurotrophic factor

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049759.1 Alternate UNSW_CanFamBas_1.0

      Range
      37581125..37588678 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038627312.1 → XP_038483240.1  ciliary neurotrophic factor

    2. XM_038627311.1 → XP_038483239.1  ciliary neurotrophic factor

    3. XM_038627310.1 → XP_038483238.1  ciliary neurotrophic factor

    4. XM_038627308.1 → XP_038483236.1  ciliary neurotrophic factor

    5. XM_038627309.1 → XP_038483237.1  ciliary neurotrophic factor

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049239.1 Alternate UU_Cfam_GSD_1.0

      Range
      38203356..38210926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038563195.1 → XP_038419123.1  ciliary neurotrophic factor

      UniProtKB/TrEMBL
      A0A8I3NW42
      Conserved Domains (1) summary
      pfam01110
      Location:1 → 186
      CNTF; Ciliary neurotrophic factor

    2. XM_038563193.1 → XP_038419121.1  ciliary neurotrophic factor

      UniProtKB/TrEMBL
      A0A8I3NW42
      Conserved Domains (1) summary
      pfam01110
      Location:1 → 186
      CNTF; Ciliary neurotrophic factor

    3. XM_038563192.1 → XP_038419120.1  ciliary neurotrophic factor

      UniProtKB/TrEMBL
      A0A8I3NW42
      Conserved Domains (1) summary
      pfam01110
      Location:1 → 186
      CNTF; Ciliary neurotrophic factor

    4. XM_038563190.1 → XP_038419118.1  ciliary neurotrophic factor

      UniProtKB/TrEMBL
      A0A8I3NW42
      Conserved Domains (1) summary
      pfam01110
      Location:1 → 186
      CNTF; Ciliary neurotrophic factor

    5. XM_038563191.1 → XP_038419119.1  ciliary neurotrophic factor

      UniProtKB/TrEMBL
      A0A8I3NW42
      Conserved Domains (1) summary
      pfam01110
      Location:1 → 186
      CNTF; Ciliary neurotrophic factor

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      37294972..37302526 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005631189.2 → XP_005631246.1  ciliary neurotrophic factor

      See identical proteins and their annotated locations for XP_005631246.1

      UniProtKB/TrEMBL
      A0A8C0JJL7, A0A8P0NA50
      Conserved Domains (1) summary
      pfam01110
      Location:1 → 186
      CNTF; Ciliary neurotrophic factor

    2. XM_005631188.3 → XP_005631245.1  ciliary neurotrophic factor

      See identical proteins and their annotated locations for XP_005631245.1

      UniProtKB/TrEMBL
      A0A8C0JJL7, A0A8P0NA50
      Conserved Domains (1) summary
      pfam01110
      Location:1 → 186
      CNTF; Ciliary neurotrophic factor

    3. XM_005631186.3 → XP_005631243.1  ciliary neurotrophic factor

      See identical proteins and their annotated locations for XP_005631243.1

      UniProtKB/TrEMBL
      A0A8C0JJL7, A0A8P0NA50
      Conserved Domains (1) summary
      pfam01110
      Location:1 → 186
      CNTF; Ciliary neurotrophic factor

    4. XM_005631185.3 → XP_005631242.1  ciliary neurotrophic factor

      See identical proteins and their annotated locations for XP_005631242.1

      UniProtKB/TrEMBL
      A0A8C0JJL7, A0A8P0NA50
      Conserved Domains (1) summary
      pfam01110
      Location:1 → 186
      CNTF; Ciliary neurotrophic factor

    5. XM_005631187.3 → XP_005631244.1  ciliary neurotrophic factor

      See identical proteins and their annotated locations for XP_005631244.1

      UniProtKB/TrEMBL
      A0A8C0JJL7, A0A8P0NA50
      Conserved Domains (1) summary
      pfam01110
      Location:1 → 186
      CNTF; Ciliary neurotrophic factor
    Nucleotide Protein
    Heading Accession and Version

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